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71.
EJ Velthuis-te Wierik H van den Berg JA Weststrate KH van het Hof C de Graaf 《Canadian Metallurgical Quarterly》1996,50(4):214-219
Plasma levels of fibrinogen, factor VIIc and prothrombin fragment F1 + 2, a marker of thrombin generation in vivo, were studied in 68 subjects with serum total cholesterol (TC) levels between 135 and 349 mg/dl but without clinical evidence of cardiovascular disease and other atherosclerotic risk factors. F1 + 2 plasma levels were directly correlated with TC (p < 0.0004), low-density lipoprotein cholesterol (LDL-C; p < 0.0018) and factor VIIc (p < 0.024). Thirty-five subjects with TC greater than 249 mg/dl (median value of the whole group) showed higher levels of F1 + 2 (p < 0.0001) and fibrinogen (p < 0.0015) than those with TC lower than 249 mg/dl. In subjects with TC > 249 mg/dl and F1 + 2 > 1.2 nM (median value of the whole group), a cholesterol-lowering drug (simvastatin) was able to reduce F1 + 2 (p < 0.009) as well as TC and LDL-C. This study shows a relationship between serum cholesterol and the rate of thrombin generation supporting the hypothesis that a hypercoagulable state may occur in hypercholesterolemic subjects before the onset of clinical evidence of atherosclerotic cardiovascular disease. 相似文献
72.
JH Viles JB Mitchell SL Gough PM Doyle CJ Harris PJ Sadler JM Thornton 《Canadian Metallurgical Quarterly》1996,242(2):352-362
The aqueous solution structure of the cyclic pentapeptide cyclo(-Ser-D-Leu-Asp-Val-Pro-) has been determined by two-dimensional 1H-NMR spectroscopy, combined with a conformational search and distance-geometry calculations. As many as five conformers in slow exchange were observed, and the rate of interconversion between components was measured from the build-up rates of exchange peaks. NMR data allowed the structures of the two predominant conformers to be determined. The major component (66%) contained a cis-proline as part of a type-VIa2 beta-turn encompassing residues Asp-Val-cis-Pro-Ser. The second component (16%) contained only trans-amide bonds, and a type-VIII beta-turn formed by residues Val-Pro-Ser-D-Leu. These structures are discussed in relation to the (phi, psi), space available to the cyclic pentapeptide, determined by a conformational search, and in relation to previously published cyclic-pentapeptide structures. The molecule exhibits activity in a scintillation-proximity assay for the inhibition of the interaction between the integrin very-late antigen-4 (VLA-4; alpha 4 beta 1) and vascular-cell-adhesion molecule-1 (VCAM-1). The structure/activity relationship of the LDV sequence is discussed and related to the recently published X-ray structure of VCAM-1. The relevance of the work to the design of anti-inflammatory drugs is discussed. 相似文献
73.
Cristiane Vieira Helm Alicia de Francisco Salete Aparecida Gaziola Ricardo Francisco Fornazier Georgia Bertoni Pompeu Ricardo Antunes Azevedo 《Food Biotechnology》2005,18(3):327-341
Barley (Hordeum vulgare L.) has had an important impact on human nutrition. Hull-less barley is a genetically improved type that has been widely used in recent years. Six Brazilian hull-less barley varieties (IAC-IBON 214-82; IAC 8612-421; IAC 8501-31; IAC 8501-12; IAPAR 39-ACUMAI; IAC 8501-22) were analyzed for storage protein constituents, amino acid contents, and similarity among the hull-less barley varieties. Albumins, globulins, prolamins I and II, and glutelins were extracted and separated by SDS-PAGE. The total protein amino acid contents of the flour were also determined for each variety by TLC and HPLC. Variations in intensity and appearance and disappearance of protein bands were observed among the varieties suggesting genetic variability. However, the amino acid profile did not indicate any major variations in the amino acid concentrations. The high lysine and threonine total concentrations detected in the seeds of the hull-less barley varieties encouraged an investigation into the regulation of amino acid metabolism and storage protein synthesis. 相似文献
74.
