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91.
A simple two-parameter model of the monthly demand for natural gas for space heating is developed. First, a simple indicator of the coldness of the month labeled “modified degree days” is presented. Both aggregate monthly demand and monthly demand for a single unit are modeled as a function of this indicator. The model has two parameters, a reference temperature which reflects the internal temperature and free heat contribution and a slope parameter which reflects the thermal behavior of the dwelling. Variation in these two parameters is related to characteristics of the dwelling. Finally, the effect of the onset of the energy crisis on the two parameters is assessed.  相似文献   
92.
    
Selectively targeted drug delivery systems are preferable chemotherapeutic platforms, as they specifically deliver the drug cargo into tumor cells, while minimizing untoward toxic effects. However, these delivery systems suffer from insufficient encapsulation efficiency (EE), encapsulation capacity (EC), and premature drug release. Herein, we coencapsulated paclitaxel (PTX) and Jasmine oil (JO) within PEG-PCL nanoparticles (NPs), with an average diameter < 50 nm, selectively targeted to non-small cell lung cancer (NSCLC) cells, via S15-aptamer (APT) decoration. JO was selected as an “adhesive” oily core to enhance PTX entrapment, as JO and PTX share similar hydrophobicity and terpenoid structure. JO markedly enhanced EE of PTX from 23% to 87.8% and EC from 35 ± 6 to 74 ± 8 µg PTX/mg PEG-PCL. JO also markedly increased the residual amount of PTX after 69 h, from 18.3% to 65%. Moreover, PTX cytotoxicity against human NSCLC A549 cells was significantly enhanced due to the co-encapsulation with JO; the IC50 value for PTX encapsulated within JO-containing APT-NPs was 20-fold lower than that for APT-NPs lacking JO. Remarkably, JO-containing APT-NPs displayed a 6-fold more potent cell-killing, relatively to the free-drug. Collectively, these findings reveal a marked synergistic contribution of JO to the cytotoxic activity of APT-NP-based systems, for targeted PTX delivery against NSCLC, which may be readily applied to various hydrophobic chemotherapeutics.  相似文献   
93.
    
Field‐effect transistors (FET) are largely based on single crystals, amorphous films, or multiple (poly)crystalline layers. The single crystal that is known to exhibit the best performance in terms of mobility and stability is in fact only scarcely used in organic electronics, let alone in the context of low‐cost printing. Here a new FET design is presented, the statistical FET (SFET), which through a single additive step, requiring no alignment of the crystals with respect to the electrodes, can overcome the limitations imposed by the standard FET structure. This enables the use of crystal forming molecules in an additive manufacturing process, as printing is. This extra additive step can be utilized in passivating grain boundary related traps or dedoping. Several SFET onfigutrations are using several crystal forming molecules. This new structure may shift the synthetic effort toward crystal‐forming molecules.  相似文献   
94.
de-Bashan LE  Bashan Y 《Water research》2004,38(19):4222-4246
Large quantities of phosphate present in wastewater is one of the main causes of eutrophication that negatively affects many natural water bodies, both fresh water and marine. It is desirable that water treatment facilities remove phosphorus from the wastewater before they are returned to the environment. Total removal or at least a significant reduction of phosphorus is obligatory, if not always fulfilled, in most countries. This comprehensive review summarizes the current status in phosphorus-removal technologies from the most common approaches, like metal precipitation, constructed wetland systems, adsorption by various microorganisms either in a free state or immobilized in polysaccharide gels, to enhanced biological phosphorus removal using activated sludge systems, and several innovative engineering solutions. As chemical precipitation renders the precipitates difficult, if not impossible, to recycle in an economical industrial manner, biological removal opens opportunities for recovering most of the phosphorus and beneficial applications of the product. This review includes the options of struvite (ammonium-magnesium-phosphate) and hydroxyapatite formation and other feasible options using, the now largely regarded contaminant, phosphorus in wastewater, as a raw material for the fertilizer industry. Besides updating our knowledge, this review critically evaluates the advantage and difficulties behind each treatment and indicates some of the most relevant open questions for future research.  相似文献   
95.
Coimmobilization of the freshwater microalga Chlorella vulgaris in alginate beads with the microalgae growth-promoting bacterium Azospirillum brasilense under semi-continuous synthetic wastewater culture conditions significantly increased the removal of ammonium and soluble phosphorus ions compared to immobilization of the microalgae alone. In continuous or batch cultures removal of these ions followed a similar trend but was less efficient than in semi-continuous culture. It is proposed that coimmobilization of a microalgae with microalgae growth-promoting bacteria can serve as a tool in devising novel wastewater treatments.  相似文献   
96.
Positive moods promote a focus on the forest (global focus) and negative moods, a focus on the trees (local focus). Is this well-established link fixed or variable? Does it reflect a direct influence of affect, as usually assumed, or is it frequently observed simply because a global perspective is often dominant? If affect serves as information about the value of currently accessible inclinations, and a global focus is generally the default perspective, then the global focus of positive affect and local focus of negative affect might be variable rather than fixed. Two experiments tested this hypothesis using different mood inductions, different tests of global–local focus, and different methods of inducing global and local perspectives. In each, we discovered that positive affect empowered whatever focus was momentarily dominant. Thus, whether individuals in happy moods saw the forest or the trees depended only on which of the two had been primed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
97.
In this paper, we investigate the problem of localization of a diffusive point source of gas based on binary observations provided by a distributed chemical sensor network. We motivate the use of the maximum likelihood (ML) estimator for this scenario by proving that it is consistent and asymptotically efficient, when the density of the sensors becomes infinite. We utilize two different estimation approaches, ML estimation based on all the observations (i.e., batch processing) and approximate ML estimation using only new observations and the previous estimate (i.e., real time processing). The performance of these estimators is compared with theoretical bounds and is shown to achieve excellent performance, even with a finite number of sensors  相似文献   
98.
    
According to the Water Authority of Israel, Israel's water economy is on the brink of a crisis. Demands are increasing, exceeding the capacity of the natural sources, which are being depleted. Water, as a resource in short supply, necessitated administrative actions in order to attain its efficient utilization, in accordance with the goals set by the state. In addition, the issue of water allocation in Israel is strongly connected to internal politics and not necessarily to a clear overall policy. This article presents a simulation model which examined a large number of different scenarios and returns the possible outcomes of water allocations in a routine situation of uncertainty. The findings show that even under ideal conditions, a water shortage in Israel is inevitable and urban consumption will demand the largest allocation of water. As a result, the Israeli rural sector will be required to reorganize the water allocation system and production structure.  相似文献   
99.
We introduce the notion of fault tolerant mechanism design, which extends the standard game theoretic framework of mechanism design to allow for uncertainty about execution. Specifically, we define the problem of task allocation in which the private information of the agents is not only their costs of attempting the tasks but also their probabilities of failure. For several different instances of this setting we present both, positive results in the form of mechanisms that are incentive compatible, individually rational, and efficient, and negative results in the form of impossibility theorems.  相似文献   
100.
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