Kinetics of the reaction of S-carboxymethyl-L-cysteine with palladium(II) chloride

The influence of the acidity and the Cl- concentration on the kinetics of the complex formation between s-carboxymethyl-L-cysteine and Pd(II) chloride was studied with a stopped-flow technique in the pH range from 1.5 to 5.0 at 25 degrees C. The reaction mechanism involving Pd(H2O)4-nCln, LH-, LH2 and LH3+ species was proposed. Fairly good agreement between the computed and experimentally determined rate constants was found.     

Electrophysiologic analysis of efferent projections of the cerebellar fastigial nucleus of cats

Stimulation of ipsilateral gigantocellular reticular and lateral vestibular nuclei of medulla oblongata, pontine lateral and medial nuclei, reticular formation of the midbrain, as well as the ipsi- and contralateral sensomotor cortex induced antidromic ATs recorded intracellularly in Fastigial neurons. Conduction velocity of Fastigial cell axons projecting to various nuclei of the brainstem was 30--35 m/sec and to the cerebral cortex--43--52 m/sec. Organization of the nuclear efferent system is peculiar by the branching of some axons into various structures of the brainstem.     

The effect of taurine on the carbohydrate metabolism of diabetic animals]

A study was made of a new antidiabetic preparation--taurin in various methods of its administration to rats and rabbits with alloxan and ditisone model of diabetes. A short-term restoration of carbohydrate metabolism was seen after intraperitoneal and intravenous injection in a dose of 200 mg/kg. Oral use of aqueous taurin solution in the same dose failed to produce the desirable result. Microcapsulated taurin with acetylcellulose in the capacity of a filler given per os in a dose of 300 mg/kg restored to the normal glycogen content in the liver and leukocytes, blood and urine sugar level, and the insulin-like activity of blood plasma. Taurin (in a concentration of 3 mg/ml) possessed an insulinogenic action in experiments on fragments of the pancreas isolated from diabetia animals.     

Clinical picture, diagnosis and treatment of metastatic melanoma of the brain

The morphological and clinical features of the disease were studied in 73 patients with malanoma metastasis to the brain. A morphological examination revealed predominance of the epithelial-like structure of the tumors over fusocellular, infiltrative growth of metastases in the brain, and many newly formed defective vessels in the metastatic tumors which were conducive to frequent hemorrhages. The clinical picture of the disease was marked by the predominance of general cerebral symptoms over focal. With regard to the diagnosis, much importance is attached to medical history and peculiarities of the clinical manifestations of the disease and to the results of an auxiliary examination (radiocontrast, electrophysiological, etc). Treatment of patients with melanoma metastases in the brain should be combined and should include, whenever indicated, surgical intervention, hormonotherapy, radiotherapy, and chemotherapy.