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P Lipponen S Aaltomaa M Eskelinen M Ala-Opas VM Kosma 《Canadian Metallurgical Quarterly》1998,34(3):237-243
Selective antagonists to the Type 3 serotonin receptor (5HT3) in combination with corticosteroids are now considered the standard of care for the prevention of emesis from moderately to highly emetogenic chemotherapy. Here we address issues of optimal dose, schedule and route of administration of four currently available selectable 5HT3 antagonists. This paper utilizes an evidence based medicine approach to the literature regarding this class of drugs, emphasizing the results large, randomized, controlled trials to make formal recommendations concerning optimal use of this important new class of anti-emetic agents. We conclude that for each drug there is a plateau in therapeutic efficacy at a definable dose level above which further dose escalation does not improve outcome. Furthermore, a single dose is as effective as multiple doses or continuous infusion, and finally, emerging data demonstrate that the oral route is equally efficacious as the intravenous route of administration, even with highly emetogenic chemotherapy. 相似文献
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Trifluoroethanol (TFE) is often used to increase the helicity of peptides to make them usable as models of helices in proteins. We have measured helix propensities for all 20 amino acids in water and two concentrations of trifluoroethanol, 15 and 40% (v/v) using, as a model system, a peptide derived from the sequence of the alpha-helix of ribonuclease T1. There are three main conclusions from our studies. (1) TFE alters electrostatic interactions in the ribonuclease T1 helical peptide such that the dependence of the helical content on pH is lost in 40% TFE. (2) Helix propensities measured in 15% TFE correlate well with propensities measured in water, however, the correlation with propensities measured in 40% TFE is significantly worse. (3) Propensities measured in alanine-based peptides and the ribonuclease T1 peptide in TFE show very poor agreement, revealing that TFE greatly increases the effect of sequence context. 相似文献
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VM Ponomarenko 《Canadian Metallurgical Quarterly》1995,(5-6):12-15
An assessment is submitted of morbidity rates and physical development of children aged under 14, residing in the territories being monitored after the Chernobyl Power Plant accident. A high level of disharmony in physical development of the children examined was recordable, as was an excess in morbidity of both general and separate classes of disease entities among the pediatric population having been victims of the Chernobyl accident, as compared to that in relatively "clean" areas and in Ukraine as a whole. 相似文献
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Pulmonary diseases caused by dust occupy a leading place in occupational morbidity structure. Those diseases inspire much attention due to their high prevalence, especially in ecologically hazardous regions where the workers are under "double exposure". Upper respiratory tract diseases serve as a trigger for all respiratory disorders in workers exposed to dust. Early diagnosis of respiratory disorders includes history, clinical data, X-ray examination and assessment of pulmonary ventilation and together with concurrent cardiovascular diagnosis is necessary for well-justified prophylaxis. 相似文献
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When initiating monotherapy for the treatment of essential hypertension, multiple determinants factor into the decision. The goal of treatment is to lower blood pressure and lessen the likelihood of progression to target organ failure. Physicians frequently prioritize these determinants and make decisions to initiate monotherapy based on the race of an individual. All too often, however, the black/white issue is overstated and given too much consideration. The overall goal of this review is to suggest the appropriate "role" for racial profiling in the initial selection of an antihypertensive agent. 相似文献