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11.
Elasser A. Kheraluwala M.H. Ghezzo M. Steigerwald R.L. Evers N.A. Kretchmer J. Chow T.P. 《Industry Applications, IEEE Transactions on》2003,39(4):915-921
Recent progress in silicon carbide (SiC) material has made it feasible to build power devices of reasonable current density. This paper presents results including a comparison with state-of-the-art silicon diodes. Switching losses for two silicon diodes (a fast diode, 600 V, 50 A, 60 ns Trr), an ultrafast silicon diode (600 V, 50 A, 23 ns Trr), and a 4H-SiC diode (600 V, 50 A) are compared. The effect of diode reverse recovery on the turn-on losses of a fast insulated gate bipolar transistor (IGBT) are studied both at room temperature and at 150 /spl deg/C. At room temperature, SiC diodes allow a reduction of IGBT turn-on losses by 25% compared to ultrafast silicon diodes and by 70% compared to fast silicon diodes. At 150 /spl deg/C junction temperature, SiC diodes allow turn-on loss reductions of 35% and 85% compared to ultrafast and fast silicon diodes, respectively. The silicon and SiC diodes are used in a boost converter with the IGBT to assess the overall effect of SiC diodes on the converter characteristics. Efficiency measurements at light load (100 W) and full load (500 W) are reported. Although SiC diodes exhibit very low switching losses, their high conduction losses due to the high forward drop dominate the overall losses, hence reducing the overall efficiency. Since this is an ongoing development, it is expected that future prototypes will have improved forward characteristics. 相似文献
12.
Dr. Remya Rajan Dr. Dirk Schepmann Ruben Steigerwald Dr. Julian A. Schreiber Dr. Ehab El-Awaad Prof. Joachim Jose Prof. Guiscard Seebohm Prof. Bernhard Wünsch 《ChemMedChem》2021,16(20):3201-3209
Recent studies have shown the involvement of GluN2A subunit-containing NMDA receptors in various neurological and pathological disorders. In the X-ray crystal structure, TCN-201 ( 1 ) and analogous pyrazine derivatives 2 and 3 adopt a U-shape (hairpin) conformation within the binding site formed by the ligand binding domains of the GluN1 and GluN2A subunits. In order to mimic the resulting π/π-interactions of two aromatic rings in the binding site, a [2.2]paracyclophane system was designed to lock these aromatic rings in a parallel orientation. Acylation of [2.2]paracyclophane ( 5 ) with oxalyl chloride and chloroacetyl chloride and subsequent transformations led to the oxalamide 7 , triazole 10 and benzamides 12 . The GluN2A inhibitory activities of the paracyclophane derivatives were tested with two-electrode voltage clamp electrophysiology using Xenopus laevis oocytes expressing selectively functional NMDA receptors with GluN2A subunit. The o-iodobenzamide 12 b with the highest similarity to TCN-201 showed the highest GuN2A inhibitory activity of this series of compounds. At a concentration of 10 μM, 12 b reached 36 % of the inhibitory activity of TCN-201 ( 1 ). This result indicates that the [2.2]paracyclophane system is well accepted by the TCN-201 binding site. 相似文献
13.
14.
Architecture and Physical Implementation of a Third Generation 65 nm, 16 Core, 32 Thread Chip-Multithreading SPARC Processor 总被引:1,自引:0,他引:1
Konstadinidis G.K. Tremblay M. Chaudhry S. Rashid M. Lai P.F. Otaguro Y. Orginos Y. Parampalli S. Steigerwald M. Gundala S. Pyapali R. Rarick L.D. Elkin I. Ge Y. Parulkar I. 《Solid-State Circuits, IEEE Journal of》2009,44(1):7-17
This third-generation Chip-Multithreading (CMT) SPARC processor consists of 16 cores with shared memory architecture and supports a total of 32 main threads plus 32 scout threads. It is targeted for high-performance servers, and is optimized for both single- and multi-threaded applications. The 396 mm2 chip is fabricated in an 11 metal layer 65-nm CMOS process and operates at a nominal frequency of 2.3 GHz, consuming a maximum power of 250 W at 1.2 V. This paper provides an overview of the architectural highlights and describes the physical implementation challenges and solutions including circuit innovations in memory arrays, register files, and floating-point hardware that boost the performance and circuit robustness with low area overhead. 相似文献
15.
