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101.
Multiple steady states are known to be possible in many types of chemical reactor due to the non-linear dependence of reaction rate on either temperature or reactant concentration. It is reasoned in this study that multiple steady states can also exist in a gas-solid fluidised bed reactor. The calculations are based on the two-phase theory of fluidisation and on the important assumption that the interstitial phase gas in completely mixed. Both thermal and concentration multiplicites are shown to be possible. 相似文献
102.
Efficiently identifying and quantifying disease- or treatment-related changes in the abundance of proteins is an important area of research for the pharmaceutical industry. Here we describe an automated, label-free method for finding differences in complex mixtures using complete LC-MS data sets, rather than subsets of extracted peaks or features. The method selectively finds statistically significant differences in the intensity of both high-abundance and low-abundance ions, accounting for the variability of measured intensities and the fact that true differences will persist in time. The method was used to compare two complex peptide mixtures with known peptide differences. This controlled experiment allowed us to assess the validity of each difference found and so to analyze the method's sensitivity and specificity. The method detects both presence versus absence and a 2-fold change in peptide concentration near the limit of detection of the instrument used, where chromatographic peaks may not be sufficiently well defined to be detected in individual samples. The method is more sensitive and gives fewer false positives than subtractive methods that ignore signal variability. Differential mass spectrometry combined with targeted MS/MS analysis of only identified differences may save both computation time and human effort compared to shotgun proteomics approaches. 相似文献
103.
Proteomic analysis of complex protein mixtures using proteolytic digestion and liquid chromatography in combination with tandem mass spectrometry is a standard approach in biological studies. Data-dependent acquisition is used to automatically acquire tandem mass spectra of peptides eluting into the mass spectrometer. In more complicated mixtures, for example, whole cell lysates, data-dependent acquisition incompletely samples among the peptide ions present rather than acquiring tandem mass spectra for all ions available. We analyzed the sampling process and developed a statistical model to accurately predict the level of sampling expected for mixtures of a specific complexity. The model also predicts how many analyses are required for saturated sampling of a complex protein mixture. For a yeast-soluble cell lysate 10 analyses are required to reach a 95% saturation level on protein identifications based on our model. The statistical model also suggests a relationship between the level of sampling observed for a protein and the relative abundance of the protein in the mixture. We demonstrate a linear dynamic range over 2 orders of magnitude by using the number of spectra (spectral sampling) acquired for each protein. 相似文献
104.
105.
McGuire R. L. Yates E. C. Crandall D. G. Hatcher C. R. 《IEEE transactions on nuclear science》1965,12(1):24-27
A digital system has been built for making precise measurements of scintillator decay times. The approach used is similar to the one developed by Bollinger and Thomas. Time intervals between the start of a gamma-induced scintillation and the detection of a single light photon are measured with a time-to-height converter and stored in a pulse height analyzer. The apparatus has a time resolution of less than 2 nanoseconds, a dynamic range of greater than four decades, and is able to detect both prompt and slow decay components in plastic and liquid scintillators. For all fast scintillators studied, the decay of light intensity over the first decade is approximately exponential; however, measured decay times are shorter than those generally quoted. Results of measurements made on several commercially available scintillators will be presented, including NE 102, Pilot B, Pilot A, and MEL-150C. 相似文献
106.
AI Necha? VM Sitenko KV Novikov VV Stukalov VT Drobot 《Canadian Metallurgical Quarterly》1980,125(10):27-35
Concrements were found in the ducts of 172 patients subjected to secondary surgical interventions on bile ducts. The detailed analysis of the data failed to answer the question whether the stones could be formed immediately in the ducts without such conditions as a mechanical obstacle for the outflow of bile, the presence of foreign bodies and a big stump of the cystic duct. Such a formation of stones can take place in very few cases. The authors have shown that control cholangiography and especially choledochoscopy can reduce the danger to leave the stones in the ducts, but does not eliminate the danger completely. Nevertheless they think that now it is possible to lessen the indications for biliodigestive anastomoses in choledocholithiasis since the retained stones can be revealed within the first days after surgery and, as a rule, removed with instruments or by other methods using the drainage left in the ducts. 相似文献
107.
108.
