Brief bimanual force pulses: Correlations between the hands in force and time.

Three experiments assessed coupling phenomena in the coordination of bimanual force pulses. Experiment 1 required symmetric force pulses (equal target forces and rise times for both hands) using the index finger of each hand. As the authors expected, on the basis of bimanual pointing movement results, this experiment revealed positive correlations between both the force rise times and the force amplitudes of the two hands. Experiments 2 and 3 included asymmetric conditions with different target force amplitudes (Experiment 2) or target rise times (Experiment 3). In Experiment 2 force amplitudes but not rise times were fully decoupled in the asymmetric condition. In the asymmetric condition of Experiment 3, however, neither rise times nor force amplitudes were fully decoupled. The results suggest a hierarchical control structure with temporal control dominating nontemporal control of bimanual force coordination. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The membrane affinities of the aliphatic amino acid side chains in an alpha-helical context are independent of membrane immersion depth

Understanding, predicting, and designing the binding of peptides and proteins to bilayers require quantifying the intrinsic propensities of individual amino acid residues to bind membranes as a function of structural context and bilayer depth. A host-guest study was performed using the peptide host named helix5 in order to determine the membrane affinities of the aliphatic side chains both in an alpha-helical context and as a function of bilayer depth. Use of the alpha-helical host with a constrained geometry allowed the placement of guest sites at three different depths in bilayers and minimized secondary structural changes due to guest substitutions. Circular dichroism and electron paramagnetic resonance (EPR) were used to characterize the aqueous and bilayer-bound structures of the peptide variants. EPR was also used to measure the bilayer-water partition constants of the peptide variants, and the Delta DeltaGtr values (relative to Gly) of the aliphatic amino acid side chains were subsequently calculated. Surprisingly, the DeltaDeltaGtr values did not significantly vary as a function of the guest site depth in bilayers. In addition, the Delta DeltaGtr values determined in an alpha-helical context are reduced to approximately two-thirds of Delta DeltaGtr values determined in other studies for the bilayer-water and octanol-water partitioning of amino acid side chains in extended and unstructured hosts. Both the relative reduction in Delta DeltaGtr values in the context of an alpha-helical host and the invariance of Delta DeltaGtr values with respect to bilayer depth are consistent with the membrane affinities of the aliphatic residues being largely determined by the classical hydrophobic effect.     

Effect of parent weight on weight loss in obese children.

Assessed the effect of parent weight (obese/nonobese parent) and parent control vs child self-control on the weight loss of 41 obese 8–12 yr olds over a 3-yr period. Children of nonobese parents had significantly greater decrease in relative weight after 1 yr, but not after 3 yrs, than children of obese parents. Locus of control was not related to treatment outcome over the 3 yrs. Results suggest that parent weight was related to weight loss, but not weight maintenance, in obese children. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Attracting student participation in asynchronous online discussions: A case study of peer facilitation

Previous research studies on how to promote student participation in asynchronous online discussions have largely focused on the role of the instructor or tutor as facilitators. Not many investigated student facilitation. This article reports a qualitative study examining the facilitation techniques used by student facilitators to attract their course mates to participate in asynchronous online discussions. Data were collected from the students’ reflection logs and students’ online postings. To explore the extent to which student participation in an online discussion forum is successful, we looked at the depth of discussion threads. We deemed a student facilitator to have successfully attracted other students to participant if the discussion threads had a depth of six or more levels of students’ postings. We then examined in detail and reported the facilitation techniques that were exhibited by the student facilitators. Results showed that seven facilitation techniques were employed; the most frequently used were Socratic questioning and sharing personal opinions or experiences. We end by exploring potential implications for practice and for future research.     

Genetic effects on dairy calf growth

Objectives were to establish growth patterns for weight and height in dairy calves from birth to 90 d and to estimate appropriate genetic parameters. Measurements were 7943 body weights and 7005 wither heights of 752 calves. Represented over 12 yr were three breeds, 348 dams, and 115 sires; data resulted from designed calf nutrition experiments. Sources of variation considered in various least squares analyses of variance were breed, sire in breed, calf in sire in breed, sex of calf, treatment-year category, and several interactions. Repeatabilities of weights and heights between birth and 90 d were .64 and .88; heritabilities were .22 and .30; genetic and phenotypic correlations were .53 and .73. A regression equation was estimated for each calf. From these 752 equations, heritabilities of initial weight, initial height, and rates of growth in weight and height were .53, .50, .44, and .19. Genetic correlations were .81; -.07; -.05; .26; .14; .84. Selection schemes for these traits in dairy cattle should consider that although weights and heights at birth and thereafter are highly and positively correlated genetically, as are gains, birth measurements and gains to 90 d may be uncorrelated.     

Benign and malignant esophageal strictures: treatment with a polyurethane-covered retrievable expandable metallic stent

PURPOSE: To evaluate the clinical effectiveness of a polyurethane-covered, retrievable, self-expandable metallic stent and hook catheter in the treatment of esophageal strictures. MATERIALS AND METHODS: Stents were constructed of 0.4-mm stainless steel wire in a cylindric zig-zag configuration of six to nine bends. Four to eight stents were connected in tandem by dipping in a polyurethane solution. A nylon loop was hooked inside to each bend of the proximal portion of the stent and strung with a thread. Under fluoroscopic guidance, 22 stents were placed in 16 patients with a malignant stricture and five patients with a benign stricture. The stent was removed with a hook catheter 2 months after placement in patients with a benign stricture and when complications occurred in patients with a malignant stricture. All patients had dysphagia with ingestion of soft foods or liquids. RESULTS: Stent placement was technically successful and well tolerated in 20 patients. In one patient, the stent was misplaced but relocated successfully. After stent placement, all patients were able to ingest solid and/or soft foods without dysphagia. After stent removal, strictures showed improvement but recurred in two patients. CONCLUSION: Use of polyurethane-covered, retrievable expandable stents seems to be a feasible and effective method of treatment of benign and malignant esophageal strictures.     

REM sleep behaviour disorder: an overview

REM sleep behaviour disorder (RSBD) is a recently described parasomnia characterised by a history of excessive nocturnal motor activity and absence of muscle atonia during REM sleep. Only limited literature is available on this condition. The exact prevalence is unclear, but recent studies suggest it might not be an uncommon condition. The elderly are more often affected and there is a male preponderance. While transient RSBD can be seen after taking certain drugs or during drug withdrawal, the chronic type is usually idiopathic or associated with an underlying degenerative neurological condition. It can result in considerable distress and/or serious injury to the patients or their bed partners. Differential diagnoses include sleep-walking, night terrors, nightmares, nocturnal seizures, obstructive sleep apnoea, post-traumatic stress disorder, dissociative states and nocturnal confusional states. The dramatic response to clonazepam highlights the importance of recognition and appropriate treatment of this sleep disorder.     

Interval-graph-based PLA folding

In this paper we present algorithms to implement PLA folding based on the interval graph theory. A PLA will be represented by five sets of nets: product-term nets (PT nets), input and output nets (I and O nets), and input and output connection nets (IC and OC nets). Column folding becomes a problem of permuting the rows such that the I/O nets can be placed in as few columns as possible. Algorithms for both unconstrained and constrained foldings are given.