The density of truth in monadic fragments of some intermediate logics

This paper is an attempt to count the proportion of tautologies of some intermediate logics among all formulas. Our interest concentrates especially on Medvedev’s logic and its fragment over language with one propositional variable.     

Effects of Front-End Planning under Fast-Tracked Project Delivery Systems for Industrial Projects

Front-end planning (FEP) may be a key element in project success because it helps project participants more efficiently mitigate risk and define project objectives in the preplanning phase. However, very little is known about the effect of FEP for industrial project performance under different project delivery systems. To this end, this study investigated the impact of FEP on project performance by focusing on two widely used fast-track delivery methods: design-build (DB) and construction manager at risk (CMR), compared to the benchmarking conventional design-bid-build (DBB). The Spearman’s correlation analysis and Kruskal-Wallis test were performed on a real-world dataset, obtained from the Construction Industry Institute (CII), which comprised 438 industrial projects built between 1990 and 2010 in the US. The correlation analysis results revealed that better FEP resource allocation could help more design packages be completed efficiently and accurately to accelerate the fast-track process. The pair-wise comparison analysis results confirmed that there is no significant evidence to examine particular difference of schedule performance between CMR and DB. On the other hand, the results highlighted that project cost performance under DB were better than CMR. The results and findings of this study will help decision-makers choose appropriate project delivery methods for given project priorities.     

Pathophysiology of the Different Clinical Phenotypes of Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common form of autoimmune polyneuropathy. It is a chronic disease and may be monophasic, progressive or recurrent with exacerbations and incomplete remissions, causing accumulating disability. In recent years, there has been rapid progress in understanding the background of CIDP, which allowed us to distinguish specific phenotypes of this disease. This in turn allowed us to better understand the mechanism of response or non-response to various forms of therapy. On the basis of a review of the relevant literature, the authors present the current state of knowledge concerning the pathophysiology of the different clinical phenotypes of CIDP as well as ongoing research in this field, with reference to key points of immune-mediated processes involved in the background of CIDP.     

Zur Nitrierung von 2-Methylaminopyridin-N-oxid-Derivaten

Nitration of Some Derivatives of 2-Methylaminopyridine N-Oxides The only stable products obtained from nitrations of 2-methylaminopyridine N-oxide and some derivatives, are those resulting from nitration of the pyridine ring. Thus, 2-methyl-aminopyridine N-oxide 8 is nitrated under mild conditions to yield 2-methylamino-5-nitropyridine N-oxide 9 , but not 2-methylnitraminopyridine-N-oxide 10 is obtained. 2-Methylamino-4-nitropyridine N-oxide 1 yields 2-methylamino-4,5-dinitropyridine N-oxide 2 upon nitration. Chemical reactions which relate known compounds to the new compounds obtained, confirm the assigned structures.     

N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia

Treatment of negative symptoms and cognitive disorders in patients with schizophrenia is still a serious clinical problem. The aim of our study was to compare the efficacy of chronic administration of the atypical antipsychotic drug aripiprazole (7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl] butoxy}-3,4-dihydro-2(1H)-quinolinone; ARI) and the well-known antioxidant N-acetylcysteine (NAC) both in alleviating schizophrenia-like social and cognitive deficits and in reducing the decreases in the levels of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex (PFC) and hippocampus (HIP) of adult Sprague-Dawley rats, that have been induced by chronic administration of the model compound L-buthionine-(S, R)-sulfoximine (BSO) during the early postnatal development (p5–p16). ARI was administered at doses of 0.1 and 0.3 mg/kg while NAC at doses of 10 and 30 mg/kg, alone or in combination. Administration of higher doses of ARI or NAC alone, or co-treatment with lower, ineffective doses of these drugs significantly improved social and cognitive performance as assessed in behavioral tests. Both doses of NAC and 0.3 mg/kg of ARI increased the expression of BDNF mRNA in the PFC, while all doses of these drugs and their combinations enhanced the levels of BDNF protein in this brain structure. In the HIP, only 0,3 mg/kg ARI increased the levels of both BDNF mRNA and its protein. These data show that in the rat BSO-induced neurodevelopmental model of schizophrenia, ARI and NAC differently modulated BDNF levels in the PFC and HIP.     

The Effect of the BCO2 Genotype on the Expression of Genes Related to Carotenoid,Retinol, and α-Tocopherol Metabolism in Rabbits Fed a Diet with Aztec Marigold Flower Extract

This study investigated the effect of the BCO2 genotype and the addition of Aztec marigold flower extract to rabbit diets on the expression of BCO1, BCO2, LRAT, and TTPA genes in the liver. The levels of lutein, zeaxanthin, β-carotene, retinol, and α-tocopherol in the liver and blood serum of rabbits, as well as plasma biochemical parameters and serum antioxidant enzyme activities were also determined. Sixty male Termond White growing rabbits were divided into three groups based on their genotype at codon 248 of the BCO2 gene (ins/ins, ins/del and del/del); each group was divided into two subgroups: one subgroup received a standard diet, and the other subgroup was fed a diet supplemented with 6 g/kg of marigold flower extract. The obtained results indicate that the BCO2 genotype may affect the expression levels of BCO1 and BCO2 genes in rabbits. Moreover, the addition of marigold extract to the diet of BCO2 del/del rabbits may increase the expression level of the BCO2 gene. Finally, an increase in the amount of lutein in the diet of rabbits with the BCO2 del/del genotype contributes to its increased accumulation in the liver and blood of animals without compromising their health status or liver function.     

