The use of background and ability profiles to predict college student outcomes.

To determine whether profiles of predictor variables provide incremental prediction of college student outcomes, the authors 1st applied an empirical clustering method to profiles based on the scores of 2,771 entering college students on a battery of biographical data and situational judgment measures, along with SAT and American College Test scores and high school grade point average, which resulted in 5 student groups. Performance of the students in these clusters was meaningfully different on a set of external variables, including college grade point average, self-rated performance, class absenteeism, organizational citizenship behavior, intent to quit their university, and satisfaction with college. The 14 variables in the profile were all significantly correlated with 1 or more of the outcome measures; however, nonlinear prediction of these outcomes on the basis of cluster membership did not add incrementally to a linear-regression-based combination of these 14 variables as predictors. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

EXPLORING FOR FAN AND DELTA SANDSTONES IN THE OFFSHORE FALKLANDS BASINS

Four basins surround the Falkland Islands, but only the North Falkland Basin has been drilled; six wells were drilled there in 1998. Although all six wells encountered good quality sandstones, none of them targeted the basin margins, on what are now thought to be the optimum migration pathways associated with the basin's thick lacustrine source rocks. Subsequently, a 3D seismic survey acquired in 2004 was designed to identify potential basin-margin -derived sandstones entering the basin along transfer zones. From this survey, a number of basin-margin -attached fans have been identified; these prograded into lacustrine waters of varying depths. These Early Cretaceous alluvial/fan delta/deep-lacustrine fan systems are interpreted to provide excellent potential reservoir facies as they are intimately associated with thick, mature source rocks. They will provide the focus for the next planned phase of exploration in the North Falkland Basin.
A phase of drilling is also planned for the basins to the south of the Islands, where large deltaic and fan systems, slightly younger than those imaged in the North Falkland Basin, are seen on seismic to prograde from the same Palaeozoic hinterland that produced the older, North Falkland Basin fans.
This paper attempts to show how sedimentary models derived from targeted seismic programmes following initial exploration can be utilised to plan and improve new drilling campaigns in a frontier basin. It presents an analysis of sediment dispersal patterns in basins of marine and lacustrine origin linked to a single hinterland area, and highlights the nature of the relationship between relay ramp/transfer zone development and sediment dispersal patterns in the subsurface.     

Association of symptoms of depression with diagnostic test charges among older adults

BACKGROUND: Previous studies have documented greater use of health services by depressed persons and have postulated that health care costs could be reduced overall through better recognition and treatment of depression. OBJECTIVE: To determine whether a greater burden of medical illness contributes to excess charges for diagnostic tests among older adults with symptoms of depression. DESIGN: Prospective cohort study. SETTING: A primary care group practice at an academic institution. PATIENTS: 3767 patients 60 years of age and older who completed testing on the Centers for Epidemiologic Studies Depression Scale (CES-D) during routine office visits. MEASUREMENTS: Charges for all inpatient and ambulatory diagnostic testing for 2 years, including clinical pathology, diagnostic imaging, and special procedures; number of visits to the ambulatory care center or emergency department; and number of hospitalizations. The Ambulatory Care Group case-mix approach, which is based on ambulatory diagnoses, was used as a measure of health status and expected resource consumption. RESULTS: Patients with symptoms of depression (CES-D scores > or = 16) were significantly younger (66.6 compared with 68.1 years; P < 0.001), more likely to be white (50.5% compared with 33.9%; P = 0.001), and more likely to be female (75.8% compared with 67.6%; P = 0.001) than were those without these symptoms (CES-D scores < 16). They also had more nonpsychiatric comorbid conditions, had more visits to the ambulatory care center (9.2 compared with 7.8; P < 0.001), were more likely to use the emergency department (52.3% compared with 40%; P = 0.001), were more likely to be hospitalized (22.4% compared with 17%; P = 0.002), and had greater median total diagnostic test charges for a period of 1 year ($583 compared with $387; P < 0.001). The difference in charges, most of which were clinical pathology charges (54.2%), persisted into the second year. Ambulatory Care Group assignment was independently associated with diagnostic test charges. The CES-D summary score was not independently associated with diagnostic test charges when controlling for Ambulatory Care Group assignment. CONCLUSIONS: Patients with symptoms of depression accrue greater average diagnostic test charges. However, these data suggest that such patients also have a greater burden of comorbid nonpsychiatric illness. Efforts to improve outcome and decrease cost for patients who have late-life depression must target interventions to improve the care of psychiatric and medical illness concurrently.     

Effects of soil moisture and water depth on ERS SAR backscatter measurements from an Alaskan wetland complex

We conducted a preliminary investigation of the response of ERS C-band SAR backscatter to variations in soil moisture and surface inundation in wetlands of interior Alaska. Data were collected from 5 wetlands over a three-week period in 2007. Results showed a positive correlation between backscatter and soil moisture in sites dominated by herbaceous vegetation cover (r = 0.74, p < 0.04). ERS SAR backscatter was negatively correlated to water depth in all open (non-forested) wetlands when water table levels were more than 6 cm above the wetland surface (r = − 0.82, p < 0.001). There was no relationship between backscatter and soil moisture in the forested (black spruce-dominated) wetland site. Our preliminary results show that ERS SAR data can be used to monitor variations in hydrologic conditions in high northern latitude wetlands (including peatlands), particularly sites with sparse tree cover.     

Stepwise transplantation of an active site loop between heat-labile enterotoxins LT-II and LT-I and characterization of the obtained hybrid toxins

Members of the cholera toxin family, including Escherichia coli heat-labile enterotoxins LT-I and LT-II, catalyze the covalent modification ofintracellular proteins by transfer of ADP-ribose from NAD to a specificarginine of the target protein. The ADP-ribosylating activity of thesetoxins is located in the A-subunit, for which LT-I and LT-II share a 63%sequence identity. The flexible loop in LT-I, ranging from residue 47 to56, closes over the active site cleft. Previous studies have shown thatpoint mutations in this loop have dramatic effects on the activity of LT-I.Yet, in LT-II the sequence of the equivalent loop differs at four positionsfrom LT-I. Therefore five mutants of the active site loop were created by astepwise replacement of the loop sequence in LT-I with virtually all thecorresponding residues in LT- II. Since we discovered that LT-II had noactivity versus the artificial substratediethylamino-benzylidine-aminoguanidine (DEABAG) while LT-I does, ouractive site mutants most likely probe the NAD binding, not the argininebinding region of the active site. The five hybrid toxins obtained (Q49A,F52N, V53T, Q49V/F52N and Q49V/F52N/V53T) show (i) great differences inholotoxin assembly efficiency; (ii) decreased cytotoxicity in Chinesehamster ovary cells; and (iii) increased in vitro enzymatic activitycompared with wild type LT-I. Specifically, the three mutants containingthe F52N substitution display a greater Vmax for NAD than wild type LT-I.The enzymatic activity of the V53T mutant is significantly higher than thatof wild type LT-I. Apparently this subtle variation at position 53 isbeneficial, in contrast to several other substitutions at position 53 whichpreviously had been shown to be deleterious for activity. The most strikingresult of this study is that the active site loop of LT- I, despite greatsensitivity for point mutations, can essentially be replaced by the activesite loop of LT-II, yielding an active 'hybrid enzyme' as well as 'hybridtoxin'.