Peptide mimics, possessing excellent biocompatibility and protease stability, have attracted broad attention and research in the biomedical field. β-Peptides and β-peptoids, as two types of vital peptide mimics, have demonstrated great potential in the field of foldamers, antimicrobials and protein binding, etc. Currently, the main synthetic strategies for β-peptides and β-peptoids include solid-phase synthesis and polymerization. Among them, polymerization in one-pot can minimize the repeated separation and purification used in solid-phase synthesis, and has the advantages of high efficiency and low cost, and can synthesize β-peptides and β-peptoids with high molecular weight. This review summarizes the polymerization methods for β-peptides and β-peptoids. Moreover, future developments of the polymerization method for the synthesis of β-peptides and β-peptoids will be discussed. 相似文献
产地与兰州百合(Lilium davidii var. unicolor)质量安全和营养品质密切相关,其溯源确证有利于实施产地保护、特色产品保真及产业可持续发展。本研究利用同位素比率质谱(Isotope ratio mass spectrometry,IRMS)和电感耦合等离子体质谱(Inductively coupled plasma mass spectrometry,ICP-MS)测定兰州百合4个主产区样品的δ13C、δ15N、δ18O等3种稳定同位素比率和K、Mg、Ca、Na、B、Fe、Zn、Al、Mn、Cu、Mo、Cr、Cd、Se、As、Pb等16种矿质元素含量,结合主成分分析(Principal component analysis,PCA)、正交偏最小二乘法判别分析(Orthogonal partial least squares discrimination analysis,OPLS-DA)和线性判别分析(Linear discriminant analysis,LDA)对不同产区兰州百合构建分类模型,验证判别溯源确证。结果显示:δ13C、δ15N、K、Mg、Na、B、Fe、Mn、Cu、Mo、Cr、Cd在产地间存在显著差异(P<0.05);PCA分析提取5个主成分,累计方差贡献率84.36%;LDA原始判别正确率100%,留一法交叉验证(Leave-one-out cross validation,LOO-CV)判别正确率为88.89%;OPLS-DA模型正确判别率为100%,分类效果最佳。本研究表明,基于兰州百合稳定同位素和矿质元素含量构建的多元统计分类模型可有效区分不同产区兰州百合,促进其追溯制度的建立和完善,对兰州百合的产地保护与质量控制具有重要意义。 相似文献
Protection of Metals and Physical Chemistry of Surfaces - Mg and its alloys are considered as biodegradable metallic implant materials, are attracting great attentions. However, the corrosion... 相似文献
To analyze the vibration response of a rotor system with circumferential short spring dual mass flywheel (DMF) when the primary flywheel speed changes, the interactions (forces and torques) between the primary flywheel, spring seat, spring, and secondary flywheel are analyzed in detail, and the dynamic analysis model of the DMF rotor system is established considering the influence of clearance and friction between parts in the DMF in this study. The vibration response of the DMF is investigated by numerical method. By analyzing the bifurcation diagram, time history, phase trajectories, Poincaré section, and frequency domain of the relative angular displacement, the variation of vibration form of the system under different excitation frequencies are discussed. Besides, the effects of load, primary flywheel speed amplitude, and spring stiffness on system vibration are also analyzed. Finally, some of the results from the analytical study are verified through the DMF rotor system experiments.