Dynamics of glucose-induced insulin release from mouse islets transplanted under the kidney capsule

Mouse pancreatic islet grafts under the kidney capsule of syngeneic hosts were removed and perifused in vitro 1-40 weeks after the transplantation. In comparison with fresh islets, 12- to 40-week-old grafts exhibited an attenuated first phase of glucose-stimulated insulin release. In grafts 1, 12, 28, or 40 weeks old, but not in fresh islets, the mean secretory rate during the initial 10 min of stimulation was significantly lower than that during the subsequent 15 min. When expressed in relation to insulin content, the insulin output in response to 11 mmol/L glucose was no less from grafts than from fresh islets; in grafts 12 or 40 weeks old at 16.7 mmol/L glucose, the fractional output above baseline was significantly diminished during the initial 10 min, but not subsequently. Immediately on switching from basal to stimulatory glucose concentration, there was a transient drop in insulin secretion from the grafts, especially after more than 12 weeks of transplantation and in response to 16.7, as compared with 11, mmol/L glucose. When glucose was switched back from stimulatory to basal concentration, grafts also frequently exhibited a transient increase in the insulin secretory rate. Neither initial drops nor "off responses" were seen in untransplanted islets. The modifications of the secretory dynamics in islet grafts suggest that transplantation influences the balance between the stimulatory and inhibitory influences of glucose on the beta-cell's secretory machinery.     

Infective endocarditis complicated with rapidly progressive glomerulonephritis: a case report

Despite a general national decline in criminal activities in the 1990s, juvenile criminal offenses continue to increase, (including violent, property, and delinquency acts). In addition increased numbers of children are being held in juvenile jails. It is all but impossible for pediatric health providers to think that "their patients" and "their practices" are immune from the epidemic of crime that affects and is caused by "just kids."     

CHL1 encodes a component of the low-affinity nitrate uptake system in Arabidopsis and shows cell type-specific expression in roots

The Arabidopsis CHL1 (AtNRT1) gene confers sensitivity to the herbicide chlorate and encodes a nitrate-regulated nitrate transporter. However, how CHL1 participates in nitrate uptake in plants is not yet clear. In this study, we examined the in vivo function of CHL1 with in vivo uptake measurements and in situ hybridization experiments. Under most conditions tested, the amount of nitrate uptake by a chl1 deletion mutant was found to be significantly less than that of the wild type. This uptake deficiency was reversed when a CHL1 cDNA clone driven by the cauliflower mosaic virus 35S promoter was expressed in transgenic chl1 plants. Furthermore, tissue-specific expression patterns showed that near the root tip, CHL1 mRNA is found primarily in the epidermis, but further from the root tip, the mRNA is found in the cortex or endodermis. These results are consistent with the involvement of CHL1 in nitrate uptake at different stages of root cell development. A functional analysis in Xenopus oocytes indicated that CHL1 is a low-affinity nitrate transporter with a K(m) value of approximately 8.5 mM for nitrate. This finding is consistent with the chlorate resistance phenotype of chl1 mutants. However, these results do not fit the current model of a single, constitutive component for the low-affinity uptake system. To reconcile this discrepancy and the complex uptake behavior observed, we propose a "two-gene" model for the low-affinity nitrate uptake system of Arabidopsis.     

基于Flash的高速数据记录器的研究与设计

介绍了一种基于Flash的高速数据记录器的实现方案;采用了双片选、交替双平面编程技术,并对视频数据进行总线拓宽,采用双口RAM存取无效块地址的方式,从而整体提高了存储的速度,突破了存储芯片的瓶颈,成功实现以66MB/s的速度实时存储视频数据,完全满足速率为59.6MB/s数据的写入要求;采用LVDS驱动及解串芯片相配合,并对传输线进行阻抗匹配,有效保证了信号数据的可靠接收和存储;该数据记录器已通过温度循环试验、高温老练试验、电磁兼容试验、振动试验等,性能稳定,能够实现数据的可靠存储,完全满足工程实践的要求.     

基于多目视觉的变形钢板三维测量方法

提出了一种使用4个相机测量变形钢板三维形状的方法;在没有纹理的钢板上画一些点,使用4个相机同时拍摄钢板;利用边缘检测算法找出钢板的边缘,利用特征点提取算法提取出4个图像中钢板上的特征点,并找到4个图像上精确的特征点匹配关系,然后测量出这些特征点的三维点;最后,以这些三维点为种子点向外区域增长,从而得到钢板的三维形状;实验对变形钢板进行三维测量,得到了钢板的精确的三维形状,结果验证了该方法的有效性和可行性。     

参数未知的自适应耦合同步及其在保密通信中的应用

在实际应用中,系统参数会随着环境的变化而变化,因此研究参数不确定混沌系统的同步更具有实际应用价值。文章针对参数完全未知的混沌系统,基于单向耦合同步方法,实现了混沌系统的自适应同步,为证明系统同步进行了严格的数学推导,并将同步的混沌系统应用到混沌保密通信中。计算机仿真表明混沌系统能够快速达到同步,且在混沌保密通信系统的接收端,有用信号可以有效地恢复出来,从而证明文章提出的方法有效且可行。     

面向动态模糊数据的关系数据库系统的研究

为使关系数据库系统具备处理动态模糊数据的能力,将动态模糊理论和关系数据库理论相结合,通过分析面向动态模糊数据的关系数据库系统的功能,构造了该数据库的系统结构,探讨了实现该数据库的方法,对面向动态模糊数据的关系数据库系统做了初步的研究。     

Fault-tolerant control for a class of nonlinear sampled-data systems via a Euler approximate observer

In this paper, a fault-tolerant control (FTC) scheme is developed for a class of nonlinear sampled-data systems. First, a Euler approximate discrete model is used to describe the plant under the sampling. Under this model, an observer-based fault estimation method is proposed. To guarantee the accuracy of both the state and fault estimation values, the conditions to make the approximate model consistent with the exact model are presented. Then, an active fault-tolerant controller, which has a constraint condition for the sampling time, is designed to make the faulty system stable. Finally, an inverted pendulum is used to show the efficiency of the proposed method.     

A modified Guruswami-Sudan algorithm for decoding Reed-Solomon codes

We tighten a key estimate, which dictates the computational complexity of Guruswami-Sudan algorithm, on the lower bound of the degrees of freedom, and then propose a modified decoding algorithm for Reed-Solomon codes beyond half the minimum distance. The computational complexity of the modified algorithm is lower than the Guruswami-Sudan algorithm for the medium to high rate Reed-Solomon codes, and has the same asymptotic complexity as the algorithm proposed by Wu. Besides we also claim that our modified algorithm outperforms Wu's algorithm to some extent.