Towards a Structured Framework for Techno-Economic Analyses of Chemical Recycling Technologies

The role of chemical recycling (CR) as a valuable complementary strategy to mechanical recycling in closing the carbon cycle for carbon-containing waste is currently being discussed in political, economic, and social spheres. However, CR deployment is hindered by uncertainties regarding its environmental impacts and costs compared to conventional waste treatment and chemical production routes. While methods for assessing CR's environmental impacts are the focus of socio-political debates and investigations, techno-economic analyses (TEA) to evaluate costs of CR remain scarce. To contribute to a standardized framework for assessing the economic viability of CR technologies, this article draws on life cycle assessment and TEA literature to develop a six-stage TEA process for CR. A checklist is also presented to support transparent and comprehensive analyses.     

Electroreduction of organic compounds. 28. Partial Hydrogenation of Polycyclic Aromatic Hydrocarbons by electroreduction in protic solvents

Polycyclic aromatic hydrocarbons ( PAH ) such as anthracene ( 1 ), phenanthrene ( 5 ), acenaphthylene ( 15 ), pyrene ( 17 ), chrysene ( 22 ), and fluoranthene ( 28 ) are selectively hydrogenated upon electroreduction at a lead cathode in ethanolic solution. The degree of hydrogenation and the structure of the products depend on the reaction conditions, in particular on the applied reduction potential.     

Spirooxindol-1,3-oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization

Spirooxindole-1,3-oxazines are a small and structurally unique class of spirooxindole alkaloids. To date, only four of these compounds have been isolated from natural sources, and their biological properties remained unknown thus far. Dioxyreserpine is a synthetic spirooxindole-1,3-oxazine, that can readily be prepared from the Rauvolfia alkaloid (–)-reserpine by catalytic photooxygenation. While dioxyreserpine itself was now identified as a moderately effective antitumoral agent, structurally modified analogs of it emerged as a new class of highly potent and selective growth inhibitors of various human cancers, including pancreatic cancers. Systematic structural optimization ultimately led to an inhibitor displaying low-micromolar IC₅₀-values against six cancer cell lines as well as selective apoptosis induction in vitro.     

Darstellung von Benzo[c]thiophenen nach neueren Varianten der Hinsberg-Reaktion

Preparation of Benzo[c]thiophenes Using a Modified Hinsberg-Reaction Whereas the tetrahydrobenzo[c]thiophenes 3 and 6 are easily obtained from 1 and 2 or 4 their dehydrogenation (i. e. aromatization) is difficult and the yields are low. However, the method allows to prepare hitherto unknown benzo[c]thiophenes with special substituents in the 1,3-positions.