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排序方式: 共有354条查询结果,搜索用时 78 毫秒
151.
I. Antcheva M. Ballintijn B. Bellenot M. Biskup R. Brun N. Buncic Ph. Canal D. Casadei O. Couet V. Fine L. Franco G. Ganis A. Gheata D. Gonzalez Maline M. Goto J. Iwaszkiewicz A. Kreshuk D. Marcos Segura R. Maunder L. Moneta A. Naumann E. Offermann V. Onuchin S. Panacek F. Rademakers P. Russo M. Tadel 《Computer Physics Communications》2009,180(12):2499-2512
152.
The permeation characteristics and the selectivity of four nitrile rubber films with respect to 1,3-butadiene and isobutene were studied as a function of experimental conditions and the nature of membrane material. A specific research apparatus was developed, allowing the determination of both permeation rate and selectivity, at a temperature varying between 0° and 30°C and under a pressure of from 1 to 3 bars. The inverse proportion of permeation rate to membrane thickness was verified for a thickness of from 12 to 500 microns. An increase in temperature promotes liquid permeation and is detrimental to gas permeation, the latter being facilitated by an increase in pressure. The introduction of an inert gas pressure on the liquid did not bring about an increase in the liquid permeation rate. The permeation rate decreases as a result of an increase in the proportion of acrylonitrile in the rubber, which also affects selectivity; the latter reaches a maximum value when said proportion is about 23%. The effect of the composition of the feed mixture was also studied and curves were determined relating, simultaneously, selectivity and permeation rate to the 1,3-butadiene content. Selectivity is maximal with mixtures having a very high 1,3-butadiene content. The solubilities of 1,3-butadiene and of isobutene in the four types of nitrile rubber were measured at 0°C and at 20°C (68°F). Selectivity can be interpreted in terms of the solubilities of the two hydrocarbons. 相似文献
153.
154.
Agustina Bouchet Juan I. Pastore Marcel Brun Virginia L. Ballarin 《Signal, Image and Video Processing》2017,11(6):1065-1072
In this paper, we propose the use of compensatory fuzzy logic to extend mathematical morphology (MM) operators to gray-level images, in a similar way than fuzzy logic is used, naming it compensatory fuzzy mathematical morphology (CFMM). We study the compliance with the four principles of quantification and analyze the robustness of these operators by comparing them with Classic MM and fuzzy mathematical morphology (FMM), in the context of the processing of magnetic resonance images under noisy conditions. We observed that operators of CFMM are more robust, relative to noise, than MM and FMM ones, for the type of images used. As an additional result of this work, we developed a library for CFMM operators, plus an additional graphical user interface, which brings together the new operators with a wide range of operators of FMM and Classic MM. 相似文献
155.
Paola Brun Annj Zamuner Chiara Battocchio Leonardo Cassari Martina Todesco Valerio Graziani Giovanna Iucci Martina Marsotto Luca Tortora Valeria Secchi Monica Dettin 《International journal of molecular sciences》2021,22(11)
Hybrid biomaterials allow for the improvement of the biological properties of materials and have been successfully used for implantology in medical applications. The covalent and selective functionalization of materials with bioactive peptides provides favorable results in tissue engineering by supporting cell attachment to the biomaterial through biochemical cues and interaction with membrane receptors. Since the functionalization with bioactive peptides may alter the chemical and physical properties of the biomaterials, in this study we characterized the biological responses of differently functionalized chitosan analogs. Chitosan analogs were produced through the reaction of GRGDSPK (RGD) or FRHRNRKGY (HVP) sequences, both carrying an aldehyde-terminal group, to chitosan. The bio-functionalized polysaccharides, pure or “diluted” with chitosan, were chemically characterized in depth and evaluated for their antimicrobial activities and biocompatibility toward human primary osteoblast cells. The results obtained indicate that the bio-functionalization of chitosan increases human-osteoblast adhesion (p < 0.005) and proliferation (p < 0.005) as compared with chitosan. Overall, the 1:1 mixture of HVP functionalized-chitosan:chitosan is the best compromise between preserving the antibacterial properties of the material and supporting osteoblast differentiation and calcium deposition (p < 0.005 vs. RGD). In conclusion, our results reported that a selected concentration of HVP supported the biomimetic potential of functionalized chitosan better than RGD and preserved the antibacterial properties of chitosan. 相似文献
156.
157.
The dual of an entanglement-assisted quantum error-correcting (EAQEC) code is the code resulting from exchanging the original code’s information qubits with its ebits. To introduce this notion, we show how entanglement-assisted repetition codes and accumulator codes are dual to each other, much like their classical counterparts, and we give an explicit, general quantum shift-register circuit that encodes both classes of codes. We later show that our constructions are optimal, and this result completes our understanding of these dual classes of codes. We also establish the Gilbert–Varshamov bound and the Plotkin bound for EAQEC codes, and we use these to examine the existence of some EAQEC codes. Finally, we provide upper bounds on the block error probability when transmitting maximal-entanglement EAQEC codes over the depolarizing channel, and we derive variations of the hashing bound for EAQEC codes, which is a lower bound on the maximum rate at which reliable communication over Pauli channels is possible with the use of pre-shared entanglement. 相似文献
158.
