Dental enamel hypoplasia in children with combined congenital and hereditary defects in the development of the CNS and the locomotor system (infantile cerebral palsy, spinal cord hernias and myopathies)]

The incidence of hypoplasia in children with congenital and hereditary developmental defects of the central nervous system and the locomotor system is high (44.5 +/- 3.5%), much higher than the incidence of hypoplasia in children without neurological disorders (2.0 +/- 2.0%). This is explained by exposure of the fetus and newborn to numerous intensive factors complicating the biological anamnesis because of profound disturbances of the metabolic processes and largely responsible for the underlying neurological disease and defects of hard dental tissues presenting as hypoplasia of the enamel.     

Adsorption of haematoporphyrins on the planar bilayer membrane

Adsorption of haematoporphyrin derivatives with different hydrophobicities of peripheral groups on a planar bilayer lipid membrane (BLM) was studied in the dark and upon illumination by the visible light. Haematoporphyrin molecules were shown to adsorb on the BLM as anions. The adsorption changed the boundary potential at the membrane/water interface, in particular, it altered the potential in the diffuse part of the double layer outside the membrane and increased an additional unscreenable potential drop inside it. Illumination decreased the value of the negative potential drop due probably to the appearance of a positive charge in the haematoporphyrin macrocycle. The adsorption of haematoporphyrins affected the BLM conductivity induced by different ionophores, which can be explained by changes in membrane structure. Haematoporphyrin derivatives with higher hydrophobicities adsorbed deeper inside the membrane, caused greater changes in its structure and displayed a stronger photodynamic effect.     

Mechanism of the radiation-protective effect of indralin

Output from the interpositus nucleus can inhibit the inferior olive, probably via the GABA-ergic nucleo-olivary pathway. It has been suggested that the function of this inhibition might be to regulate synaptic plasticity resulting from parallel fibre/climbing fibre interaction in cerebellar Purkinje cells, by providing negative feedback information to the olive. Thus, when a learned response, generated by the interpositus nucleus, reaches a sufficient amplitude, the olive would be inhibited and further learning blocked. This suggestion was tested in a classical conditioning paradigm. Decerebrate ferrets were trained using electrical skin stimulation of the forelimb as the conditioned stimulus (CS) and periorbital stimulation as the unconditioned stimulus (US). Climbing fibre responses evoked in Purkinje cells by the US were recorded as surface field potentials in the part of the c3 zone controlling eyeblink. It was found that the CS did not inhibit the olive at the beginning of training, but when conditioned responses were large, the olive was inhibited by the CS in some animals. After a number of unpaired CS presentations, which caused extinction of the conditioned response, the inhibition disappeared. The size of individual conditioned responses correlated negatively with the size of the climbing fibre responses evoked by the US. Climbing fibre responses evoked by direct stimulation of the olive were also inhibited. It was concluded that cerebellar output during performance of a conditioned response inhibits the inferior olive. The results thus support the hypothesis of a cerebellar locus of conditioning and are consistent with the proposed role of cerebello-olivary inhibition.     

Possibilities of using surgical laser in the treatment of chronic tonsillitis

A novel technique of surgical treatment of chronic tonsillitis is presented. It implies the use of Ne-YAG laser in contract regimen. Good results were obtained in experiments on the exposure of distal tonsils to intralacunar laser radiation.