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101.
Ji Yoon Kim Seung Yoon Han Jung Yoo Go Woon Kim Yu Hyun Jeon Sang Wu Lee Jongsun Park So Hee Kwon 《International journal of molecular sciences》2022,23(15)
HDAC6 is overexpressed in ovarian cancer and is known to be correlated with tumorigenesis. Accordingly, ACY-241, a selective HDAC6 inhibitor, is currently under clinical trial and has been tested in combination with various drugs. HDAC8, another member of the HDAC family, has recently gained attention as a novel target for cancer therapy. Here, we evaluated the synergistic anticancer effects of PCI-34051 and ACY-241 in ovarian cancer. Among various ovarian cancer cells, PCI-34051 effectively suppresses cell proliferation in wild-type p53 ovarian cancer cells compared with mutant p53 ovarian cancer cells. In ovarian cancer cells harboring wild-type p53, PCI-34051 in combination with ACY-241 synergistically represses cell proliferation, enhances apoptosis, and suppresses cell migration. The expression of pro-apoptotic proteins is synergistically upregulated, whereas the expressions of anti-apoptotic proteins and metastasis-associated proteins are significantly downregulated in combination treatment. Furthermore, the level of acetyl-p53 at K381 is synergistically upregulated upon combination treatment. Overall, co-inhibition of HDAC6 and HDAC8 through selective inhibitors synergistically suppresses cancer cell proliferation and metastasis in p53 wild-type ovarian cancer cells. These results suggest a novel approach to treating ovarian cancer patients and the therapeutic potential in developing HDAC6/8 dual inhibitors. 相似文献
102.
JinMin Choi Hyung Jin Chang Yung Jun Yoo Jin Young Choi 《Computer Vision and Image Understanding》2012,116(2):179-193
To solve the problem due to fast illumination change in a visual surveillance system, we propose a novel moving object detection algorithm for which we develop an illumination change model, a chromaticity difference model, and a brightness ratio model. When fast illumination change occurs, background pixels as well as moving object pixels are detected as foreground pixels. To separate detected foreground pixels into moving object pixels and false foreground pixels, we develop a chromaticity difference model and a brightness ratio model that estimates the intensity difference and intensity ratio of false foreground pixels, respectively. These models are based on the proposed illumination change model. Based on experimental results, the proposed method shows excellent performance under various illumination change conditions while operating in real-time. 相似文献
103.
A new semantic-based video scene retrieval method is proposed in this paper. Twelve low-level features extracted from a video clip are represented in a genetic chromosome and target videos that user has in mind are retrieved by the interactive genetic algorithm through the feedback iteration. In this procedure, high-level semantic relevance between retrieved videos is accumulated with so-called semantic relevance matrix and semantic frequency matrix for each iteration, and they are combined with an automatic feature weight update scheme to retrieve more target videos at the next iteration. Experiments over 300 movie scene clips extracted from latest well-known movies, showed an user satisfaction of 0.71 at the fourth iteration for eight queries such as “gloominess”, “happiness”, “quietness”, “action”, “conversation”, “explosion”, “war”, and “car chase”. 相似文献
104.
Journal of Mechanical Science and Technology - Piezoelectric energy harvesters convert the vibration energy of a mechanical system into the electrical energy. Among them, cantilever type is the... 相似文献
105.
Sujin Cho On Hwang Iljea Lee Gayoung Lee Donghyuck Yoo Gilson Khang Peter M. Kang Dongwon Lee 《Advanced functional materials》2012,22(19):4038-4043
Hydrogen peroxide (H2O2) is one of essential oxygen metabolites in living organisms, but is generated in large amounts during inflammatory responses. Therefore, H2O2 has great potential as diagnostic and therapeutic markers of several inflammatory and life‐threatening diseases. Here, chemiluminescent and antioxidant micelles are reported as novel theranostic agents for H2O2‐associated inflammatory diseases. The chemiluminescent micelles composed of amphiphilic block copolymer Pluronic F‐127, hydroxybenzyl alcohol‐incorporated copolyoxalate (HPOX) and fluorescent dyes perform peroxalate chemiluminescence reactions to detect H2O2 as low as 100 nM and image H2O2 generated in inflamed mouse ankles. The micelles encapsulating HPOX reduce the generation of reactive oxygen species in lipopolysaccharide (LPS)‐activated macrophages by scavenging overproduced H2O2 and releasing antioxidant hydroxybenzyl alcohol (HBA). They also exert inhibitory effects on H2O2‐induced apoptosis. HPOX‐based chemiluminescent and antioxidant micelles have great potential as a theranostic agent for H2O2‐associated inflammatory diseases. 相似文献
106.
107.
