TRPV4 Promotes Metastasis in Melanoma by Regulating Cell Motility through Cytoskeletal Rearrangement

The abnormal expression of Transient Receptor Potential cation channel subfamily V member 4 (TRPV4) is closely related to the progression of multiple tumors. In addition, TRPV4 is increasingly being considered a potential target for cancer therapy, especially in tumor metastasis prevention. However, the biological correlation between TRPV4 and tumor metastasis, as well as the specific role of TRPV4 in malignant melanoma metastasis, is poorly understood. In this study, we aimed to examine the role of TRPV4 in melanoma metastasis through experiments and clinical data analysis, and the underlying anticancer mechanism of Baicalin, a natural compound, and its inhibitory effect on TRPV4 with in vivo and in vitro experiments. Our findings suggested that TRPV4 promotes metastasis in melanoma by regulating cell motility via rearranging the cytoskeletal, and Baicalin can inhibit cancer metastasis, whose mechanisms reverse the recruitment of activated cofilin to leading-edge protrusion and the increasing phosphorylation level of cortactin, which is provoked by TRPV4 activation.     

分流制雨水管网滞留污染物的估算研究

为了定量研究降雨时分流制雨水管网滞留污染物占总污染物的比例,对某研究区域雨水管网中的滞留污染物定期取样检测,并根据研究区域的基础数据建立SWMM模型。同时,提出了一种雨水管网滞留污染物的计算方法,即以检测到的雨水管网污染物浓度及充满度计算滞留污染物质量。将滞留污染物数据输入SWMM模型中,分析对比有无滞留污染物的管网排放口污染物浓度的变化情况。模拟结果表明,在1年一遇的降雨条件下,雨水系统内的滞留污染物对COD、NH3-N、TP总污染负荷的贡献率分别为43. 30%、92. 75%、58. 83%,雨水管网滞留污染物占雨水管网总污染物的比例较大。     

构筑精神的家园——谈社区重建中的户外窒闻设计

通过阐述社区重建中户外空间需要具有精神内涵的重要性、必要性,分析灾后社区居民精神需求的特点,该文呼吁震后社区重建活动要关注社区精神,关注居民精神生活,最后提出了灾后社区重建的应注意的问题,旨在为地震区的居民创造出真正宜居的社区和宜居的城市.     

Highly Stretchable and Sensitive Flexible Strain Sensor Based on Fe NWs/Graphene/PEDOT:PSS with a Porous Structure

With the rapid development of wearable smart electronic products, high-performance wearable flexible strain sensors are urgently needed. In this paper, a flexible strain sensor device with Fe NWs/Graphene/PEDOT:PSS material added under a porous structure was designed and prepared. The effects of adding different sensing materials and a different number of dips with PEDOT:PSS on the device performance were investigated. The experiments show that the flexible strain sensor obtained by using Fe NWs, graphene, and PEDOT:PSS composite is dipped in polyurethane foam once and vacuum dried in turn with a local linearity of 98.8%, and the device was stable up to 3500 times at 80% strain. The high linearity and good stability are based on the three-dimensional network structure of polyurethane foam, combined with the excellent electrical conductivity of Fe NWs, the bridging and passivation effects of graphene, and the stabilization effect of PEDOT:PSS, which force the graphene-coated Fe NWs to adhere to the porous skeleton under the action of PEDOT:PSS to form a stable three-dimensional conductive network. Flexible strain sensor devices can be applied to smart robots and other fields and show broad application prospects in intelligent wearable devices.     

