Remote‐Controlled Hydrogel Depots for Time‐Scheduled Vaccination

Remote‐controlled drug depots represent a highly valuable tool for the timely controlled administration of pharmaceuticals in a patient compliant manner. Here, the first pharmacologically controlled material that allows for the scheduled induction of a medical response in mice is described. To this aim, a novel, humanized biohybrid material that releases its cargo in response to a small‐molecule stimulus licensed for human use is developed. The functionality of the material in mice is demonstrated by the remote‐controlled delivery of a vaccine against the oncogenic human papillomavirus type 16. It is shown that the biohybrid depot‐mediated immunoprotection is equivalent to the classical multi‐injection‐based vaccination. These results indicate that this material can be used as a universal remote‐controlled vehicle for the patient‐compliant delivery of vaccines and pharmaceuticals.     

Characterisation of Aronia powders obtained by different drying processes

Nowadays, food industry is facing challenges connected with the preservation of the highest possible quality of fruit products obtained after processing. Attention has been drawn to Aronia fruits due to numerous health promoting properties of their products. However, processing of Aronia, like other berries, leads to difficulties that stem from the preparation process, as well as changes in the composition of bioactive compounds. Consequently, in this study, Aronia commercial juice was subjected to different drying techniques: spray drying, freeze drying and vacuum drying with the temperature range of 40–80 °C. All powders obtained had a high content of total polyphenols. Powders gained by spray drying had the highest values which corresponded to a high content of total flavonoids, total monomeric anthocyanins, cyaniding-3-glucoside and total proanthocyanidins. Analysis of the results exhibited a correlation between selected bioactive compounds and their antioxidant capacity. In conclusion, drying techniques have an impact on selected quality parameters, and different drying techniques cause changes in the content of bioactives analysed. Spray drying can be recommended for preservation of bioactives in Aronia products. Powder quality depends mainly on the process applied and parameters chosen. Therefore, Aronia powders production should be adapted to the requirements and design of the final product.     

Über Beiträge geophysikalischer Forschungen zum Umbruch der klassischen zur modernen Physik vor 100 Jahren

In 1897 physicists took the first e/m measurements at electrons, the consequence was a revival of the atomistic ideas in physics. The researches in geophysics also contributed to the construction of the modern physics. Four examples are dealt with this essay. 1) In 1899 J. J. Thomson was able to carry out the first direct determination of elementary electric charge with the help of the conformity with the natural laws at the formation of fog, found by C. T. R. Wilson. 2) The cloud-chamber, called after C. T. R. Wilson, was the result of various constructions of for- or cloud-chambers, in it there were shown for the first time the tracks of α- and β-particles. 3) At the exploration of the photoelectric effect of the sunlight (especially of the ultraviolet share) Elster and Geitel made essential preliminary studies for the lightquanta-hypothesis of Einstein. 4) Elster and Geitel detected radioactive substances in the atmosphere and in the soil to be the main source of the atmospheric electricity.      

Zur Frage der Kohlenstoffbestimmung bei emissionsspektrometrischen Verwechslungsprüfungen an Stählen

Notwendigkeit der Kohlenstoffbestimmung bei Verwechslungsprüfungen. Spektralanalytische Möglichkeiten bei Funken-und Bogenanregung in Luft. Einflüsse einiger Legierungselemente. Wiederholbarkeit und Bestimmungsgrenzen. Bestehende Forderungen.     

Aktuelle Aktivitäten zu den europäischen Rohstoff-Initiativen

The European Initiatives manifested in the Communications of the European Commission on Raw Materials, in the Strategic Implementation Plan of the European Innovation Partnership on Raw Materials and in the 2014 Call of the European Institute for Innovation & Technology (EIT) for a Knowledge and Innovation Community (KIC) on Raw Materials lead to manifold Austrian activities on Government level and on level of the Montanuniversitaet Leoben. The ESEE Region, thus East- and Southeast Europe has a special role.     

Semantische Technologien für Produktionsprozessinnovationen in der Landwirtschaft

Optimization of production processes in agriculture requires that innovation in form of efficiency enhancing devices is being continuously introduced and integrated within the production environments. This paper describes how semantic modelling, web services and automatic logical reasoning are used as system enablers for such value-adding integration in implementation of semantic-based diagnoses supporting optimization of milk production processes of dairy farms.     

Mikrofiltration von Fermenterbrühen

Microfiltration of fermentation broths . Crossflow microfiltration is a modern process for the work-up of fermentation broths. In the case of intracellular components, the cells can be enriched by this technique prior to disintegration of the cells. Extracellular products can be separated from the cells by the microfiltration membrane, and also from solids originating from the nutrient. The approach adopted in isolation of dissolved products by crossflow microfiltration is illustrated for alkaline protease, particular attention being directed to the dependence of the flow of permeate and the retention of the membrane material, the mean pore size of the membrane, the operating conditions, the physical data of the fermentation broth, and the addition of solids, which are discussed and quantified.