Y Lee SA Lee JY Choi M Song H Sung S Joen SK Park KY Yoo DY Noh SH Ahn D Kang 《Nutrition journal》2012,11(1):59
ABSTRACT: BACKGROUND: The 5-year survival rate for breast cancer among Korean women has increased steadily; however, breast cancer remains the leading cause of cancer mortality among women. One-carbon metabolism, which requires an adequate supply of methyl group donors and B vitamins, may affect the prognosis of breast cancer. This aim of this study was to investigate the associations of dietary intake of vitamin B2, vitamin B6 and folate before diagnosis on the prognosis of breast cancer. METHODS: We assessed the dietary intake using a food frequency questionnaire with 980 women who were newly diagnosed and histopathologically confirmed to have primary breast cancer from hospitals in Korea, and 141 disease progression events occurred. Cox's proportional hazard regression models were used to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) adjusting for age, education, recruitment sites, TNM stage, hormone status, nuclear grade and total calorie. RESULTS: There was no significant association between any one-carbon metabolism related nutrients (vitamin B2, B6 and folate) and the progression of breast cancer overall. However, one-carbon metabolism related nutrients were associated with disease progression in breast cancer patients stratified by subtypes. In ER + and/or PR + breast cancers, no association was observed; however, in ER--/PR-- breast cancers, a high intake of vitamin B2 and folate statistically elevated the HR of breast cancer progression (HR = 2.28; 95% CI, 1.20-4.35, HR = 1.84; 95% CI, 1.02-3.32, respectively) compared to a low intake. This positive association between the ER/PR status and progression of the disease was profound when the nutrient intakes were categorized in a combined score (Pinteraction = 0.018). In ER--/PR-- breast cancers, high combined scores were associated with a significantly poor DFS compared to those belonging to the low score group (HR = 3.84; 95% CI, 1.70-8.71). CONCLUSIONS: In conclusion, our results suggest that one-carbon related nutrients have a role in the prognosis of breast cancer depending on the ER/PR status. 相似文献
108.
Four % (wt/wt) aqueous solutions were prepared at corn starch:methylcellulose:whey protein isolate (CS:MC:WPI) ratios of 2:2:2, 1:2:3, 2:1:3, 2:2:0, 1:2:0 and 2:1:0. Glycerol (gly) was used as a plasticiser at CS–MC–WPI:gly ratios of 2:1, 2.5:1 and 3:1. CS–MC–WPI blend films were stronger than CS–WPI films and had lower oxygen permeability (OP) than MC–WPI films. The highest tensile strength (TS) of blend films was 8.01 ± 3.41 MPa, at CS:MC:WPI ratio of 2:2:0 and CS–MC–WPI:gly ratio of 3:1. Lowest OP value was 45.05 ± 7.24 cm3 μm m?2 per day kPa?1, at CS:MC:WPI ratio of 2:2:2 and CS–MC–WPI:gly ratio of 3:1. OP values were predictable based on relative amounts of components. However, TS and elastic modulus properties of the CS–MC–WPI blend films did not reflect the relative amounts of the components. All of CS–MC–WPI films were translucent indicating some degree of immiscibility among the CS, MC and WPI. These results indicate the influence of complex molecular interactions among the components. 相似文献
109.
Recycled plastic fibre-reinforced hot-mix asphalt (HMA) mixtures have better fatigue resistance than plain HMA. The toughening effects of recycled plastic fibre-reinforced HMA were characterised using direct tensile loading tests. Adding a small quantity of recycled plastic fibres to HMA was found to significantly increase the mixture's fracture energy and toughness, which were calculated using the pre- and post-peak stages of tensile force–displacement curves. A theoretical model representing the pre-peak behaviour of fibre-reinforced HMA with direct tension-softening curves for various fibre contents is presented here. The enhanced toughness through post-peak analysis was also observed using toughness indices associated with fibre-bridging effect after the pre-peak composite stress. The pre-peak fracture energy model and post-peak toughness indices appeared to be governed by the direct tensile toughening of fibre-reinforced HMA's enhanced fibre-bridging effects. The pre-peak fracture energy model demonstrates the effect of fibre content on the strain energy density during the pull-out process within the pre-peak composite stress region. The maximum pre-peak fracture energy of a coarse-graded HMA mixed with recycled plastic fibres is achieved at a fibre content of 0.4% of the total weight of the HMA. The increases in the toughness indices within the post-peak composite stress region indicate that the fatigue resistance of fibre-reinforced HMA is at least 30% greater than that of control HMA. 相似文献
110.
Kil Sun Yoo Eun Jin Lee Daniel Leskovar Bhimanagouda S. Patil 《Journal of food science》2012,77(12):C1279-C1284
Abstract: We developed a system to run the Folin‐Ciocalteu (F‐C) total phenolic assay, in artichoke extract samples, which is fully automatic, consistent, and fast. The system uses 2 high performance liquid chromatography (HPLC) pumps, an autosampler, a column heater, a UV/Vis detector, and a data collection system. To test the system, a pump delivered 10‐fold diluted F‐C reagent solution at a rate of 0.7 mL/min, and 0.4 g/mL sodium carbonate at a rate of 2.1 mL/min. The autosampler injected 10 μL per 1.2 min, which was mixed with the F‐C reagent and heated to 65 °C while it passed through the column heater. The heated reactant was mixed with sodium carbonate and color intensity was measured by the detector at 600 nm. The data collection system recorded the color intensity, and peak area of each sample was calculated as the concentration of the total phenolic content, expressed in μg/mL as either chlorogenic acid or gallic acid. This new method had superb repeatability (0.7% CV) and a high correlation with both the manual method (r2= 0.93) and the HPLC method (r2= 0.78). Ascorbic acid and quercetin showed variable antioxidant activity, but sugars did not. This method can be efficiently applied to research that needs to test many numbers of antioxidant capacity samples with speed and accuracy. 相似文献