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41.
Ordering clones from a genomic library into physical maps of whole chromosomes presents a central computational problem in
genetics. Chromosome reconstruction via clone ordering is shown to be isomorphic to the classical NP-complete Optimal Linear
Arrangement problem. Parallel algorithms for simulated annealing and microcanonical annealing based on Markov chain decomposition
are proposed and applied to the problem of chromosome reconstruction via clone ordering. These algorithms are implemented
on a cluster of UNIX workstations using the Parallel Virtual Machine (PVM) system. PVM is a software system that permits a
heterogeneous collection of networked computers to be viewed by a user's program as a single monolithic parallel computing
resource. The parallel algorithms are implemented and tested on clonal data derived from Chromosome IV of the fungus Asperigillus
nidulans Perturbation methods and problem-specific annealing heuristics for the parallel simulated annealing and parallel
microcanonical annealing algorithms are proposed and described. Convergence, speedup and scalability characteristics of the
various parallel algorithms are analyzed and discussed.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
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This paper presents an experimental study of rarefied gas flow in a trapezoidal microchannel with a constant depth of 103 µm, top width of 1143 µm, bottom width of 998 µm and length of 2 cm. The aim of the study is to verify the upper limit of the validity of the second-order slip boundary condition to model rarefied gas flows. The slip coefficients and the tangential momentum accommodation coefficient (TMAC) are determined for three different gases, viz. argon, nitrogen and oxygen, and it is observed that they compare well to the literature values. The range of mean Knudsen number (Knm) investigated is 0.007–1.2. The non-dimensional mass flow rate exhibits the well-known Knudsen minimum in the transition regime (Knm?~?1). It is seen that the Navier–Stokes equation with a second-order boundary condition fits the data satisfactorily with a high value of correlation coefficient (r2?>?99.95%) in the entire range of Knm investigated. This work contributes by extending the range of Knudsen number studied in the context of validity of the second-order slip boundary condition. 相似文献
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A method for studying the controllability of a linear time-invariant system by considering the controllability of a smaller subsystem is proposed. The method is most effective when the system under study has a large number of inputs and states. 相似文献
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48.
M. Dilip Bhandarkar M. Shanthidas Bhat Earl R. Parker Victor F. Zackay 《Metallurgical and Materials Transactions A》1976,7(5):753-760
The microstructural changes which occurred during creep were examined in a carbon-free ferritic alloy containing 1 at. pct Ta and 7 at. pct Cr. The alloy derived its creep resistance from a uniform dispersion of almost spherical particles of the Laves phase Fe2Ta in a bcc matrix. There was a lath-like substructure in this alloy, with dislocation tangles and subgrains within the laths. Partial recovery during creep led to the formation of a regular subgrain structure. The Laves phase particles prevented total recovery by pinning individual dislocations and subgrain boundaries. The apparent activation energy for creep, the estimated stress sensitivity of minimum creep rate, and the substructural features observed in crept specimens suggested that creep deformation of the alloy occurred by two or more independent processes. Fracture under creep conditions was initiated by void formation at precipitate-matrix interfaces. Intergranular void formation played an important role in the fracture of creep specimens tested at 1200°F (649°C), but not at lower temperatures. 相似文献
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Suchendra M. Bhandarkar Xingzhi Luo Richard Daniels E. William Tollner 《Pattern Analysis & Applications》2006,9(2-3):155-175
A novel feature-based tracking approach based on the Kalman filter is proposed for the detection, localization, and 3-D reconstruction of internal defects in hardwood logs from cross-sectional computer tomography (CT) images. The defects are simultaneously detected, classified, localized, and reconstructed in 3-D space, making the proposed scheme computationally much more efficient than existing methods where the defects are detected and localized independently in individual CT image slices and the 3-D reconstruction of the defects accomplished via correspondence analysis across the various CT image slices. Robust techniques for defect detection and classification are proposed. Defect class-specific tracking schemes based on the Kalman filter, B-spline contour approximation, and Snakes contour fitting are designed which use the geometric parameters of the defect contours as the tracking variables. Experimental results on cross-sectional CT images of hardwood logs from select species such as white ash, hard maple, and red oak are presented. 相似文献