全文获取类型
收费全文 | 1698篇 |
免费 | 21篇 |
国内免费 | 8篇 |
专业分类
电工技术 | 7篇 |
综合类 | 9篇 |
化学工业 | 67篇 |
金属工艺 | 9篇 |
机械仪表 | 7篇 |
建筑科学 | 6篇 |
矿业工程 | 2篇 |
能源动力 | 10篇 |
轻工业 | 31篇 |
水利工程 | 1篇 |
石油天然气 | 4篇 |
武器工业 | 1篇 |
无线电 | 15篇 |
一般工业技术 | 29篇 |
冶金工业 | 1468篇 |
自动化技术 | 61篇 |
出版年
2022年 | 5篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2015年 | 11篇 |
2014年 | 14篇 |
2013年 | 12篇 |
2012年 | 10篇 |
2011年 | 13篇 |
2010年 | 10篇 |
2009年 | 18篇 |
2008年 | 5篇 |
2007年 | 14篇 |
2006年 | 5篇 |
2005年 | 43篇 |
2004年 | 7篇 |
2003年 | 11篇 |
2002年 | 6篇 |
2001年 | 7篇 |
1999年 | 42篇 |
1998年 | 422篇 |
1997年 | 258篇 |
1996年 | 166篇 |
1995年 | 87篇 |
1994年 | 82篇 |
1993年 | 83篇 |
1992年 | 10篇 |
1991年 | 20篇 |
1990年 | 13篇 |
1989年 | 22篇 |
1988年 | 25篇 |
1987年 | 23篇 |
1986年 | 18篇 |
1985年 | 26篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 8篇 |
1981年 | 11篇 |
1980年 | 18篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 40篇 |
1976年 | 100篇 |
1975年 | 9篇 |
1974年 | 3篇 |
1966年 | 2篇 |
1943年 | 2篇 |
1940年 | 2篇 |
排序方式: 共有1727条查询结果,搜索用时 15 毫秒
51.
52.
53.
The role of the blood-brain barrier transporter PTS-1 in regulating concentrations of methionine enkephalin in blood and brain 总被引:1,自引:0,他引:1
The entrainment of the circadian rhythm of locomotor activity was studied in the field mouse Mus booduga in order to examine the relationship between the free-running period (tau) and minimum tolerable light pulse interval of the skeleton photoperiods. The animals were entrained under three different light/dark (LD) schedules, each out of phase with the other. They were then subjected to various skeleton photoperiods created by two repeated light pulses (LPs) interrupting darkness. Animals that selected the shorter interval between the LPs as their "subjective night" had significantly shorter tau (23.13 +/- 0.38 h) as compared to those that selected the longer dark interval as subjective night (tau = 23.87 +/- 0.18 h). When the longer dark interval was 12 h, animals selecting that interval as their subjective night included both long-tau and short-tau individuals. When both intervals of darkness were of equal duration, no difference in the selection of subjective night was seen between short and long-tau animals. When the "dusk" LP for the animals that selected the longer dark interval as subjective night was advanced by 2 h to create a new skeleton photoperiod, the number of transient cycles appearing before steady-state entrainment was found to depend on the duration of the photoperiods. When the night defined by the two LPs was reduced below 6h, a dramatic "phase jump" in the activity rhythm was observed, and the initial phase relationship was restored after a relaxation in the night duration. We observed considerable interindividual variation in the "minimum tolerable light pulse interval of skeleton photoperiods," which we suggest may be due to the observed variation in tau among individuals. 相似文献
54.
The in vitro incorporation of leucine, isoleucine and pyruvate into lipids was compared and the possibility that leucine might
serve as anin situ precursor to the correspondingiso fatty acids in the rat sciatic nerve was studied. The relative incorporation of14C from leucine into lipids vs. nonlipids was 20%, and the incorporation of label into total lipids from leucine was one-half
that from pyruvate. The incorporation of label from leucine and pyruvate into sterols was nearly equivalent, but the incorporation
of label into all other lipid classes from leucine was less than that from pyruvate, and the incorporation of label from isoleucine
into lipids was much less in all cases. No detectable label from leucine was incorporated into brached chain fatty acids.
It is concluded that leucine may be a substantial in vitro precursor to all major lipids in peripheral nerve, especially sterols.
The possibility and significance of a leucine catabolic pathway in the cytosol in relation to availability of 3-hydroxy-3-methylglutaryl
CoA for sterol biosynthesis is discussed. 相似文献
55.
