Remote‐Loaded Platelet Vesicles for Disease‐Targeted Delivery of Therapeutics

The recent emergence of biomimetic nanotechnology has facilitated the development of next‐generation nanodelivery systems capable of enhanced biointerfacing. In particular, the direct use of natural cell membranes can enable multivalent targeting functionalities. Herein, this study reports on the remote loading of small molecule therapeutics into cholesterol‐enriched platelet membrane‐derived vesicles for disease‐targeted delivery. Using this approach, high loading yields for two model drugs, doxorubicin and vancomycin, are achieved. Leveraging the surface markers found on platelet membranes, the resultant nanoformulations demonstrate natural affinity toward both breast cancer cells and methicillin‐resistant Staphylococcus aureus. In vivo, this translates to improved disease targeting, increasing the potency of the encapsulated drug payloads compared with free drugs and the corresponding nontargeted nanoformulations. Overall, this work demonstrates that the remote loading of drugs into functional platelet membrane‐derived vesicles is a facile means of fabricating targeted nanoformulations, an approach that can be easily generalized to other cell types in the future.     

Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer

The booming development of nanomedicine offers great opportunities for cancer diagnostics and therapeutics. Herein, a magnetic targeting‐enhanced cancer theranostic strategy using a multifunctional magnetic‐plasmonic nano‐agent is developed, and a highly effective in vivo tumor photothermal therapy, which is carefully planed based on magnetic resonance (MR)/photoacoustic (PA) multimodal imaging, is realized. By applying an external magnetic field (MF) focused on the targeted tumor, a magnetic targeting mediated enhanced permeability and retention (MT‐EPR) effect is observed. While MR scanning provides tumor localization and reveals time‐dependent tumor homing of nanoparticles for therapeutic planning, photoacoustic imaging with higher spatial resolution allows noninvasive fine tumor margin delineation and vivid visualization of three dimensional distributions of theranostic nanoparticles inside the tumor. Utilizing the near‐infrared (NIR) plasmonic absorbance of those nanoparticles, selective photothermal tumor ablation, whose efficacy is predicted by real‐time infrared thermal imaging intra‐therapeutically, is carried out and then monitored by MR imaging for post‐treatment prognosis. Overall, this study illustrates the concept of imaging‐guided MF‐targeted photothermal therapy based on a multifunctional nano‐agent, aiming at optimizing therapeutic planning to achieve the most efficient cancer therapy.     

GaAs基通孔刻蚀的崩边形成机理研究

在砷化镓(GaAs)集成无源器件(Integrated Passive Device, IPD)的制作工艺中,通孔刻蚀是一道重要环节。蚀刻孔边缘的GaAs会被蚀刻,由此引发崩边并对器件性能及可靠性造成不利影响。本文中,用于通孔蚀刻的GaAs厚度不小于200 μm,通孔边缘没有被蚀刻的痕迹,以实现金属导线的平滑连接。采用光阻和金属来充当掩膜,有效解决了单一光阻因厚度过高而变形或者厚度薄导致GaAs衬底被蚀刻的问题。通过优化工艺,在光阻厚度为32 μm、金属掩膜厚度为0.5 μm、金属蚀刻时间为60 s以及感应耦合等离子体(Inductively Couple Plasma, ICP)蚀刻4000 s的条件下,得到了孔深为200 μm且通孔边缘平整的形貌。分析了 GaAs 崩边形成的主要原因与机理,并通过优化工艺解决了200 μm通孔的崩边问题,从而提高了器件性能及可靠性。     

脉冲激光热力冲击效应对电沉积的作用

脉冲激光电化学复合沉积利用激光的热力冲击效应可以有效提高沉积效率,改善加工质量。在所构建的纳秒脉冲激光电化学沉积加工系统中,利用激光辐照和电化学沉积的方法对铜进行了复合沉积试验。分析了激光的热力冲击效应对电沉积的作用机理,激光产生的力效应使阴极基片发生弹性变形,改变了电极电势和电流密度,提高了电沉积质量。通过加工试验,研究了激光平均功率密度对沉积质量和沉积效率的影响,并进行了讨论。试验结果表明,激光平均功率密度介于100~400 kW/cm2时可以获得较好的沉积层质量。激光平均功率密度在200 kW/cm2左右,沉积速率取得最大值。     