We describe a method for computing solutions of multi-point boundary value problems, where the polychotomic structure of the underlying solution space is specifically exploited. After the system is integrated in a multiple shooting way, the resulting linear system is solved by a special decoupling algorithm that takes into account the fact that the dichotomy on each interval is potentially different (in contrast to the two point case). A number of examples sustains the theory. 相似文献
75.
Jing Wang Walker D.M. Xiang Lu Majhi A. Kruseman B. Gronthoud G. Villagra L.E. van de Wiel P.J.A. Eichenberger S. 《Design & Test of Computers, IEEE》2007,24(3):226-234
Excessive power supply noise during test can cause overkill. This article discusses two models for supply noise in delay testing and their application to test compaction. The proposed noise models avoid complicated power network analysis, making them much faster than existing power noise analysis tools. can cause performance degradation and 相似文献
76.
Hemagglutinins present in Amaranthus leucocarpus seed meal were extracted with saline buffer and nutritive value was estimated by PER, NPR as well as Digestible Energy Consumption Evaluations. Protein digestibility was determined both in vitro and in vivo. Trypsin inhibitor activity was also determined. Saline-extracted Amaranth meal had significantly higher PER and NPR values than whole meal (p<0.05). There were no significant differences in digestible energy (Kcal/day/ animal) and protein consumption (g/day/animal) between diets (p<0.05). A. leucocarpus improves in nutritive value after the saline extraction procedures and has a good potential as a complementary food due to its lysine content. In addition purified agglutinin may be a useful biochemical. 相似文献
77.
Transport problems typically involve at least two types of constraints, on income and on time. Therefore, the indirect utility
function depends either on the income available after having subtracted the cost of the discrete alternative and on the free
time left after having worked and travelled by each competing option. In the typical linear-in-the-attributes and in-the-parameters
specification, that represents the first grade approximation of the indirect utility function, the effect of income and time
constraints cancel out and only the cost and time of the alternatives matter in the comparison between them. From a microeconomic
point of view this is equivalent to assume that income and time effects could be disregarded; which is not always the case.
To account for these effects the utility function should include second order attributes; however, in non-linear utility functions
it may not be easy to distinguish among several effects that could be relevant: direct preferences for good and leisure, and
simple interactions between attributes other than income and time effects. This paper analyses these effects from a theoretical
point of view focusing on the possible confounding problem in detecting income and time effects. We use a dataset collected
for a modal choice context and containing both revealed and stated preference data, and estimate several NL models examining
the effect of the different second-order terms on detecting income and time effects. We compared specifications including
square cost and time attributes, interactions between time and cost, cost divided by the income available to be spent on free
time, and time multiplied by free time. Our results confirm the strong effect of direct preferences for goods and leisure
time on choice, and the potential confounding effect between quadratic attributes and other non-linear omitted terms. Finally,
we also found that care should be taken in highlighting income and time effects using mixed data sources, since confounding
effects can occur when non-linearities are accounted for in both data sets. 相似文献
78.
79.
80.
Russomanno D.J. de Jongh Curry A.L. Atanasova G.S. Hunt L.C. Goodwin J.C. 《IEEE transactions on information technology in biomedicine》2008,12(1):76-86
DefibViz is a software application developed for defibrillation simulation and visualization. It exploits both surface techniques and methods for the interactive exploration of volumetric datasets for the analysis of transthoracic defibrillation simulation results. DefibViz has a graphical user interface for the specification of the shape, size, position, and applied voltage of a defibrillator's electrodes. An option is provided for using 3D slice plane widgets, which operate on the volumetric datasets, such that the distribution of the voltage gradient induced by an electric shock can be visually inspected in various tissues throughout the myocardium and torso. One goal of DefibViz is to enhance understanding of how electrode parameters relate to the change of the voltage gradient distribution throughout the heart, which may help lead to optimal defibrillator design. DefibViz is significant, in that, it is built by using an open-source graphics and visualization framework providing a platform for subsequent modifiability and extensibility. Moreover, it integrates simulation and visualization techniques, which previously required the running of several independent software executables, into an enhanced, seamless, and comprehensive software application. 相似文献