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排序方式: 共有406条查询结果,搜索用时 15 毫秒
31.
Annalisa Marcuzzi Elisa Piscianz Marina Zweyer Roberta Bortul Claudia Loganes Martina Girardelli Gabriele Baj Lorenzo Monasta Claudio Celeghini 《International journal of molecular sciences》2016,17(3)
Deregulation of the cholesterol pathway is an anomaly observed in human diseases, many of which have in common neurological involvement and unknown pathogenesis. In this study we have used Mevalonate Kinase Deficiency (MKD) as a disease-model in order to investigate the link between the deregulation of the mevalonate pathway and the consequent neurodegeneration. The blocking of the mevalonate pathway in a neuronal cell line (Daoy), using statins or mevalonate, induced an increase in the expression of the inflammasome gene (NLRP3) and programmed cell death related to mitochondrial dysfunction. The morphology of the mitochondria changed, clearly showing the damage induced by oxidative stress and the decreased membrane potential associated with the alterations of the mitochondrial function. The co-administration of geranylgeraniol (GGOH) reduced the inflammatory marker and the damage of the mitochondria, maintaining its shape and components. Our data allow us to speculate about the mechanism by which isoprenoids are able to rescue the inflammatory marker in neuronal cells, independently from the block of the mevalonate pathway, and about the fact that cell death is mitochondria-related. 相似文献
32.
33.
Valentina Medri Francesca Servadei Riccardo Bendoni Annalisa Natali Murri Angelo Vaccari Elena Landi 《Journal of the European Ceramic Society》2019,39(7):2453-2462
Cold Sintering Process (CSP) was applied on commercial nanopowders to produce nanostructured TiO2 anatase with nano-to-macro porosity. Nanoporous TiO2 based materials were obtained by applying CSP at 150 °C and pressures up to 500 MPa on three TiO2 nanopowders with different specific surface area (s.s.a. = 50, 90 and 370 m2/g), using water as transient aqueous environment. Although TiO2 is insoluble in water, a density of 68% and s.s.a. = 117 m2/g were achieved from the powder with the highest specific surface area. A post annealing process at 500 °C increased the density up to 73% with a s.s.a. = 59 m2/g, and the crystallites dimensions passed from 110 Å in the powder to 130 Å in CSP material and 172 Å after post annealing. Finally, macroporosity was produced by using thermoplastic polymer beads as sacrificial templates within TiO2 nanopowder during CSP, followed by a debonding at 500 °C. 相似文献
34.
This paper presents the results of a study on the electrokinetic treatment of kaolinite and humic acid kaolinite complexes spiked with 2,6-dichlorophenol or 3-(3,4-dichlorophenyl)-1,1-dimethylurea (diuron). In particular, the attention was paid to the interaction between solid surface and dissolved organics: the effects of contaminant sorption as well as the physicochemical reactions on the efficiency of electrokinetic remediation were investigated. Using a 3V/cm voltage gradient, approximately 90% of diuron was removed from kaolinite after one water pore volume was collected in the cathode reservoir, but much lower efficiency was obtained in the electrokinetic removal of this compound from humic acid-coated kaolinite. The results also showed that partial degradation of the contaminant occurred during electrokinetic treatment of kaolinite clay spiked with 2,6-dichlorophenol: the contamination in the clay could be remediated by the combination of electrokinetic extraction and electrochemical reactions. 相似文献
35.
Terenzio Bertuzzi Silvia Rastelli Annalisa Mulazzi Gianluca Donadini Amedeo Pietri 《Food Control》2011,22(12):2059-2064
The occurrence of ochratoxin A, trichothecenes, fumonisins and aflatoxins in a sample of 106 beers produced in several European countries, was investigated. The analyses were conducted using high-performance liquid chromatography with fluorimetric detection for ochratoxin A and aflatoxins, gas-chromatography and high-performance liquid chromatography, both coupled with mass spectrometer, for trichothecenes and fumonisins, respectively. Aflatoxins were not detected in any samples, whereas ochratoxin A, deoxynivalenol and fumonisins were found in a relatively high number of samples. Their presence was at low levels in all samples; however, some differences were observed between the European countries. As regards ochratoxin A, beer samples from southern Europe showed levels always lower than 0.040 μg l?1, while the samples from other European countries showed significantly higher values, up to 0.189 μg l?1 (P < 0.001). For fumonisins, the levels of Italian beers were significantly higher compared to the samples from other countries (P = 0.006). 相似文献
36.
