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61.
NM Nasybullina VP Zherdev VI Gunar VM Kopelevich GS Kozlova 《Canadian Metallurgical Quarterly》1997,60(6):52-54
The authors studied the permeability of the blood-brain barrier (CEB) to two nootropics: calcium ketogomopantothenate (KRA-Ca), a GABA derivative, and and calcium salt of oxybutyrate (OB-Ca), a derivative of GOBA. It was established that both preparations penetrate the CEB easily and are found in the brain at different intervals after their administration. However, essential differences in the distribution constant of these drugs were disclosed: KPA-Ca permeated the CEB more intensively and was accumulated in larger amounts in the late-term intervals. 相似文献
62.
131I dose-dependent thyroid autoimmune disorders in children living around Chernobyl 总被引:1,自引:0,他引:1
EV Vykhovanets VP Chernyshov II Slukvin YG Antipkin AN Vasyuk HF Klimenko KW Strauss 《Canadian Metallurgical Quarterly》1997,84(3):251-259
The nucleotide sequence of 35,400 bp at approximately 10 kb from the right telomere of chromosome VII was determined. The segment contains the MAL1 locus, one of the five unlinked loci sufficient for maltose utilization. Until now, each of these loci was considered to contain three genes (for regulator, permease and alpha-glucosidase), but a fourth gene, presumably an extra alpha-glucosidase gene, was found at MAL1 adjacent to the usual cluster of three genes. The two glucosidase genes are present in opposite orientation, forming an inverted repeat structure. In addition to the four genes at MAL1, there are 11 complete, non-overlapping open reading frames (ORFs) longer than 300 bp in the sequence presented here. A new ABC transporter gene (YGR281w), required for oligomycin resistance was found (YOR1; Katzman et al., 1995), and the previously sequenced BGL2 (YGR282c), ZUO1 (YGR285c) and BIO2 (YGR286c) genes were located. The sequence of BIO2, a biotin synthetase gene, required substantial correction and the size of Bio2p is 375, rather than 356, amino acids. Two ORFs show rather weak similarities to animal genes: YGR278w to an unknown ORF of Caenorhabditis elegans and YGR284c to the murine Surf-4, a member of a cluster of at least four housekeeping genes. The remaining five ORFs do not encode known functions, but three of these show weak to high similarities to other ORFs in the Saccharomyces cerevisiae genome and one (YGR280c) codes for a particularly lysine-rich protein. 相似文献
63.
64.
VA Kholodny? IF Syrbu MM Militsa VP Kovalenko VO Zhulin'sky? OV Kapshytar 《Canadian Metallurgical Quarterly》1997,(11-12):10-11
While examination of 83 patients it was established that in the presence of complicated gastric and duodenal ulcer disease the secondary immune deficiency is developing, which deepens after the surgical intervention conduction. Tiotriazolin, promoting the immune system state and the blood biochemistry indexes normalization, the immune system state and the blood biochemistry indexes stimulation, hemopoiesis stimulation, the treatment results improvement, was applied for immunomodulation. 相似文献
65.
As the data collected in a survey we conducted show, a major part of the modern general practitioner's work continues to be in the field of family medicine. This fact is also confirmed by the results of other surveys of general practice today. Patients still appreciate their GPs as a source of good medical care and counseling for the whole family. Our own study has shown that most patients would even like to see an expansion of the GP's counseling activities. The duration of the doctor-family relationship extends over many years, and is frequently longer than a decade. 相似文献
66.
67.
EI Nikolaeva EA Oteva VP Leutin AB Maslennikov LP Osipova AA Nikolaeva 《Canadian Metallurgical Quarterly》1995,52(3):207-211
In neonates and infants, hearing impairment leads to impaired language and cognitive development. For that reason, early detection of this sensory deficit is of outstanding importance, particularly in pre-term neonates, who constitute a high risk population in regard to very early acquired hearing loss. Evoked (EOAE) and spontaneous otoacoustic emission (SOAE) recording in 93 pre-term and full-term neonates revealed that this technique is potentially useful for auditory screening in neonatology units. EOAEs and SOAEs can be recorded successfully from 30 weeks of conceptional age. SOAEs were found to be prevalent in females and presented higher peak numbers in right than in left ears. Furthermore, SOAE incidence in pre-term and full-term neonates was found to be high in EOAE positive ears, associated with strong and robust EOAEs. 相似文献
68.
OI Potrokhov DV Dolgikh VP Kas'ianovskaia OI Shevchenko 《Canadian Metallurgical Quarterly》1997,(7):14-18
The study covered influence of combined toxic chemicals on fire extinguishers. Acute exposure of respiratory and peripheral nervous systems was demonstrated. Consequences of the exposure were proved to include polyneuropathies, neuroses and other health disorders. 相似文献
69.
Restriction fragment length polymorphism (RFLP) of the apolipoprotein B locus was investigated in the population of Tomsk. The frequencies of alleles and haplotypes of polymorphic restriction sites XbaI, MspI, and EcoRI were determined. The parameters of linkage disequilibrium and polymorphism information content (PIC) were estimated. Comparative data on various regions of the world are shown. 相似文献
70.
The results are given of a numerical modeling of the instrumental functions of integrating encoding systems with multipinhole
encoding collimators for recording ionization radiation. The characteristics of the instrumental functions are investigated
using collimators with pseudorandom and self-supporting pinhole locations, making it possible to compare the tomographic properties
of the collimators and to make an optimal choice.
Translated from Izmeritel'naya Tekhnika, No. 2, pp. 44–50, February, 1997. 相似文献