Novel Short PEG Chain-Substituted Porphyrins: Synthesis,Photochemistry, and In Vitro Photodynamic Activity against Cancer Cells

This work presents the synthesis and characterization of metal-free, zinc (II), and cobalt (II) porphyrins substituted with short PEG chains. The synthesized compounds were characterized by UV-Vis, ¹H and ¹³C NMR spectroscopy, and MALDI-TOF mass spectrometry. The origin of the absorption bands for tested compounds in the UV-Vis range was determined using a computational model based on the electron density functional theory (DFT) and its time-dependent variant (TD-DFT). The photosensitizing activity was evaluated by measuring the ability to generate singlet oxygen (ΦΔ), which reached values up to 0.54. The photodynamic activity was tested using bladder (5637), prostate (LNCaP), and melanoma (A375) cancer cell lines. In vitro experiments clearly showed the structure–activity relationship regarding types of substituents, their positions in the phenyl ring, and the variety of central metal ions on the porphyrin core. Notably, the metal-free derivative 3 and its zinc derivative 6 exerted strong cytotoxic activity toward 5637 cells, with IC₅₀ values of 8 and 15 nM, respectively. None of the tested compounds induced a cytotoxic effect without irradiation. In conclusion, these results highlight the potential value of the tested compounds for PDT application.     

Assessment of Cosmetic and Dermatological Properties and Safety of Use of Model Skin Tonics with Kombucha-Fermented Red Berry Extracts

Kombucha is a health-promoting beverage that is produced by fermenting sweetened tea using symbiotic cultures of bacteria belonging to the genus Acetobacter, Gluconobacter, and yeast of the genus Saccharomyces. This study compared the cosmetic and dermatological properties of the extracts of the following redberries: R. rubrum, F. vesca, and R. idaeus, and their ferments, which were obtained by fermentation for 10 and 20 days using tea fungus. For this purpose, the fermented and non-fermented extracts were compared in terms of their chemical composition using the HPLC/ESI-MS chromatographic method, demonstrating the high content of biologically active compounds that were present in the ferments. The antioxidant activity of the tested samples was evaluated using DPPH and ABTS tests, as well as by evaluating the scavenging of the external and intracellular free radicals. The cytotoxicity of the extracts and the ferments, as well as the cosmetic formulations, were also determined by conducting Alamar Blue and Neutral Red tests assessing the cell viability and metabolism using skin cell lines: fibroblasts and keratinocytes. In addition, application tests were conducted showing the positive effects of the model cosmetic tonics on the TEWL, the skin hydration, and the skin pH. The results indicate that both the extracts and the ferments that were obtained from kombucha can be valuable ingredients in cosmetic products.     

Optimization of Multilayer Films Composed of Chitosan and Low-Methoxy Amidated Pectin as Multifunctional Biomaterials for Drug Delivery

Polyelectrolyte multilayers (PEMs) based on polyelectrolyte complex (PEC) structures are recognized as interesting materials for manufacturing functionalized coatings or drug delivery platforms. Difficulties in homogeneous PEC system development generated the idea of chitosan (CS)/low-methoxy amidated pectin (LM PC) multilayer film optimization with regard to the selected variables: the polymer ratio, PC type, and order of polymer mixing. Films were formulated by solvent casting method and then tested to characterize CS/LM PC PECs, using thermal analysis, Fourier transform infrared spectroscopy (FTIR), turbidity, and zeta potential measurements. The internal structure of the films was visualized by using scanning electron microscopy. Analysis of the mechanical and swelling properties enabled us to select the most promising formulations with high uniformity and mechanical strength. Films with confirmed multilayer architecture were indicated as a promising material for the multifunctional systems development for buccal drug delivery. They were also characterized by improved thermal stability as compared to the single polymers and their physical mixtures, most probably as a result of the CS–LM PC interactions. This also might indicate the potential protective effect on the active substances being incorporated in the PEC-based films.     

Densification of Ni and TiAl by SPS: Kinetics and Microscopic Mechanisms

Densification by spark plasma sintering (SPS) of ductile (Ni) and brittle (TiAl) metallic materials has been studied to elucidate the mechanism of densification in the two cases. Isothermal densification experiments were carried out to determine the activation parameters in Ni. Transmission electron microscopy (TEM) observations of thin foils extracted by focused ion beam (FIB) in the contact regions between particles of TiAl and Ni powders are presented. Macroscopically, the most striking feature observed here is that the densification of Ni takes place in the wide temperature range of 0.2 to 1.0 T_m, whereas that of TiAl varies in the temperature range of 0.7 to 0.9 T_m, which is significantly narrower (T_m being the melting temperature of Ni and the peritectic temperature of TiAl). In Ni, the low activation energy (164 ± 30 kJ/mol), the high dislocation density in the interparticle contact region, and the formation of recovery cells involving dislocation climb indicate that the rate-controlling mechanism is probably self-diffusion in dislocations. In TiAl, high dislocation densities leading to reorganization into subboundaries point to dislocation climb mechanisms, which are kinetically controlled by volume diffusion. The difference in densification kinetics between Ni and TiAl is then accounted for in terms of the difference in their respective rate-controlling mechanisms operative during densification.