Reproducibility of quantitative proteomic analyses of complex biological mixtures by multidimensional protein identification technology 总被引:5,自引:0,他引:5
If quantitative proteomic technologies are to be of widespread use to the biological community, the reproducibility of each method must be investigated and determined. We have analyzed the reproducibility of complex quantitative proteomic analyses of metabolically labeled S. cerevisiae analyzed via multidimensional protein identification technology (MudPIT). Three independent cell growths of S. cerevisiae grown in rich and minimal media and independent MudPIT analyses of each were compared and contrasted. Quantitative MudPIT was found to be intra- and interexperimentally reproducible at both the peptide and protein levels. Proteins of potential low abundance were detected, identified, and quantified by identical peptides from three independent samples. In addition, when multiple peptides were matched to a protein, the relative abundance of each peptide was in agreement across the three samples. Despite the reproducibility, errors in the experimental determination of protein expression levels occurred, but the impact of the variation was minimized by replicate experiments. Last, quantitative MudPIT analyses will likely be improved by increasing the number of peptide hits per protein in a given analysis, which will provide for greater intraexperimental reproducibility. 相似文献
109.
VM Reddy DB McElhinney HA Rajasinghe JR Liddicoat K Hendricks-Munoz JR Fineman FL Hanley 《Canadian Metallurgical Quarterly》1999,117(2):343-351
BACKGROUND: Fetal cardiac bypass causes placental dysfunction, characterized by increased placental vascular resistance, decreased placental blood flow, hypoxia, and acidosis. Vasoactive factors produced by the vascular endothelium, such as nitric oxide and endothelin 1, are important regulators of placental vascular tone and may contribute to this placental dysfunction. METHODS: To investigate the role of the vascular endothelium in placental dysfunction related to fetal cardiac bypass, we studied 3 groups of fetal sheep. In the first group (n = 7) we determined placental hemodynamic responses before and after bypass to an endothelium-dependent vasodilator (acetylcholine), an endothelium-independent vasodilator (nitroprusside), and endothelin 1. In the second group (n = 8) a nonspecific endothelin receptor blocker (PD 145065) was administered and placental hemodynamic values were measured before and after bypass. In the third group (n = 5) endothelin 1 levels were measured before and after bypass. RESULTS: Before fetal cardiac bypass exogenous endothelin 1 decreased placental blood flow by 9% and increased placental resistance by 9%. After bypass endothelin 1 decreased placental flow by 47% and increased resistance by 106%. There was also a significant attenuation of the placental vascular relaxation response to acetylcholine after bypass, whereas the response to nitroprusside was not significantly altered. In fetuses that received the PD 145065, placental vascular resistance increased significantly less than in control fetuses (28% versus 62%). Similarly, placental blood flow decreased significantly more (from 6. 3 +/- 3.1 to 28.3 +/- 10.4 pg/mL; P =.01) in control fetuses than in fetuses receiving PD 145065 (33% versus 20%). Umbilical venous endothelin 1 levels increased significantly in fetuses exposed to fetal bypass but did not change in control fetuses. CONCLUSIONS: The basal endothelial regulatory mechanisms of placental vascular tone were deranged after fetal cardiac bypass. Endothelin receptor blockade, which substantially reduced postbypass placental dysfunction, and other interventions aimed at preserving endothelial function may be effective means of optimizing fetal outcome after cardiac bypass. 相似文献
110.
Zhisheng Chen Derek Yates James K. Neathery Kunlei Liu 《Chemical Engineering Research and Design》2012
Uncaptured fly ash and/or suspended solids from wet flue gas desulfurization (WFGD) scrubbing solutions are one of several factors that will influence the performance and robustness of carbon dioxide capture systems in coal-fired power plants which will be installed prior to the exhaust stack. In this study, a 100 mm ID packed column scrubber was tested with different concentrations of ash in various chemical solutions to evaluate the influence of solids on the fluid dynamics of the packing material. Data reported here are collected from three solutions including water, 30 wt% MEA (monoethanolamine), and 20 wt% potassium carbonate. The packing selected for this study was a 16 mm polypropylene pall rings. Compressed air was used to simulate flue gas at near ambient temperature and pressure. 相似文献