Linear classifiers and selection of informative features

In this work, to construct classifiers for two linearly inseparable sets, the problem of minimizing the margin of incorrect classification is formulated, approaches to achieving approximate solution, and calculation estimates of the optimal value for this problem, are considered. Results of computational experiments that compare proposed approaches with SVM are presented. The problem of identifying informative features for large-dimensional diagnostic applications is analyzed and algorithms for its solution are developed.     

Improving the reliability of electric drives of exhausters of the oxygen-converter process

This paper deals with increasing the reliability of electric drives of exhausters of the oxygen-converter process. The dependences of the reliability parameters in the electrical converter–electric motor system on the power reserve were obtained. The costs for the installed equipment were taken as an optimization criterion. It is noted that improving the reliability of an electric drive is possible both by increasing the overall power of the power unit and by changing the number of phases. It is shown that the reliability of the system can be improved in a synchronous electric drive with pulse-vector control at the reservation of a semiconductor converter. A mathematical model of the electrical converter–reluctance motor with a field-regulated machine complex is proposed. The results of the mathematical modeling of the synchronous electric drive with pulse-vector control are considered. The dependence of the specific electric parameters on the number of phases is determined.     

Solid-state reorganization,melting and melt-recrystallization of conformationally disordered crystals (α′-phase) of poly (l-lactic acid)

Conformationally disordered α′-crystals of poly (l-lactic acid) were formed by crystallization of the melt at high supercooling at 95 °C. Analysis of their melting temperature as a function of the crystallinity revealed absence of crystal thickening during isothermal crystallization. Annealing of α′-crystals between the crystallization temperature of 95 °C and their zero-entropy production melting temperature of 150 °C leads to their stabilization, mainly by solid-state reorganization. Heating faster than 30 K s⁻¹ suppresses reorganization and permits superheating of the α′-phase. Consequently, isothermal melting followed by melt-recrystallization becomes accessible. Melting is completed within few hundreds of milliseconds, and melt-recrystallization is about two orders of magnitude faster than crystallization of the isotropic melt at identical temperature. The time required for melting decreases with superheating and increases with the lateral dimension of the lamellar crystals. Laterally extended lamellae require long time for melting of the outer crystal layers, which allows stabilization of the central crystal part. These crystal remnants then serve as seed for immediate recrystallization. In case of complete melting of smaller lamellae, melt-recrystallization is retarded but still distinctly faster than cold- and melt-crystallization, due to incomplete isotropization of the melt.     

The Role of Altered Mitochondrial Metabolism in Thyroid Cancer Development and Mitochondria-Targeted Thyroid Cancer Treatment

Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria—primarily, the regulation of mitochondria-mediated apoptosis, Ca²⁺ homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy.     

Modulating mTOR Signaling as a Promising Therapeutic Strategy for Atherosclerosis

For more than a decade, atherosclerosis has been one of the leading causes of death in developed countries. The issue of treatment and prevention of the disease is especially acute. Despite the huge amount of basic and clinical research, a significant number of gaps remain in our understanding of the pathogenesis of atherosclerosis, and only their closure will bring us closer to understanding the causes of the disease at the cellular and molecular levels and, accordingly, to the development of an effective treatment. One of the seemingly well-studied elements of atherogenesis is the mTOR signaling pathway. However, more and more new details are still being clarified. Therapeutic strategies associated with rapamycin have worked well in a number of different diseases, and there is every reason to believe that targeting components of the mTOR pathway may pay off in atherosclerosis as well.     

SHS-produced Co<Superscript>2+</Superscript>Ti<Superscript>4+</Superscript>-doped barium and strontium hexaferrites: Static and dynamic magnetic properties

Static and dynamic magnetic properties of SHS-produced BaFe_12–2x (Co _х Ti _х )O₁₉ (х = 1.0, 1.1, 1.2) and SrFe_12–2y (Co _y Ti _y )O₁₉ (0 ≤ y ≤ 1.0) hexaferrites were characterized by magnetization and FMR measurements. Dynamic properties of SrFe_12–2y (Co _y Ti _y )O₁₉ hexaferrites were rationalized in terms of not only magnetic anisotropy but also the anisotropy of magnetomechanical ratio. SHS-produced ferrites can be recommended for designing radar-absorbent coatings and other SHF devices operating in the range 20–50 GHz.     

Photoelectric characteristics of focal plane arrays based on epitaxial layers of indium antimonide deposited on a heavily doped substrate

Photoelectric characteristics of a 320 × 256-element focal plane array (FPA) with a pitch of 30 μm, whose photosensitive element is formed in the InSb epitaxial layer deposited on a heavily doped substrate, have been investigated. For a relative aperture of 1: 0.94 and an integration time of 1.46 ms, the mean value of the noise-equivalent temperature difference is 10.5 mK, the percentage of defective elements is 0.12%, and the correction time is more than 3 h. The FPA has been compared to similar commercial devices based on bulk InSb.     

Improved iron-ore pellets for blast furnaces

A production technology for iron-ore materials with improved metallurgical characteristics is developed and tested. The following materials are considered: fluxed pellets containing residual carbon; fluxed local agglomerates from concentrates with a wide range of silica content; local agglomerates with an elevated iron content; local agglomerates with residual carbon; and local agglomerates with both elevated iron content and residual carbon.