Stepwise synthesis of oligonucleotides. XXII. The synthesis of Tpsi-loop fragments of yeast tRNAIVal and their analogs

The method of the combined use of nucleolytic enzymes was used for the synthesis of Tpsi-loop fragments of yeast valine tRNA and their analogs. Dinucleoside monophosphates, trinucleoside diphosphates and tetranucleoside triphosphates having the sequences of fragments 54-57 and 59-62 or their analogs were synthesized.     

Functional changes after segmental and lobar resections of the lungs at remote periods of observation

Clinico-roentgenological and functional studies were carried out in 78 patients 2--12 years following segmental (42 patients) and lobar (3) pneumonectomies for tuberculosis. An analysis of the data obtained indicated that partial pneumonectomies within the boundaries of 1-5 segments per se fail to produce significant disorders in the ventilatory and gas metabolism function of the lung. 2-12 years after the operation the patients show considerable ventilatory reserves. Significant respiratory disorders are observed only in patients with postoperative complications and pathological changes in the lung, pleura and bronchi conditioned by tuberculosis and non-specific lung pathology.     

Study of the antagonistic action of actinomycetes on anthrax bacilli

Capacity for the growth inhibition of the highly virulent causative agent of Siberia plague was studied with respect to actinomycetous strains from soil samples of the Ukraine. It was found that on nutrient media 88.4, 88.9, 88.1 and 93.4% of the isolates inhibited the growth of Bac. anthracis, Bac. cereus, Bac. mycoides and Tsenkovsky vaccine strain respectively. Representatives of very different taxonomic groups were found among the antagonistic actinomycetes. Clearance of the soil from Siberia plague bacilli stable to the outer effect with the help of the active strain L-721 of Act. chromofuscus was observed. The effect was chown in sterilized soil, not sterile soil and soil monolith.