Increased Prostaglandin Response to Oxytocin in Ewes Fed a Diet High in Omega-6 Polyunsaturated Fatty Acids

Diets high in omega-6 polyunsaturated fatty acids (n-6) are associated with increased prostaglandin F_2α (PGF_2α) synthesis in cattle, however, the specific effects on the potential prostaglandin response to an oxytocin challenge in sheep have not been reported. The aim of the current study was to determine whether oxytocin-stimulated PGF_2α was significantly increased when ewes were fed a diet high in n-6 compared with a control diet low in n-6. Merino x Border Leicester ewes (n = 30) received one of two dietary treatments, either high in n-6 (70 % oat grain) or low in n-6 (control diet, 100 % cereal/legume silage). Ewes consumed the diets for 44 days prior to two consecutive oxytocin challenges. Plasma n-6 and PGF_2α metabolite (PGFM) concentrations following oxytocin challenge were greater (P < 0.05) when ewes were fed a diet high in n-6 compared with the control diet. A higher availability of n-6 may have lead to an increased in vivo synthesis of PGF_2α, however, further research is required to determine the exact mechanisms involved.     

Cytochrome P450 3A4 activity in premenopausal and postmenopausal women, based on 6-beta-hydroxycortisol:cortisol ratios

STUDY OBJECTIVE: To characterize cytochrome P450 (CYP) 3A4 activity in premenopausal and postmenopausal women by evaluating the urinary 6-beta-hydroxycortisol:cortisol ratio. DESIGN: Prospective study SUBJECTS: Thirteen premenopausal and 13 postmenopausal women who were healthy and not receiving drugs known to affect CYP3A4 activity INTERVENTIONS: Beginning on day 2 of menses, premenopausal women collected first morning urine samples every other day for a complete menstrual cycle. Postmenopausal women collected first morning urine every other day for 28 days. MEASUREMENTS AND MAIN RESULTS: Mean weekly 6-beta-hydroxycortisol:cortisol ratios did not differ during the phase (week) of the menstrual cycle. Daily ratios did not differ in postmenopausal women. No difference between premenopausal and postmenopausal women was found on comparing overall median ratios. CONCLUSION: Cytochrome P450 3A4 activity as measured by 6-beta-hydroxy cortisol:cortisol ratio did not differ by week of menstrual cycle, suggesting no menstrual cycle-related changes. Menopause does not appear to be associated with differences in CYP3A4 activity, compared with premenopause.     

A web-based remote interactive laboratory for Internetworking education

A Web-based remote interactive laboratory (RIL) developed to deliver Internetworking laboratory experience to geographically remote graduate students is presented in this paper. The onsite Internetworking program employs hands-on laboratories in a group setting that correlates with the constructivist and collaborative pedagogical approach. This paper discusses the pedagogical and technical considerations that influence the design and implementation of the remote laboratory environment given the constraints of the special hardware and learning outcomes of the program. For wide-ranging usability, the remote Internetworking (INWK) laboratory uses de facto networking standards and commercial and broad-band Internet connectivity to ensure real-time secure interaction with equipment. A four-tier role architecture consisting of faculty, local facilitators, remote facilitators, and students has been determined appropriate to maintain academic integrity and ensure good quality of interaction with the remote laboratory. A survey employing a five-point scale has been devised to measure the usability of the remote access INWK laboratory.     

Strength of epoxy-resin-based insulation systems in transverse tension and shear using two novel test pieces

A novel test specimen type has been developed to generate engineering data on bonded aluminium surfaces. The test is designed to simulate conditions in a superconducting coil, operating at 4.2 K, in a region where a glass/epoxy composite laminate is loaded primarily in through-thickness tension and in shear. We include the effects of thermal contraction from the cure temperature to the operating temperature of 4.2 K. The test specimen avoids the large stresses associated with the edges of the composite in other through-thickness tension test pieces and results calculated from the measured failure loads of specimens are the peak stresses in the centre of the specimen.     

Probability-Based Chinese Text Processing and Retrieval

We discuss the use of probability-based natural language processing for Chinese text retrieval. We focus on comparing different text extraction methods and probabilistic weighting methods. Several document processing methods and probabilistic weighting functions are presented. A number of experiments have been conducted on large standard text collections. We present the experimental results that compare a word-based text processing method with a character-based method. The experimental results also compare a number of term-weighting functions including both single-unit weighting and compound-unit weighting functions.     

Factors affecting outcome in hypoxic-ischemic encephalopathy in term infants

Forty-nine term infants were prospectively shown to have hypoxic-ischemic encephalopathy (HIE). All infants survived the neonatal period, and all but two infants (seen at 12 months) were followed up to at least 27 months of age. Factors that significantly correlated with outcome included the Sarnat encephalopathy stage and the occurrence of intractable seizures not controlled by phenobarbital sodium alone. There was no association between the one- or five-minute Apgar score, the need for early ventilation, the EEG, the occurrence of seizures, and the subsequent outcome. There was no significant difference in outcome for those infants who received dexamethasone sodium phosphate (n = 29) v those who did not receive the drug (n = 20). A review of 97 term infants with HIE from a regional perinatal program during a one-year period (1979), including 35 of the 49 infants in the present study, did show a significant increase in morbidity and mortality for transported infants.     

Effect of capture on throughput of variable length packet Aloha systems

The effect of the capture phenomenon on the throughput of a radio communications system using the Aloha random access protocol with variable length packets is examined. In a packet radio communications system, the base station typically receives stronger signals from near users than from far users, leading to the so-called ‘near/far effect’. The packet capture phenomenon, in which a packet captures the base station receiver when its signal-to-interface ratio exceeds some threshold, is a consequence of the near/far effect. System throughput with capture is obtained analytically in terms of a tagged packet's conditional capture probability using the most general packet length distribution, i.e. packet length is taken to be exponentially distributed. The maximum throughput and the channel traffic rate corresponding to the maximum throughput of a variable packet Aloha system with capture are both considerably higher than that of a comparable system without capture. Depending on the threshold, the maximum throughput and the channel traffic rate corresponding to maximum throughput of a variable packet Aloha system with capture can be as much as 67% and 120% higher (resp.) than that of a comparable system without capture. Consequently, not only throughput but also the stability of the system is enhanced by the capture effect.     

Structural system identification: from reality to models

The paper is an expository contribution on the subject of structural system identification, measured signal processing and their applications to model-based structural health detection. The materials covered in this paper are by and large extracted from the three theses of the first three authors. The paper focuses on the state-space oriented system identification theory as specialized to structural dynamics governing equations of motion, a judicious use of wavelet transformation techniques for extracting impulse response functions, various input-output combinations for multi-input and multi-output problems, robust ways of identifying both proportional and non-proportional damping parameters, and the use of localized identification theory for damage detection from measured response data. The authors then offer several outstanding challenges in structural system identification theory and their applications.