Current status of researches on the plutonium rock-like oxide fuel and its burning in light water reactors

Intention of the ROX-LWR system research is to provide an option for utilization or disposition of surplus plutonium. Researches on inert matrix materials and irradiation performance shows that the most favorable candidate for the ROX fuel is a particle dispersed fuel where small particles consisted of yttria stabilized zirconia, PuO₂ and some additives are homogeneously dispersed in spinel matrix. Reactor safety analyses show that the ROX fueled PWR core has nearly the same performability as the existing UO₂ fueled PWR under both reactivity initiated accidents and loss of coolant accidents.     

A refined algorithm for finite-difference synthesis of cam profiles

The present paper deals with the synthesis of a cam profile when the prescribed acceleration pattern is given in numerical form. It is primarily an extension of previous work by the author with a view to upgrading the numerical accuracy of the synthesized cam profile, hence broadening the scope of application to a general class of high-speed cams. The technique is to differentiate the Stirling interpolation formula or the Gregory-Newton interpolation formula, thereby refining the prescribed initial acceleration data so that it will be correct to differences of high order. The effectiveness and the accuracy of this technique is demonstrated by a numerical example.     

具有延迟特性的倾斜镜系统中速度-位置控制方法

在基于图像传感器的倾斜镜控制系统中,由于传感器采样频率和系统延时的影响,限制了系统的闭环性能和控制带宽。在有限带宽的条件下,本文提出利用光栅尺测量位置,差分得到速度,实现基于图像传感器系统的速度-位置反馈控制,从而提升倾斜镜控制系统的误差抑制能力。速度反馈环节的引入,使控制系统呈微分特性,当速度反馈闭环完成后,图像位置回路具有积分特性,此时使用PI控制器稳定系统,从而使得系统从零型上升为二型系统,提升系统的误差抑制能力。仿真和实验都证明这种方法可以有效地提高跟踪控制系统的闭环性能。     

融合常用语的大规模疾病术语图谱构建

国家卫计委要求医疗机构使用国际疾病分类(international classification of diseases, ICD)编码,然而由于临床疾病描述存在大量的常用词,导致电子病历中录入的诊断名称与ICD编码直接映射匹配率低.基于区域健康平台上的真实诊断数据,构建了融合常用语的疾病术语图谱.具体来说,在基于疾病构成成分的规则算法基础上,提出了基于数据增强的BERT(bidirectional encoder representation from transformers)上下位关系识别算法,将5万多个诊断常用语和ICD10(international classification of diseases 10th revision,Chinese version)中的疾病进行同义关系和上下位关系识别,进一步融合了ICD11(international classification of diseases 11th revision,Chinese version)的层次结构,此外,还提出了基于疾病-科室关联图谱的任务分配方法以进行人工校验,最终94 478个疾病实体形成了包含1 460条同义关系、46 508条上下位关系的大规模疾病术语图谱.评估实验表明,基于疾病术语图谱,对临床诊断数据的覆盖率比基于ICD10的直接映射编码的覆盖率提升了75.31%,另外,利用疾病术语图谱自动进行编码疾病相比于医生人工编码会缩短约59.75%的编码时间,且正确率达到85%.
     

Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity

Tumor necrosis factor (TNF) inhibitors (anti-TNFs) represent a cornerstone of the treatment of various immune-mediated inflammatory diseases and are among the most commercially successful therapeutic agents. Knowledge of TNF binding partners is critical for identification of the factors able to affect clinical efficacy of the anti-TNFs. Here, we report that among eighteen representatives of the multifunctional S100 protein family, only S100A11, S100A12 and S100A13 interact with the soluble form of TNF (sTNF) in vitro. The lowest equilibrium dissociation constants (K_d) for the complexes with monomeric sTNF determined using surface plasmon resonance spectroscopy range from 2 nM to 28 nM. The apparent K_d values for the complexes of multimeric sTNF with S100A11/A12 estimated from fluorimetric titrations are 0.1–0.3 µM. S100A12/A13 suppress the cytotoxic activity of sTNF against Huh-7 cells, as evidenced by the MTT assay. Structural modeling indicates that the sTNF-S100 interactions may interfere with the sTNF recognition by the therapeutic anti-TNFs. Bioinformatics analysis reveals dysregulation of TNF and S100A11/A12/A13 in numerous disorders. Overall, we have shown a novel potential regulatory role of the extracellular forms of specific S100 proteins that may affect the efficacy of anti-TNF treatment in various diseases.