面向扑翼微飞行器的扭矩传感器研究

由于仿昆虫扑翼微飞行器需要在小范围内传输扭矩,且扭矩数值较小,一般的扭矩传感器或力传感器在其动态范围内均难以达到测量精度的要求。为了解决这一问题,提出了一种新型单轴扭矩传感器的设计方案,并完成了实际的制造和测试。该扭矩传感器的主体为殷钢材料,由激光加工制作而成,利用电容式位移传感器测量主轴旋转时目标板的位移,从而建立输出电压与施加扭矩之间的对应关系。传感器带宽和分辨率与微飞行器飞行实验的标准相匹配,同时对离轴负载保持不敏感。经实验测定,该单轴扭矩传感器的带宽为1.1kHz,测量范围为±260.8μNm,分辨率为0.013μNm,可以满足微飞行器扭矩的测量需求。     

NOVEL BIPHASE CODE——INTEGRATED SIDELOBE SUPPRESSION CODE

A kind of novel binary phase code named sidelobe suppression code is proposed in this paper.It is defined to be the code whose corresponding optimal sidelobe suppression filter outputs the minimum sidelobes.It is shown that there do exist sidelobe suppression codes better than the conventional optimal codes-Barker codes.For example,the sidelobe suppression code of length 11 with filter of length 39 has better sidelobe level up to 17dB than that of Barker code with the same code length and filter length.     

多晶硅薄膜压阻系数的理论研究

利用应力退耦模型,分别对多晶硅薄膜晶粒中性区和晶界势垒区的压阻系数进行了理论分析,并推导出多晶硅压阻系数的表达式.实验结果表明,利用文中推导出的理论公式所获得的计算值与实验测量结果基本符合,所给出的有关多晶硅压阻系数的理论结果可以作为多晶硅特性分析的理论依据.     

推进剂初始温度影响液体火箭发动机燃烧稳定性的数值模型

对自然推进剂（ＭＭＨ／ＮＴＯ）初始温度对火箭发动机燃烧稳定性的影响进行了研究,从推进剂初始温度对蒸发速率的影响规律出发,发展了初始温度大小影响蒸发速率的物理模型。燃烧流动过程应用圆柱坐标系下的两相湍流化学反应Ｎａｖｉｅｒ－Ｓｔｏｋｅｓ方程来描述,控制方程是用限体积法在任意曲线坐标系下进行离散,计算采用ＴＭＭ方法生成的正交网格。完善了一种压力隐式算子分裂算法,使之应用到燃烧过程和不稳定燃烧中,提高了计算的精度和稳定性;以蒸发作为燃烧速率控制过程,由ＭＭＨ的分解蒸发速率来控制。用蒸发和分解的时滞来分析燃烧不稳定性。应用ＣＦＤ技术发展了评定燃烧稳定性的脉冲枪模型,之后对推进剂初始温度对燃烧稳定性的影响进行了数值研究,得到其对振荡的敏感分析,并给出燃烧稳定性的极限图,说明了该物理模型和算法的可靠性。     

Temporal and 2-D small-signal gain measurements in a supersonicCOIL

A dedicated CW chemical oxygen iodine mini-laser is constructed and used to probe the two-dimensional (2-D) distribution of small-signal gains in a supersonic CW chemical oxygen iodine laser (CW COIL). The uneven lateral gain distribution may possibly be explained by boundary layer effects     

添加Y2O3的自蔓延高温合成β-Sialon粉的微波烧结

采纳合理的保温结构，利用TE103单模腔微波烧结系统对添加6wt％Y2O3的自蔓延高温合成β-Sialon粉末的微波烧结行为、烧结样品的微观结构和力学性能进行了研究，SEM和TEM、HREM观察表明，烧结样品晶粒细小，微观结构均匀，力学性能测试表明在1600℃保温5min时烧结样品具有抗弯强度为470MPa，断裂韧性为5．0MPa·m－2，洛氏硬度为89．5；在1650℃保温5min时烧结样品具有抗弯强度为630MPa，断裂韧性为5．8MPa·m-2，洛氏硬度为91．6．