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Nie Xin-min Gui Rong Zhao Hong-shan Ma Da-long Li Deng-qing Yuan Hong Huang Zu-fa 《中南工业大学学报(英文版)》2005,12(1):310-312
Objective Tacrolimus is an immunosuppressive drug with narrow therapeutic range and wide interindividual variation in its pharmacokinetics.
Tacrolimus is a substrate of cytochrome P450(CYP)3A5. The aim of this study was to evaluate whether the A6986G polymorphism
is associated with tacrolimus concentration /dose ratio. Methods Fifty-two Chinese renal transplant patients were enrolled in this study. Their body weight, dosage and concentration of tacrolimus
were observed. CYP3A5 genotype was determined by polymerase chain reaction followed by restriction fragment length polymorphism
analysis. Results A significant association was found between tacrolimus levels per dose/kg/d and CYP3A5 gene A6986G polymorphism (P<0.001). The CYP3A5 * 3 * 3 patients have a significantly higher tacrolimus level/dose than CYP3A5 * 1 * 1 and CYP3A5 * 1
* 3. Conclusions CYP3A5 gene A6986G polymorphism is associated with tacrolimus pharmacokinetics and dose requirements. Pharmacogenetic methods
could be employed prospectively to help the dose selection and to individualize immunosuppressive therapy according to the
result.
Foundation item: Project (03GZ3072) supported by the Science and Technology Department of Hunan Province; project (2004035206) supported by
the China Postdoctoral Foundation and project (30300383) supported by the National Natural Sciences Foundation of China 相似文献
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Xue‐Bing Zhao Lei Wang De‐Hua Liu 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2008,83(6):950-956
Previous work has shown that the enzymatic hydrolysis of sugarcane bagasse could be greatly enhanced by peracetic acid (PAA) pretreatment. There are several factors affecting the enzymatic digestibility of the biomass, including lignin and hemicelluloses content, cellulose crystallinity, acetyl group content, accessible surface area and so on. The objective of this work is to analyze the mechanism of the enhancement of enzymatic digestibility caused by PAA pretreatment. Delignification resulted in an increase of the surface area and reduction of the irreversible absorption of cellulase, which helped to increase the enzymatic digestibility. The Fourier transform infrared (FTIR) spectrum showed that the absorption peaks of aromatic skeletal vibrations were weakened or disappeared after PAA pretreatment. However, the infrared crystallization index (N.O'KI) was increased. X‐ray diffraction (XRD) analysis indicated that the crystallinity of PAA‐treated samples was increased owing to the partial removal of amorphous lignin and hemicelluloses and probable physical change of cellulose. The effect of acetyl group content on enzymatic digestibility is negligible compared with the degree of delignification and crystallinity. The results indicate that enhancement of enzymatic digestibility of sugarcane bagasse by PAA pretreatment is achieved mainly by delignification and an increase in the surface area and exposure of cellulose fibers. Copyright © 2008 Society of Chemical Industry 相似文献
207.
Shi Wei Zhao Xuefeng Ma Conghui Management of the National Development Reform Commission 《中国通信》2008,(3)
After the new round of restructuring of Chinese telecom sector,it's pressing to formulate and implement asymmetric regulation policies so as to shape an effectively competitive market structure in a relatively short term.This paper reviewed the asymmetric regulation policies and practices carried out in foreign telecom market,and then according to the specific situations of Chinese telecom market,proposed the principles and corresponding policies for establishing an asymmetric regulation system fit for Chin... 相似文献
208.
依据《建筑给水排水设计规范》(GB50015—2003)中相关条款,编制不同设计参数条件下的住宅建筑设计秒流量计算方案,并通过对计算数据的统计分析,总结了影响设计秒流量公式计算结果的主要因素及公式特征。最后探讨了规范公式适用条件存在的问题。 相似文献
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Song Xiao-chun Huang Song-ling Zhao Wei 《Russian Journal of Nondestructive Testing》2007,43(5):326-331
Magnetization is the key to inspection of a tank floor via the magnetic-flux-leakage (MFL) technique. In order to optimize
the magnetic circuit of the MFL detector and obtain the best detection effects, the influences of the magnet size on the floor
magnetization condition, the gap magnetic flux density, and the magnetic force were studied with the help of the finite element
method (FEM) and the effects of some other parameters, such as the magnet pole spacing and pole-piece thickness, on the signal-to-noise
ratio were analyzed. The simulation results indicate that variation of the magnet width affects the magnetization much more
than variation of the magnet thickness and that the detector can reach a trade-off between the magnetization effects and the
driving force when the magnet is about 30 mm thick and 40 mm wide. On condition that the floor has reached its magnetizing
saturation, an increase in the magnet-pole spacing and the pole-piece thickness can improve the testing sensitivity and the
signal-to-noise ratio.
The text was submitted by the authors in English. 相似文献