Optimization study of the femtosecond laser-induced forward-transfer process with thin aluminum films

The parameters for an effective laser-induced forward-transfer (LIFT) process of aluminum thin films using a femtosecond laser are studied. Deposited feature size as a function of laser fluence, donor film thickness, quality of focus, and the pulse duration are varied, providing a metric of the most desirable conditions for femtosecond LIFT with thin aluminum films.     

Antioxidant mechanism of milk mineral-high-affinity iron binding

ABSTRACT:  Milk mineral (MM), a by-product of whey processing, is an effective antioxidant in meat systems, but the antioxidant mechanism has not been established. MM has been postulated to chelate iron and prevent iron-catalysis of lipid oxidation. The objective of this research was to examine this putative mechanism. MM was compared to sodium tripolyphosphate (STPP), calcium phosphate monobasic (CPM), and calcium pyrophosphate (CPP) to determine iron-binding capacity, sample solubility, and eluate soluble phosphorus after treating samples with a ferrous chloride standard. Scanning electron microscopy with energy-dispersive X-ray analysis was used to localize minerals on iron-treated MM particle surfaces. Histochemical staining for calcium was performed on raw and cooked ground beef samples with added MM. MM bound more iron per gram ( P < 0.05) than the other compounds, and was much less soluble ( P < 0.05) than either STPP or CPM. Mineral localization showed an even distribution of calcium, phosphorus, oxygen, and iron across the MM particle surface, directly demonstrating iron binding to MM particles. Unlike other common chelating agents, such as STPP and citrate, histochemical staining demonstrated that MM remained insoluble in ground beef, even after cooking. The ability of MM to bind iron and remain insoluble may enhance its antioxidant effect by removing iron ions from solution. However, MM particles must be small and well distributed in order to adequately bind iron throughout the food system.     

Orientation variance discrimination in amblyopia

Our previous results showed that while amblyopes can efficiently integrate visual signals, they are poor at segregating signals in noise. This could be either because integration detectors have broader bandwidths or because of a selective extrastriate segregation anomaly. One consequence of the former would be poorer variance discrimination. Using a two-alternative forced-choice paradigm, observers were asked to judge the orientational variance for arrays of 16 Gabors. All observers, be they normal or amblyopic, could perform the task similarly, although at high spatial frequencies, amblyopic eyes needed slightly more incremental variance than the normal eyes. We conclude that normals and amblyopes integrate signals in a similar way.     

Confidence, uncertainty and decision-support relevance in climate predictions

Over the last 20 years, climate models have been developed to an impressive level of complexity. They are core tools in the study of the interactions of many climatic processes and justifiably provide an additional strand in the argument that anthropogenic climate change is a critical global problem. Over a similar period, there has been growing interest in the interpretation and probabilistic analysis of the output of computer models; particularly, models of natural systems. The results of these areas of research are being sought and utilized in the development of policy, in other academic disciplines, and more generally in societal decision making. Here, our focus is solely on complex climate models as predictive tools on decadal and longer time scales. We argue for a reassessment of the role of such models when used for this purpose and a reconsideration of strategies for model development and experimental design. Building on more generic work, we categorize sources of uncertainty as they relate to this specific problem and discuss experimental strategies available for their quantification. Complex climate models, as predictive tools for many variables and scales, cannot be meaningfully calibrated because they are simulating a never before experienced state of the system; the problem is one of extrapolation. It is therefore inappropriate to apply any of the currently available generic techniques which utilize observations to calibrate or weight models to produce forecast probabilities for the real world. To do so is misleading to the users of climate science in wider society. In this context, we discuss where we derive confidence in climate forecasts and present some concepts to aid discussion and communicate the state-of-the-art. Effective communication of the underlying assumptions and sources of forecast uncertainty is critical in the interaction between climate science, the impacts communities and society in general.     

p53 inhibits entry into mitosis when DNA synthesis is blocked

Human and mouse fibroblasts with normal p53 fail to enter mitosis when DNA synthesis is blocked by aphidicolin or hydroxyurea. Isogenic p53-null fibroblasts do enter mitosis with incompletely replicated DNA, revealing that p53 contributes to a checkpoint that ensures that mitosis does not occur until DNA synthesis is complete. When treated with N-(phosphonacetyl)-L-aspartate (PALA), which inhibits pyrimidine nucleotide synthesis, leading to synthesis of damaged DNA from highly unbalanced dNTP pools, p53-null cells enter mitosis after they have completed DNA replication, but cells with wild-type p53 do not, revealing that p53 also mediates a checkpoint that monitors the quality of newly replicated DNA.     

Atypical presentation of Clostridium difficile colitis in patients with cystic fibrosis

OBJECTIVE: This report describes the unusual presentation of Clostridium difficile colitis in five patients with cystic fibrosis and the role of CT in first suggesting the correct diagnosis in this group of patients. Because of the absence of watery diarrhea and the presence of abdominal bloating and decreased stooling, cystic fibrosis patients with C. difficile colitis will be treated for stool impaction, meconium ileus equivalent, or distal intestinal obstruction syndrome. CT of the abdomen, performed in these five patients because of their lack of improvement after standard therapy for stool impaction, showed an extensive pancolitis later confirmed to be caused by C. difficile infection. CONCLUSION: In patients with cystic fibrosis, imaging findings of a pancolitis should raise the possibility of C. difficile colitis despite the lack of watery diarrhea. Anticlostridial treatment can be initiated before bacteriologic confirmation is obtained.     

Cross-phase modulation in multispan WDM optical fiber systems

The spectral characteristics of cross-phase modulation (XPM) in multispan intensity-modulation direct-detection (IM-DD) optical systems are investigated, both experimentally and theoretically. XPM crosstalk levels and its spectral features are found to be strongly dependent on fiber dispersion and optical signal channel spacing. Interference between XPM-induced crosstalk effects created in different amplified fiber spans is also found to be important to determine the overall frequency response of XPM crosstalk effects. XPM crosstalk between channels with different data rates is evaluated. The crosstalk level between higher and lower bit rate channels is found to be similar to that between two lower bit rate channels. The effect of dispersion compensation on XPM crosstalk in multispan optical systems is discussed and per span dispersion compensation was found to be the most effective way to minimize the effect of XPM crosstalk     

Generation of ultrahigh-speed tunable-rate optical pulses usingstrongly gain-coupled dual-wavelength DFB laser diodes

A novel and simple method to generate a variable-rate, ultrahigh-speed optical pulse train is demonstrated using a dual-wavelength, strongly gain-coupled distributed-feedback laser diode. The repetition rate of the optical pulse train is continuously tunable from 25 to 80 GHz and no high-speed electronics are required in this method     

Pulse CO2 laser drilling of green alumina ceramic

Ceramics are used as thermal conductors and electrical insulators in integrated circuit packaging. We have investigated TEA CO₂ laser drilling of green alumina ceramic sheets consisting predominantly of alumina with approximately 10% PVB (polyvinyl butyral) as the polymer binder. Experiments with 9.5 and 10.6 μm wavelengths show that the holes made with a 9.5 μm CO₂ laser beam, where a larger percentage of the total laser energy is deposited directly into the polymer binder, are smaller, more straight-sided and cleaner