法国贝尔纳尔丹铀矿床热液蚀变与成矿特征研究

在总结法国贝尔纳尔丹花岗岩型铀矿床蚀变类型、矿物组合、矿物生成顺序等矿化特征基础上,对矿床的蚀变特征和成矿模式进行了探讨。该矿床含矿围岩分别为英云闪长岩-花岗闪长岩(G型)和中-粗粒过铝质二云母浅色花岗岩(L型),其中L型花岗岩为含矿围岩。矿床中与铀矿化密切相关的蚀变类型较多,最典型的当属由富18 O流体进入花岗岩裂隙形成的变正长岩化蚀变,使花岗岩更为碎裂,增加了成矿空间并在之后的流体作用下发生再次蚀变,形成伊利石-蒙脱石并吸附了铀石,伊利石化-蒙脱石化越强烈,铀矿化程度越高。铀矿化是两次蚀变的产物,矿体的形态不仅受变正长岩中形成的裂隙构造所控制,同时矿化还受流经变正长岩的流体和表生作用的控制。     

Geometric Mean Maximum FSVMI Model and Its Application in Carotid Artery Stenosis Risk Prediction

Carotid artery stenosis is a serious medical condition that can lead to stroke.Using machine learning method to construct classifier model,carotid artery stenos...     

Effects of Oxygen Concentration in Monocrystalline Silicon on Reverse Leakage Current of PIN Rectifier Diodes

The effects of initial oxygen concentration on the reverse leakage current of PIN rectifier diodes were studied.We fabricated the PIN rectifier diodes with different initial oxygen concentrations,and analyzed the electrical properties,anisotropic preferred etching by means of optical microscopy,Fourier transform infrared spectroscopy and transmission electron microscopy.It is pointed out that the reverse leakage current increases exponentially with the increasing initial oxygen concentration.Fur...     

煤矿避难硐室热环境控制范围探讨

基于国内外矿井避难硐室环境控制技术的研究现状,比较了国内外关于避难硐室环境控制条款规定,探讨了环境控制参数的允许范围,并从建设成本及人员安全角度出发,分析了目前针对避难硐室空气品质控制技术和温度控制技术的不足,指出了未来避难硐室环境控制技术的研究方向：①制订合理的环境参数允许范围;②基于矿井压风的CO浓度多种控制技术的协同作用;③CO₂被动化学吸附技术;④多重复合控温技术。

     

苹果疏除幼果与成熟果多糖成分分析及抗氧化活性研究

为了探究苹果疏除幼果与成熟果多糖组成成分及抗氧化活性的的差异,采用热水浸提法从苹果幼果与成熟果果渣中分别提取多糖,通过PMP柱前衍生化高效液相色谱法（HPLC）分析两种多糖的单糖组成,并通过体外抗氧化评价体系对二者的抗氧化活性进行比较研究。结果表明:苹果疏除幼果与成熟果多糖均由10种单糖构成,但单糖比例存在较大差异,抗氧化结果表明:苹果疏除幼果与成熟果多糖均具有一定的还原能力,并对O-2·、DPPH·和·OH具有清除能力,但在相同浓度水平下,苹果疏除幼果多糖的抗氧化能力显著高于成熟果多糖。      

响应面法优化泡椒牦牛黄喉制作工艺研究

对牦牛黄喉进行泡椒产品的开发,有利于牦牛副产物的增值增效,提高产品附加值。本实验以水煮时间、食用碱质量浓度、浸渍液中泡椒的比例和泡制时间4个反应因素,以泡椒牦牛黄喉感官评分为评价指标,在单因素工艺实验的基础上,通过四因素三水平的Box-Behnken响应面分析法优化泡椒牦牛黄喉的制作工艺条件。经方差分析得知泡制时间和食用碱质量浓度的交互影响显著,泡椒比例和泡制时间对泡椒牦牛黄喉的交互影响极显著。结果表明,最优制作条件为水煮时间25min,食用碱质量浓度0.7g/100m L,泡椒比例21%,泡制时间53h。在此制作条件下得到泡椒牦牛黄喉色泽良好,口感细腻,脆嫩,泡椒香气浓郁,泡椒牦牛黄喉感官评分可达到36.19。验证实验泡椒牦牛黄喉感官评分为35.27,表明实验结果与软件优化结果相符。