Janna Geith ThomasM. Klaptke Jan Weigand Gerhard Holl 《Propellants, Explosives, Pyrotechnics》2004,29(1):3-8
The enthalpies of combustion (ΔcombH) of dinitrobiuret (DNB) and diaminotetrazolium nitrate (HDAT‐NO3) were determined experimentally using oxygen bomb calorimetry: ΔcombH(DNB)=5195±200 kJ kg−1, ΔcombH(HDAT‐NO3)=7900±300 kJ kg−1. The standard enthalpies of formation (ΔfH°) of DNB and HDAT‐NO3 were obtained on the basis of quantum chemical computations at the electron‐correlated ab initio MP2 (second order Møller‐Plesset perturbation theory) level of theory using a correlation consistent double‐zeta basis set (cc‐pVTZ): ΔfH°(DNB)=−353 kJ mol−1, −1 829 kJ kg−1; ΔfH°(HDAT‐NO3)=+254 kJ mol−1, +1 558 kJ kg−1. The detonation velocities (D) and detonation pressures (P) of DNB and HDAT‐NO3 were calculated using the empirical equations by Kamlet and Jacobs: D(DNB)=8.66 mm μs−1, P(DNB)=33.9 GPa, D(HDAT‐NO3)=8.77 mm μs−1, P(HDAT‐NO3)=33.3 GPa. 相似文献
56.
原油输送中的析蜡问题是影响管道安全运行和管理的重要因素之一。介绍了管壁结蜡影响因素,通过试验,探讨了原油输送温度和管壁温差对管壁蜡沉积速率的影响,得出了输油温度和温差与结蜡层厚度之间的关系,对于预测结蜡规律有一定的参考作用。 相似文献
57.
环氧丙烯酸树脂的合成及其改性 总被引:2,自引:0,他引:2
采用丙烯酸(AA)对环氧树脂(EP)进行光活性改性制备环氧丙烯酸树脂(EA),通过单因素试验法优选出制备EA的最佳反应条件。结果表明:制备EA的最佳反应条件是以N′N-二甲基苯胺为催化剂,w(催化剂)=2.5%(相对于反应物总质量而言);以对苯二酚为阻聚剂,w(阻聚剂)=0.1%(相对于反应物总质量而言);反应温度为90℃,反应时间为2.0~3.5h。当w(引发剂)=1.0%时,EA的固化性能较好。采用多元醇先对EP进行改性,然后再进行光活性改性,可明显降低产物的黏度。 相似文献
58.
Joachim Mittendorf Prof. Dr. Stefan Weigand Dr. Cristina Alonso‐Alija Dr. Erwin Bischoff Dr. Achim Feurer Dr. Michael Gerisch Dr. Armin Kern Dr. Andreas Knorr Dr. Dieter Lang Dr. Klaus Muenter Dr. Martin Radtke Dr. Hartmut Schirok Dr. Karl‐Heinz Schlemmer Dr. Elke Stahl Dr. Alexander Straub Dr. Frank Wunder Dr. Johannes‐Peter Stasch Dr. 《ChemMedChem》2009,4(5):853-865
Direct stimulation of soluble guanylate cyclase (sGC) represents a promising therapeutic strategy for the treatment of a range of diseases, including the severely disabling pulmonary hypertension (PH). Optimization of the unfavorable DMPK profile of previous sGC stimulators provided riociguat, which is currently being investigated in phase III clinical trials for the oral treatment of PH.
59.
60.
Elisabeth M. Haberl Thomas S. Weiss Georg Peschel Kilian Weigand Nikolai Khler Josch K. Pauling Jürgen J. Wenzel Marcus Hring Sabrina Krautbauer Gerhard Liebisch Christa Buechler 《International journal of molecular sciences》2021,22(10)
Hepatocellular carcinoma (HCC) still remains a difficult to cure malignancy. In recent years, the focus has shifted to lipid metabolism for the treatment of HCC. Very little is known about hepatitis B virus (HBV) and C virus (HCV)-related hepatic lipid disturbances in non-malignant and cancer tissues. The present study showed that triacylglycerol and cholesterol concentrations were similar in tumor adjacent HBV and HCV liver, and were not induced in the HCC tissues. Higher levels of free cholesterol, polyunsaturated phospholipids and diacylglycerol species were noted in non-tumorous HBV compared to HCV liver. Moreover, polyunsaturated phospholipids and diacylglycerols, and ceramides declined in tumors of HBV infected patients. All of these lipids remained unchanged in HCV-related HCC. In HCV tumors, polyunsaturated phosphatidylinositol levels were even induced. There were no associations of these lipid classes in non-tumor tissues with hepatic inflammation and fibrosis scores. Moreover, these lipids did not correlate with tumor grade or T-stage in HCC tissues. Lipid reprogramming of the three analysed HBV/HCV related tumors mostly resembled HBV-HCC. Indeed, lipid composition of non-tumorous HCV tissue, HCV tumors, HBV tumors and HBV/HCV tumors was highly similar. The tumor suppressor protein p53 regulates lipid metabolism. The p53 and p53S392 protein levels were induced in the tumors of HBV, HCV and double infected patients, and this was significant in HBV infection. Negative correlation of tumor p53 protein with free cholesterol indicates a role of p53 in cholesterol metabolism. In summary, the current study suggests that therapeutic strategies to target lipid metabolism in chronic viral hepatitis and associated cancers have to consider disease etiology. 相似文献