Novella Bartolini Tiziana Calamoneri Emanuele Guido Fusco Annalisa Massini Simone Silvestri 《Wireless Networks》2010,16(3):607-625
Mobile sensor networks are important for several strategic applications devoted to monitoring critical areas. In such hostile
scenarios, sensors cannot be deployed manually and are either sent from a safe location or dropped from an aircraft. Mobile
devices permit a dynamic deployment reconfiguration that improves the coverage in terms of completeness and uniformity. In
this paper we propose a distributed algorithm for the autonomous deployment of mobile sensors called Push & Pull. According
to our proposal, movement decisions are made by each sensor on the basis of locally available information and do not require
any prior knowledge of the operating conditions or any manual tuning of key parameters. We formally prove that, when a sufficient
number of sensors are available, our approach guarantees a complete and uniform coverage. Furthermore, we demonstrate that
the algorithm execution always terminates preventing movement oscillations. Numerous simulations show that our algorithm reaches
a complete coverage within reasonable time with moderate energy consumption, even when the target area has irregular shapes.
Performance comparisons between Push & Pull and one of the most acknowledged algorithms show how the former one can efficiently
reach a more uniform and complete coverage under a wide range of working scenarios. 相似文献
37.
Giulia Bernardini Maurizio Comanducci Stefania Bambini Giovanni Renzone Andrea Scaloni Giovanna Morelli Mark Achtman Giulio Ratti Annalisa Santucci 《Proteomics. Clinical applications》2009,3(10):1251-1254
We previously described the first reference map for the proteome of one strain of serogroup A Neisseria meningitidis (MenA), a major cause of epidemic meningitis in humans. As a preliminary finding, in that work we noted that 2‐DE protein maps of closely related MenA isolates from different epidemics spreads could be easily compared to detect minor differences and that 2‐DE phenotypes attributable to the well‐known epidemiological marker tbpB agreed with the genoclouds model of MenA epidemiological variation during pandemic waves. We explored here the possibility that an extended comparative study of 2‐DE maps of isolates representative of the nine genoclouds described by Achtman and collaborators could be used to discriminate between strains otherwise undistinguishable. We showed the example of 14 proteins with different 2‐DE spot patterns in different genoclouds that could be considered as putative tracers for alike‐strains discrimination. We introduce the novel concept that comparative proteomics can be useful in identifying new epidemiological markers for N. meningitidis. 相似文献
38.
Different strategies for modelling and reducing the effect of uncertainties on the dynamic behaviour of coupled structures are discussed in this paper. In assembled structures, each component satisfies specifications about material properties and dimensional tolerances. Variability of design specifications within the tolerance field may affect the dynamic behaviour of the assembled structure more than that of any individual component substructure. Among modelling strategies, non-predictive techniques such as post-processing of data from a set of randomly assembled structures and analysis of sensitivities to uncertain variables are considered. However, emphasis is placed on a less trivial yet simple strategy such as the use of design of experiments to fit a regression model. Different reduction strategies are considered according to whether small design changes (even revised tolerance allocation) are still possible or not. In the latter case, selective assembly is extended to problems where the performance requirement is not the clearance between two parts, but a prescribed dynamic behaviour. 相似文献
39.
Polyphasic characterization of indigenous lactobacilli and lactococci from PDO Canestrato Pugliese cheese 总被引:1,自引:0,他引:1
Lucia Aquilanti Emanuele Zannini Annalisa Zocchetti Andrea Osimani Francesca Clementi 《LWT》2007,40(7):1146-1155
A polyphasic approach, involving both genotypic and phenotypic analyses was used to characterize 33 isolates of lactic acid bacteria from the raw milk Protected Designation of Origin (PDO) Canestrato Pugliese cheese, in order to select candidate strains that can be used as autochthonous starter cultures in the dairy industry. Randomly amplified polymorphic DNA (RAPD) analysis and clustering by the unweighted pair-group method with arithmetic averages (UPGMA) were used to evaluate the genotypic diversity, while phenotypic characterization was performed through miniaturized assays and traditional biochemical tests. Technological properties of major interest for cheese-making (acidification, tendency to lysis, proteolytic and peptidase activity) were also evaluated, and selected subset of data was statistically examined by the one-way ANOVA and the Tukey-Kramer HSD test, to highlight strain-specific and species-specific differences among the isolates. A high degree of diversity appeared in the phenotypic and technological traits in opposition to a relatively low genotypic diversity. Although none of the isolates showed the best performances in all the activities, an appropriate mixture of strains could be selected for providing an efficacious autochthonous starter culture. 相似文献
40.
D. D. B. Van Bragt W. J. M. De Kruijf A. Manera T. H. J. J. Van Der Hagen H. Van Dam 《Nuclear Engineering and Design》2002,215(1-2)
A dynamic model for natural circulation boiling water reactors (BWRs) under low-pressure conditions is developed. The motivation for this theoretical research is the concern about the stability of natural circulation BWRs during the low-pressure reactor start-up phase. There is experimental and theoretical evidence for the occurrence of void flashing in the unheated riser under these conditions. This flashing effect is included in the differential (homogeneous equilibrium) equations for two-phase flow. The differential equations were integrated over axial two-phase nodes, to derive a nodal time-domain model. The dynamic behavior of the interface between the one and two-phase regions is approximated with a linearized model. All model equations are presented in a dimensionless form. As an example the stability characteristics of the Dutch Dodewaard reactor at low pressure are determined. 相似文献