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151.
152.
M P Vaquero M Veldhuizen W van Dokkum C J A van den Hamer G Schaafsma 《Journal of the science of food and agriculture》1994,64(4):475-481
The influence of drinking tea on copper bioavailability is unclear, particularly when tea is consumed with food. A breakfast meal containing white bread, margarine, strawberry jam, cheese and tea, with or without milk, was digested in; vitro and the dialysis of copper investigated. Reference breakfasts were prepared with water and water with milk. Copper dialysability (percentage of copper dialysed) was markedly increased by tea. The influence of adding milk to tea was not significant. A second study was carried out in rats using the breakfasts containing tea and water. They were spiked with 64Cu and given orally to the animals in a single dose. Whole-body 64Cu retention was measured over a 4-day period after administration. In order to determine the true absorption of 64Cu a control group of rats received the dose intraperitioneally. The results in vivo indicate a tendency to higher absorption and retention of 64Cu with tea. Liver 64Cu retention was significantly elevated by tea. Therefore, the presence of tea in a breakfast meal favours the formation of soluble low-molecular-weight ligands which can be absorbed and retained by rats. The concomitant increase in liver copper retetition may be associated with higher bioavailability and/or lower copper mobilisation. 相似文献
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155.
van Leeuwen Lieselotte; Smitsman Ad; van Leeuwen Cees 《Canadian Metallurgical Quarterly》1994,20(1):174
Perceiving the affordance of a tool requires the integration of several complementary relationships among actor, tool, and target. Higher order affordance structures are introduced to deal with these forms of complex action from an ecological-realist point of view. The complexity of the higher order affordance structure was used to predict the difficulty of perceiving the tool function. Predictions were tested in 3 experiments involving children between 9 mo and 4 yrs old. In a classical tool use task dating back to W. K?hler (1921), a desirable target was obtained by using a hook as a tool. The relative positions of the hook and the target were systematically varied to obtain structures differing in complexity. The observed difficulty of the task was found essentially in accordance with the theoretical complexity of the higher order affordance structures involved in perceiving the tool function. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
156.
YT van der Schouw WA van den Beld GA van der Sanden RA Binkhorst FJ Gabre?ls AL Verbeek 《Canadian Metallurgical Quarterly》1993,35(7):608-613
The authors conducted an assessment study of newly developed motor performance items for the diagnosis of myopathy. 17 children who had had muscle biopsy for this diagnosis in the recent past were administered 14 items based on the measurement of static, dynamic and explosive muscle strength and muscle endurance. Individual items did not have perfect discriminative power, but the results were encouraging enough to warrant detailed study with combinations of the items, so that in future fewer children will have to undergo unnecessary muscle biopsies. 相似文献
157.
J Jassem H Karnicka-M?odkowska C van Pottelsberghe M van Glabbeke MA Noseda A Ardizzoni F Gozzelino A Planting N van Zandwijk 《Canadian Metallurgical Quarterly》1993,(12):1720-1722
26 previously treated patients with progressive recurrent small cell lung cancer (SCLC) were given vinorelbine (Navelbine), 30 mg/m2 weekly. All patients had responded to first-line chemotherapy and were off therapy for at least 3 months. Partial response was observed in 4 out of 25 eligible patients (16%; 95% confidence interval 4-36%), stable disease in 7 patients and progression in 12 patients. The limiting toxicity was a non-cumulative leucopenia (80%, 32% WHO grade 3-4). Reaction at the site of injection was observed in 5 patients, causing treatment discontinuation in 2 cases. Other non-haematological toxicities were moderate. These results suggest acceptable toxicity and some antitumour activity of vinorelbine in pretreated SCLC patients. 相似文献
158.
R.N. KieftC.C.M. Rindt A.A. van Steenhoven 《International Journal of Heat and Mass Transfer》2002,45(13):2739-2753
A combined numerical and experimental investigation is presented showing the effect of heat on the stability of a horizontal vortex street for ReD=75 and RiD between 1 and 2. Detailed 2D-HiRes PV experiments are compared with 2D numerical results. The results show that an early transition to 3D of the vortex street takes place for RiD>1. Furthermore, the location at which the 2D wake becomes essentially 3D turns out to be dependent on RiD. For an increasing addition of heat (increasing RiD), this location is shifted into the direction of the cylinder. By applying 3D measuring techniques, such as 3D-PTV and 3D visualisation techniques, the transition process and the behaviour downstream of the transition point are investigated. 相似文献
159.
S Petrasch LJ van Tits HJ Motulsky OE Brodde MC Michel 《Canadian Metallurgical Quarterly》1993,43(8):904-908
The effects of the antiasthmatic drug ketotifen (CAS 34580-13-7) on human mononuclear leukocytes were studied in vitro and in vivo. In vitro ketotifen concentration-dependently inhibited mitogen-stimulated lymphocyte proliferation. High ketotifen concentrations also inhibited T-lymphocyte mitogen- and adenosine triphosphate stimulated increases in intracellular Ca2+ in lymphocytes and the U937 human monocyte precursor cell line, respectively; this involved inhibition of both Ca2+ influx and intracellular mobilization. In in vivo experiments, treatment of healthy volunteers with 1 mg ketotifen b.i.d. for 7 d did not alter the number or subset composition of circulating lymphocytes. Moreover, the mitogen-stimulated in vitro proliferation of lymphocytes obtained before and after ketotifen treatment in vivo was similar. It is concluded that high ketotifen concentrations can inhibit the activation of resting lymphocytes in vitro but standard ketotifen treatment does not notably affect the number of function of circulating lymphocytes in vivo. 相似文献
160.
EM de Jong BA Seegers MK Gulinck JB Boezeman PC van de Kerkhof 《Canadian Metallurgical Quarterly》1996,193(4):300-303
We present the first case of esophagogastric devascularization and esophagogastric transection using a stapler through laparoscopic surgery. The procedure was performed in a 71-year-old diabetic woman with alcoholic liver cirrhosis (Child-Pugh B class), portal hypertension, bleeding grade III esophageal varices, and a previous bleeding episode. The surgical technique was carried out without problems, and the patient had an excellent postoperative condition. Esophagogastric devascularization with esophageal transection using a stapler through laparoscopic surgery is a feasible technique that accomplishes the same and all objectives of the open procedure. Operative time in both methods is the same, whereas surgical trauma, inmunologic depletion, amount of transfused blood, pain, use of analgesics, and hospital stay are reduced in the laparoscopic technique. 相似文献