Illumination with solid state lighting technology 总被引:13,自引:0,他引:13
Steigerwald D.A. Bhat J.C. Collins D. Fletcher R.M. Holcomb M.O. Ludowise M.J. Martin P.S. Rudaz S.L. 《IEEE journal of selected topics in quantum electronics》2002,8(2):310-320
High-power light-emitting diodes (LEDs) have begun to differentiate themselves from their more common cousins the indicator LED. Today these LEDs are designed to generate 10-100 lm per LED with efficiencies that surpass incandescent and halogen bulbs. After a summary of the motivation for the development of the high-power LED and a look at the future markets, we describe the current state of high-power LED technology and the challenges that lay ahead for development of a true "solid state lamp." We demonstrate record performance and reliability for high-power colored and white LEDs and show results from the worlds first 100-plus lumen white LED lamp, the solid state equivalent of Thomas Edison's 20-W incandescent lightbulb approximately one century later 相似文献
16.
The growth-promoting activity of PDGF-BB was studied on the adult osteoclasts in the present study. The PDGF receptor beta was detected on the osteoclast membrane through immunohistochemistry (LSAB method) and immunomicroscopy. The PDGF-BB was exerted on the osteoclasts that adhered to the bone slice at concentrations of 0, 10, 20, 30, and 40 ng/ml. The volume of Howship's lacuna augmented significantly and the number of resorption pits also increased with its dose (p < 0.01). The activity of both total acid phosphatase (ACP) and tartrate-resistant acid phosphatase (TRAP) increased significantly. These results suggest that PDGF-BB promotes adult osteoclastic bone resorption directly through PDGF receptor beta and is believed to play important roles in the bone healing process and reconstruction. 相似文献
17.
MB Mihailovi? DM Avramovi? IB Jovanovi? OJ Pesut DP Mati? VJ Stojanov 《Canadian Metallurgical Quarterly》1998,17(3-4):285-289
Among the 57 monoclonal antibodies analyzed within the T-cell group of the Second International Swine CD Workshop, one mAb fell within cluster T14a that included the CD6 standard a38b2 (No. 175). The new mAb MIL8 (No. 082) and a38b2 both precipitated from activated T-cells a 150 kDa monomeric protein. Staining patterns on the various cell types were similar. There was no inhibition of binding of either mAb to peripheral blood T-cells with the opposite mAb. The new mAb, MIL8, reacts with a separate epitope on porcine wCD6. 相似文献
18.
During the last 10 years, several cases of myocardial infarction associated with anabolic steroid use have been reported. Postulated mechanisms to explain this association have included changes in lipid levels, the fibrinolytic system, and platelet aggregation. Clenbuterol is a beta 2-agonist with anabolic properties that has not been seen previously with myocardial infarction. We report a case of myocardial infarction in an otherwise healthy 26-year-old body-builder who recently used clenbuterol and anabolic steroids. In this case, synergistic effects of the two agents seem likely to have played a role in the infarct. The normal coronary arteriograms before any anticoagulant or thrombolytic therapy strongly suggest coronary spasm as the mechanism of the infarct. 相似文献
19.
VJ Robertson 《Canadian Metallurgical Quarterly》1995,75(3):223-32; discussion 233-6
BACKGROUND AND PURPOSE: Published research contributes to the knowledge base that distinguishes one discipline from another. More research is now published in the physical therapy journals, but concerns with the profession's knowledge base continue. SUBJECTS: The study examined citations from 78 clinical articles published and indexed on three thematic areas in Physical Therapy between 1951 and 1990. METHODS: Unique items and multiple-cited items were identified and counted and their sources ascertained. Linkages among multiple-cited items in each thematic area were identified and described. RESULTS: Most cited items were unique and not from the physical therapy literature. Few linkages were identified among the clinical articles. CONCLUSION AND DISCUSSION: The lack of evidence of cumulation or of coherence among the articles examined and the extent of reliance on non-physical therapy sources suggest that concerns with the knowledge base of the profession are well founded. 相似文献
20.