Conclusion An increase in the ultimate breaking strength, stress-rupture strength, and fatigue limit of alloy VT3-1 with a lamellar structure may be achieved as a result of refining any parameter of the structure, particularly -phase platelet thickness, and increasing the volume fraction of secondary -phase. An increase in ductility characteristics, toughness, and creep resistance may be provided by increasing the dimensions of -colonies and primary -phase particles (up to 2.5–3.5 m) and reducing the volume fraction and dispersivity of secondary -phase lamellar precipitates. Coarsening of -grains leads to an increase in ac, kQ, and refinement leads to an increase in and an.Qualitative dependences for mechanical properties of alloy VT3-1 on lamellar structure parameters made it possible to isolate those structural parameters which have the most marked effect on properties.The properties of alloys with a finely lamellar structure (d25 m, bI, II<2 m) are most sensitive to structure. In this case a change in -colony size by 10 m and -platelet thickness by 1 m affects the properties 3–20 times more strongly than a change in -grain size by 100 m. The effect of finely dispersed secondary -phase precipitates is greater, the coarser the primary -phase structure. Refinement of primary -phase structure with an increase in secondary phase platelet thickness to 1 m or more reduces the sensitivity of alloy mechanical properties to the effect of secondary -phase.With coarsening of the intragranular structure (d>25 m, bI, II2 m) the effect of structural parameters d and b on properties is markedly weakened: on strength properties (f,
100
450
) by a factor of 100, on ductility (, ), by a factor of 10 to 20, and on impact strength and fracture toughness (an, ac, KQ) by a factor of five.The qualitative relationships obtained between structure and mechanical properties of alloy VT3-1 are fundamental for controlling the structure of semifinished titanium alloy products.Translated from Metallovedenie i Termicheskaya Obrabotka Metallov, No. 7, pp. 52–55, July, 1986. 相似文献
159.
Discovery and Characterization of ACT‐451840: an Antimalarial Drug with a Novel Mechanism of Action
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Dr. Christoph Boss Dr. Hamed Aissaoui Nathalie Amaral Aude Bauer Stephanie Bazire Dr. Christoph Binkert Prof. Reto Brun Dr. Cédric Bürki Dr. Claire‐Lise Ciana Dr. Olivier Corminboeuf Stephane Delahaye Claire Dollinger Christoph Fischli Dr. Walter Fischli Alexandre Flock Dr. Marie‐Céline Frantz Malory Girault Dr. Corinna Grisostomi Astrid Friedli Dr. Bibia Heidmann Claire Hinder Gael Jacob Amelie Le Bihan Sophie Malrieu Dr. Saskia Mamzed Aurelien Merot Dr. Solange Meyer Dr. Sabrina Peixoto Nolwenn Petit Dr. Romain Siegrist Julien Trollux Dr. Thomas Weller Dr. Sergio Wittlin 《ChemMedChem》2016,11(18):1995-2014
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub‐Saharan Africa, Central and South America, and Asia. Resistance to standard therapy, including artemisinin combinations, is increasing. There is an urgent need for novel antimalarials with new mechanisms of action. In a phenotypic screen, we identified a series of phenylalanine‐based compounds that exhibit antimalarial activity via a new and yet unknown mechanism of action. Our optimization efforts culminated in the selection of ACT‐451840 [(S,E)‐N‐(4‐(4‐acetylpiperazin‐1‐yl)benzyl)‐3‐(4‐(tert‐butyl)phenyl)‐N‐(1‐(4‐(4‐cyanobenzyl)piperazin‐1‐yl)‐1‐oxo‐3‐phenylpropan‐2‐yl)acrylamide] for clinical development. Herein we describe our optimization efforts from the screening hit to the potential drug candidate with respect to antiparasitic activity, drug metabolism and pharmacokinetics (DMPK) properties, and in vivo pharmacological efficacy. 相似文献
160.
A method is presented for the automated extraction of myocardial borders in M-mode echocardiograms. The successive steps of processing are: preprocessing for noise reduction, enhancement of border characteristics using a set of suitably chosen matched filters, and final extraction of border points by searching for optimal paths along the time axis. During the last step of processing, the contribution of each elementary border element is characterised by a normalized correlation coefficient. The optimal path, defined as the one that maximizes the sum of all elementary contributions, is determined efficiently using dynamic programming. An alternative approach uses a maximum tracking procedure whose performances are improved by utilizing a local model to predict the position of the next border point. Experimental examples are presented and the performance of both border extraction algorithms are compared. 相似文献