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31.
Although cortico steroids are effective anti-inflammatory agents in ameliorating asthma symptoms and bronchial hperreactivity, their mechanism of action is unknown. Interleukin (IL)-5 is known to play a key role in regulating eosinophil proliferation and activation. Therefore, we examined the changes of IL-5 mRNA expressions in PBMC semi-quantitatively with RT-PCR as well as serum ECP levels and MCH-PC20 values in asthmatics before and after being treated with corticosteroids. The results revealed that there were significant decrease in the level of IL-5 mRNA and serum ECP concentration after therapy (P < 0.05) and there was remarkable improvement in the values of MCH-PC20 and FEV1% (P < 0.05). It was also found that the changes of serum ECP levels or MCH-PC20 values were accompanied by a reduction in IL-5 mRNA expression (r = 0.5426 or 0.4857, P < 0.05). These results suggested that the therapeutic effects of corticosteroids in asthma may result from modulation of IL-5 gene expression with consequent inhibition of eosinophil activation. 相似文献
32.
The magnetization of a melt-texture growth (MTG) HTSC ring has been studied. It is shown that the magnetic field inside the ring is larger than the external field under a certain range of external magnetic fields. We have also investigated the magnetic field dependence of the response of a detective coil near a rotating superconducting ring. The responses of the MTG sample are different for different cooling methods. 相似文献
33.
34.
I. Belda X. Llorà E. Giralt 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2006,10(4):295-304
One of the goals of computational chemistry is the automated de novo design of bioactive molecules. Despite significant progress
in computational approaches to ligand design and efficient evaluation of binding energy, novel procedures for ligand design
are required. Evolutionary computation provides a new approach to this design issue. This paper presents an automated methodology
for computer-aided peptide design based on evolutionary algorithms. It provides an automatic tool for peptide de novo design,
based on protein surface patches defined by user. Regarding the restrictive constrains of this problem a special emphasis has been made on the design of the
evolutionary algorithms implemented. 相似文献
35.
用仿真工具优化车辆动力系统(一) 总被引:1,自引:0,他引:1
在本文的第一部分,介绍了一种理想的车辆动力系统的计算机辅助开发过程。它显示了现代仿真技术在产品持续发展过程中的作用,该技术采用硬件回路作非在线的仿真,并通过现代化的试验手段对车辆进行匹配。特别重要的是提供了将电控变速器和发动机控制单元综合的可能性。接着是在线仿真在诸如发动机和变速器模式方面的应用和发展,它是上述开发过程的基础。根据上述的方法论,本文论述了仿真技术已取得的成绩和将来的应用可能性。 相似文献
36.
The stereausis model of biological auditory processing is proposed as a representation that encodes both binaural and spectral information in a unified framework. A working analog VLSI chip that implements this model of early auditory processing in the brain is described. The chip is a 100000-transistor integrated circuit that computes the stereausis representation in real time, using continuous-time analog processing. The chip receives two audio inputs, representing sound entering the two ears, computes the stereausis representation, and generates output signals that can directly drive a color CRT display. Outputs from the chips for a variety of artificial and speech stimuli are shown. 相似文献
37.
38.
Y. G. Wang H. Q. Ye K. H. Kuo X. J. Feng S. Z. Long G. L. Lao 《Journal of Materials Science》1991,26(23):6325-6330
The microstructures of unhydrated calcium aluminosulphate Ca4Al6SO16 and Ca3SrAl6SO16 have been studied by high-resolution electron microscopy (HREM). The results showed that twinning and twinned slabs could be introduced taking the [1 1 2] direction as the twin axis so that it seems to be coincident with the law of twinning formed in body-centred cubic structures. A previously reported superlattice with a repeat period twice that of the fundamental structure along the 〈1 1 0〉 direction has also been found in both matrix and twin variants. The close intergrowth of Ca3SrAl6SO16 and another phase, possibly Sr3Al2O6 existing as an inclusion between these two twin variants, was determined and clearly revealed by electron diffraction and HREM images. The coherent interphase boundaries and orientation relationship between them can also be deduced. 相似文献
39.
The cooling and solidification of melted drops during their movement in an immiscible cooling medium is widely employed for granulation in the chemical industry, and a study of these processes to provides a basis for the design of the granulation tower height and the temperature of the cooling medium is reported. A physical model of the cooling and solidification of the drop is established and the numerical calculation is performed. The influences of the key factors in the solidification, i.e., Bi number, drop diameter, temperature of the cooling medium, etc. are presented. The cooling and solidification during wax granulation in a water‐cooling tower and during urea granulation in an air‐cooling tower (spraying tower) are described in detail. Characteristics of the solidification and temperature distribution within the particle at different times are shown. The model and calculations can be used for structure design of the granulation tower and optimization of the operation parameters. 相似文献
40.
X. S. Ning K. Suganuma T. Okamoto A. Koreeda Y. Miyamoto 《Journal of Materials Science》1989,24(8):2879-2883
Two kinds of additive-free silicon nitride ceramics were brazed with aluminium; one was with as-ground faying surfaces and
the other was with faying surfaces heat-treated at 1073K for 1.8 ksec in air. The heat-treatment of the silicon nitride ceramics
formed a silicon oxynitride layer on the faying surfaces and increased the brazing strength of the joints. A silica-alumina
non-crystalline layer and a β′-sialon layer were formed successively from the aluminium side at the interface of the joints.
The heat-treatment which made the former layer thicker is a necessary process in making reliable, strong brazed joints. 相似文献