Steering molecular organization and host-guest interactions using two-dimensional nanoporous coordination systems

Metal-organic coordination networks (MOCNs) have attracted wide interest because they provide a novel route towards porous materials that may find applications in molecular recognition, catalysis, gas storage and separation. The so-called rational design principle-synthesis of materials with predictable structures and properties-has been explored using appropriate organic molecular linkers connecting to metal nodes to control pore size and functionality of open coordination networks. Here we demonstrate the fabrication of surface-supported MOCNs comprising tailored pore sizes and chemical functionality by the modular assembly of polytopic organic carboxylate linker molecules and iron atoms on a Cu(100) surface under ultra-high-vacuum conditions. These arrays provide versatile templates for the handling and organization of functional species at the nanoscale, as is demonstrated by their use to accommodate C(60) guest molecules. Temperature-controlled studies reveal, at the single-molecule level, how pore size and chemical functionality determine the host-guest interactions.     

Induction of apoptosis in human microvascular endothelial cells by divalent cobalt ions. Evidence for integrin-mediated signaling via the cytoskeleton

Wound healing following implantation is characterized by an acute inflammatory reaction and a subsequent reorganizing phase in which angiogenesis is involved. Endothelial cells (EC) participate in both inflammation and angiogenesis. Thus, the effects on functions of EC exerted by implanted materials could affect the progression of wound healing. The corrosion of metallic implants can cause high concentrations of heavy metal ions in the peri-implant tissues. The purpose of the present study was to test the effects of possible corrosion products on the function and viability of human EC in vitro. Long-term exposure of EC to CoCl2 and NiCl2 (3 days, 0.7 mM) leads to a decrease of cell number and changes in cellular morphology. However, the morphological changes between CoCl2- and NiCl2-treated cells differ significantly. The changed morphology of CoCl2-treated EC and the fragmented DNA pattern indicates apoptosis. Nickel-treated cells demonstrated necrosis. The activity of integrins was tested by an assay of cellular adhesion on collagen-coated surfaces. It was shown that the number of adherent cells significantly decreased upon exposure to CoCl2. Our studies suggest that induction of cell death in EC upon exposure to CoCl2 could be attributed to impaired integrin signaling, which leads to a damaged cytoskeleton and culminates in apoptosis.     

Simplified Moment Redistribution of Hybrid HPS 485W Bridge Girders in Negative Bending

Simplified moment redistribution procedures based on shakedown have recently been approved by AASHTO LRFD Bridge Design Specifications (AASHTO 2004). These procedures are currently only applicable for homogeneous girders, and thus, the objective of this study is to evaluate whether these procedures can be further applied for hybrid HPS 485W girders. A parametric study is carried out using validated three-dimensional finite-element (FE) analyses to study the inelastic behavior of hybrid HPS 485W girders in negative bending for this purpose. The effective plastic moments obtained from the FE studies are compared with those from the proposed prediction equations, where good correlation is observed. A design example of a three-span slab-on-girder bridge with hybrid HPS 485W girders using both elastic design and the simplified moment redistribution procedures is also presented, where it is shown that the use of moment redistribution procedures results in a negative bending section that is 13% lighter than the corresponding elastic design.     

CMOS inverters based positive type second generation current conveyor

A new versatile class AB low-voltage second generation current conveyor based on CMOS inverters operating in transconductance mode is presented in this letter. Against traditional design based on CCII+, the circuit is able to operate at low supply voltages and offers numerous advantages like class AB operation, large voltage and current swing, synthesis from digital inverters. Simulation results from a typical 0.35 μm CMOS process had demonstrated the circuit capability to operate at high frequency over wide voltage and wide current swings. The proposed circuit operation has been acted from measurements with the HEF4069UBP from Philips semiconductors [1].     

A geometric approach to remote eye tracking

This paper presents a principled analysis of various combinations of image features to determine their suitability for remote eye tracking. It begins by reviewing the basic theory underlying the connection between eye image and gaze direction. Then a set of approaches is proposed based on different combinations of well-known features and their behaviour is evaluated, taking into account various additional criteria such as free head movement, and minimum hardware and calibration requirements. The paper proposes a final method based on multiple glints and the pupil centre; the method is evaluated experimentally. Future trends in eye tracking technology are also discussed.