Clinical picture, diagnosis and treatment of metastatic melanoma of the brain

The morphological and clinical features of the disease were studied in 73 patients with malanoma metastasis to the brain. A morphological examination revealed predominance of the epithelial-like structure of the tumors over fusocellular, infiltrative growth of metastases in the brain, and many newly formed defective vessels in the metastatic tumors which were conducive to frequent hemorrhages. The clinical picture of the disease was marked by the predominance of general cerebral symptoms over focal. With regard to the diagnosis, much importance is attached to medical history and peculiarities of the clinical manifestations of the disease and to the results of an auxiliary examination (radiocontrast, electrophysiological, etc). Treatment of patients with melanoma metastases in the brain should be combined and should include, whenever indicated, surgical intervention, hormonotherapy, radiotherapy, and chemotherapy.     

Ribosomal apparatus of liver cells in the process of carinogenesis induced by 4-dimethylaminoazobenzene

The antigen of hepatitis B was repeatedly examined in 1356 adults patients with acute viral hepatitis. In 701 patients the HBAg was positive at the beginning of illness and in 657 was negative. The maximum of the negative HBAg results could be found in the lower age groups, whereas the maximum of the positive HBAg results was shifted to the 5th and 6th decade. In HBAg positive cases of hepatitis more numerous anicteric and asymptomatic forms could be observed on the other hand, however, at the same time also o more cholestatic forms and subacute necrotizing and malignant forms appeared. The HBAg positive hepatitis had on average also a more serious form and course. From the epidemiological point of view the admission to the hospital, which preceded in 51% of patients appeared as the most important factor. In 16.3% of patients the HBAg postivity persisted still 6 months after the discharge from the hospital.