Experiences with large-scale operational trials of ALTO-enhanced P2P filesharing in an intra-ISP scenario

Application Layer Traffic Optimization (ALTO) has recently gained attention in the research and standardisation community as a way for a network operator to guide the peer selection process of distributed applications by providing network layer topology information. In particular P2P applications are expected to gain from ALTO, due to the many connections peers form among each other, often without taking network layer topology information into account. In this paper, we present results of an extensive intra-ISP trial with an ALTO-enhanced P2P filesharing software. In summary, our results show that—depending on the concrete setting and on the distribution of upload capacity in the network—ALTO enables an ISP to save operational costs significantly while not degrading application layer performance noticeably. In addition, based on our experience we are able to give advice to operators on how to save costs with ALTO while not sacrificing application layer performance at all.     

Empirical research in on-line trust: a review and critical assessment

Lack of trust is one of the most frequently cited reasons for consumers not purchasing from Internet vendors. During the last four years a number of empirical studies have investigated the role of trust in the specific context of e-commerce, focusing on different aspects of this multi-dimensional construct. However, empirical research in this area is beset by conflicting conceptualizations of the trust construct, inadequate understanding of the relationships between trust, its antecedents and consequents, and the frequent use of trust scales that are neither theoretically derived nor rigorously validated. The major objective of this paper is to provide an integrative review of the empirical literature on trust in e-commerce in order to allow cumulative analysis of results. The interpretation and comparison of different empirical studies on on-line trust first requires conceptual clarification. A set of trust constructs is proposed that reflects both institutional phenomena (system trust) and personal and interpersonal forms of trust (dispositional trust, trusting beliefs, trusting intentions and trust-related behaviours), thus facilitating a multi-level and multi-dimensional analysis of research problems related to trust in e-commerce.     

Thymic alterations in feline GM1 gangliosidosis

GM1 gangliosidosis is an inherited metabolic disease characterized by progressive neurological deterioration with premature death seen in children and numerous animals, including cats. We have observed that thymuses from affected cats greater than seven months of age (GM1 mutant cats) show marked thymic reduction compared to age-matched normal cats. The studies reported here were done to describe alterations in the thymus prior to (less then 90 days of age) and during the development of mild (90 to 210 days of age) to severe (greater than 210 days of age) progressive neurologic disease and to explore the pathogenesis of the thymic abnormality. Although histologic examination of the thymus from GM1 affected cats less than 210 days of age showed no significant differences from age-matched control cats, thymuses from GM1 mutant cats greater than 210 days of age were significantly reduced in size (approximately 3-fold). Histologic sections of lymph nodes, adrenal glands, and spleens from GM1 gangliosidosis-affected cats showed no significant differences. Flow cytometric analyses showed a marked decrease in the percentage of immature CD4+CD8+ thymocytes (p < 0.001) and significantly increased CD4-CD8+ cells (p < 0.01) in GM1 mutant cats greater than 210 days of age when compared to normal age matched cats. Co-labelling with CD4, CD8, and CD5 indicated an increase in the percentage of GM1 mutant cat thymocytes at this age which were CD5high, suggesting the presence of more mature cells. Cytometric analyses of subpopulations of peripheral lymphocytes indicated an increase in CD4-CD8+ cells (p < 0.05) with concurrent decreases in CD4+CD8- and CD4-CD8- cells (which were not significant). Similar analyses of thymocyte and lymphocyte subpopulations from cats < 210 days of age showed no significant differences between GM1 mutant and normal cells. GM1 mutant cats at all ages had increased surface binding of Cholera toxin B on thymocytes, indicating increased surface GM1 ganglioside expression. Increases were highly significant in GM1 mutant cats greater than 210 days of age. In situ labelling for apoptosis was increased in GM1 mutant cats between 90 to 200 days of age when thymic masses were within normal limits. In GM1 mutant cats over 200 days of age, decreased labelling was observed when thymic mass was reduced and the CD4+CD8+ subpopulation, known to be very susceptible to apoptosis, was significantly decreased. These data describe premature thymic involution in feline GM1 gangliosidosis and suggest that increased surface GM1 gangliosides alters thymocyte development in these cats.     

Linkage analysis between manic-depressive illness and markers on the long arm of chromosome 11

The effect of two cyclic enkephalin analogs (IVS-43 and IVS-46) on the group and individual behavior of rhesus macaques and hamadryas baboons has been studied. A pronounced influence of IVS-46 on competitive and operant goal-directed behavior of the monkeys was identified.     

Sampling designs for stereology*

The purpose of this paper is to propose the necessary sampling techniques for estimating a global parameter defined in a solid opaque specimen (e.g. the total volume of mitochondria in a given liver, the total capillary surface area in a given lung, etc.). The geometry of the specimen often suggests a multi-level or cascade sampling design at different magnifications, whereby the object phase at one level becomes the reference phase in the next level. The final parameter is then estimated as the product of the intermediate ratios with the volume of the specimen, which is estimated independently. Each level can be regarded as an independent sampling design; a given stereological project may be planned in terms of one or more of these designs. Our development is a blend of practical experience and recent theoretical advances on sampling for stereology with well-known sampling techniques previously developed with different purposes in mind.     

Industrielle Anwendung von zeolithischen Katalysatoren beim Hydrocracken

Industrial application of zeolitic catalysts in hydrocracking . For maximum production of gasoline by hydrocracking using zeolite type catalysts two cracking schemes are presented and the operation conditions, feedstocks, yields, and material balances are discussed. The advantages of zeolitic hydrocracking catalysts are outlined. The main catalyst parameters controlling activity and selectivity are described and a scheme for the preparation of zeolitic catalysts is given, which illustrates the superiority of zeolitic hydrocracking catalysts over amorphous ones. Finally, the hydrocracking of residues is reviewed and a typical process together with the product characteristics and yields obtained is described.     

Wechselbeziehungen zwischen Physikalischer und Technischer Chemie

Interactions between physical and industrial chemistry. The most important interactions for the two areas of chemistry are found in the following three fields: (1)states of materials (states of aggregation) and thermodynamics; (2) kinetics of molecular processes as a basis for macroscopic models; (3) methods of testing and measurement and development of equipment. The ?classical state”? of each of these areas is first sketched out and then the principal developments which are still in course of flux; directions of future development are then deduced. Such directions are exposed to be: extension of the scope of application of supercritical states as solvents and reaction media, as part of a general expansion of industrial application of elevated pressures; increase in knowledge of nonlinear dynamics of chemical systems with regard to transient behaviour and control mechanisms; increase in basic research on molecular structure and dynamics at the interfaces of dispersed systems – especially micelles and catalyst surface – using ?in situ”? methods, and more extensive utilization of the results in industrial chemistry.     

Exact 3-satisfiability is decidable in time O(20.16254n)

Let F = C ₁ C _m be a Boolean formula in conjunctive normal form over a set V of n propositional variables, s.t. each clause C _i contains at most three literals l over V. Solving the problem exact 3-satisfiability (X3SAT) for F means to decide whether there is a truth assignment setting exactly one literal in each clause of F to true (1). As is well known X3SAT is NP-complete [6]. By exploiting a perfect matching reduction we prove that X3SAT is deterministically decidable in time O(2^0.18674n ). Thereby we improve a result in [2,3] stating X3SAT O(2^0.2072n ) and a bound of O(2^0.200002n ) for the corresponding enumeration problem #X3SAT stated in a preprint [1]. After that by a more involved deterministic case analysis we are able to show that X3SAT O(2^0.16254n ).An extended abstract of this paper was presented at the Fifth International Symposium on the Theory and Applications of Satisfiability Testing (SAT 2002).