A new circuit topology for continuous group delay synthesis

A new circuit topology is realized in order to synthesize group delay continuously. The circuit is based upon a new variable coupling coefficient coupled line section and a microstrip feedback loop. The new variable coupler is designed by periodically loading an edge coupled microstrip coupler. With this new design, coupling variation of more than 10 dB may be achieved. To the best of the authors knowledge, this is the first report of this type of microstrip coupler. The complete circuit consumes no do power and exhibits more than 500 ps of continuous variable true time delay. Insertion loss is better than 3 dB and return loss is better than 15 dB     

Metamaterial-based electronically controlled transmission-line structure as a novel leaky-wave antenna with tunable radiation angle and beamwidth

A metamaterial-based electronically controlled transmission-line structure is presented and demonstrated as a novel leaky-wave (LW) antenna with tunable radiation angle and beamwidth functionalities. This structure is in essence a composite right/left-handed (CRLH) microstrip structure incorporating varactor diodes for fixed-frequency voltage-controlled operation. Angle scanning at a fixed frequency is achieved by modulating the capacitances of the structure by adjusting the (uniform) bias voltage applied to the varactors. Beamwidth tuning is obtained by making the structure nonuniform by application of a nonuniform bias voltage distribution of the varactors. A rigorous analysis based on an extension of the CRLH concept is proposed and the corresponding dispersion curves, obtained by equivalent-circuit formulas with LC parameters extracted from full-wave simulation, are shown. A 30-cell LW antenna structure, incorporating both series and shunt varactors for optimal impedance matching and maximal tuning range, is designed. This prototype exhibits continuous scanning capability from 50/spl deg/ to -49/spl deg/ by tuning the bias voltages from 0 to 21 V at 3.33 GHz. A maximum gain of 18 dBi at broadside is also achieved. In addition, it provides half-power beamwidth variation of up to 200% with comparison to the case of uniform biasing. The effect of intermodulation due to the nonlinearity of the varactors is shown to be negligible for antenna applications. The antenna is tested in a 10-Mb/s binary phase-shift key transmission link and successful recovery of the baseband data is demonstrated.     

Phenomenological loss equivalence method for planar quasi-TEMtransmission lines with a thin normal conductor or superconductor

The incremental inductance rule for conductor loss calculations is not valid if conductor thickness decreases and becomes comparable to the penetration depth. A simple approach, referred to as the phenomenological loss equivalence method is proposed for characterizing a planar quasi-TEM transmission line with a thin normal conductor or superconductor over a wide range of field penetrations. For microstrip lines with a thin copper or high-T_c superconductor, the conductor losses calculated by this method agree very well with the published data calculated by the finite-element method and the Monte Carlo method, respectively. Because of the simplicity of the calculation, the method should be very useful for the computer-aided design of monolithic microwave circuits     

New nibbled-page architecture for high-density DRAMs

A nibbled-page architecture which can be used to access all column addresses on the selected row address randomly in units of 8 bits at the 100 Mbit/s data rate is discussed. To realize such high-speed architecture, three key circuit techniques have been developed. An on-chip interleaved circuit has been used for the high-speed serial READ and WRITE operations. Column address prefetch and WE signal prefetch techniques have been introduced to eliminate idle time between 8 bit units. The nibbled-page architecture has been successfully implemented in an experimental 16 Mb DRAM, and 100 Mb/s operation has been achieved. The DRAM with nibbled-page mode is very effective in simplifying the design of high-speed data transfer systems     

Properties of Bi-doped PbTe layers grown by liquid phase epitaxy under controlled Te vapor pressure

Effects of Bi doping in PbTe liquid-phase epitaxial layers grown by the temperature difference method under controlled vapor pressure (TDM-CVP) are investigated. For Bi concentrations in the solution, x_Bi, lower than 0.2 at.%, an excess deep-donor level (activation energy E_d≈0.03–0.04 eV) appears, and Hall mobility is low. In contrast, for x_Bi>0.2 at.%, Hall mobility becomes very high, while carrier concentration is in the range of 10¹⁷ cm⁻³. Inductive coupled plasma (ICP) emission analysis shows that, for x_Bi=1 at.%, Bi concentration in the epitaxial layer is as high as N_Bi=2.3–2.7 × 10¹⁹ cm⁻³. These results indicate that Bi behaves not only as a donor but also as an acceptor, and the nearest neighbor or very near donor-acceptor (D-A) pairs are formed, so that strong self-compensation of Bi takes place. Carrier concentration for highly Bi-doped layers shows a minimum at a Te vapor pressure of 2.2 × 10⁻⁵ torr for growth temperature 470°C, which is coincident with that of the undoped PbTe.     

Occurrence of introns in the 16S rRNA genes of members of the genus Thermoproteus

Cervical smears (n = 150) from five departments showing high-grade dyskaryosis were examined by three cytologists. All the smears came from patients with biopsy-proven CIN III. One hundred had been correctly reported (true positives) but 50 had originally been reported as negative and had been found to be positive only on review (false negatives). There were significant differences between the two sets in the characteristics of the dyskaryotic cell population. The false-negative smears tended to have fewer than 200 dyskaryotic cells. The nuclei of the dyskaryotic cells tended to have fine rather than coarse nuclear chromatin. A smear with fewer than 50 dyskaryotic cells is 26 times more likely to be reported as negative than one with more than 200 dyskaryotic cells. The results suggest that there is a type of severely dyskaryotic smear that is inherently likely to be missed on routine screening.     

Cytotoxicity induced by Erythrina variegata serine proteinase inhibitors in tumor hematopoietic stem cell lines

A prospective study of activated protein C sensitivity, protein C, protein S, and other coagulation factors in 239 women during normal pregnancy was carried out. Protein C activity appeared unaffected by gestation, although an elevation of protein C activity was observed in the early puerperium. A fall in total and free protein S with increasing gestation was observed. Activated protein C sensitivity ratio (APC:SR) showed a progressive fall through pregnancy. This fall correlated with changes in factor VIIIc, factor Vc and protein S. 38% of subjects, with no evidence of Factor V Leiden or anticardiolipin antibodies, showed a low APC:SR (APC:SR <2.6) in the third trimester of pregnancy. Aside from a significant reduction in birth weight, no difference in pregnancy outcome was observed between these subjects and those with a normal APC:SR. Activated protein C sensitivity ratio, modified by pre-dilution of patient samples with factor V depleted plasma, showed no consistent trend with gestation.     

3D-spiral CT of multiple exostoses

We report pre- and post-operative three-dimensional (3D)-spiral CT images in a patient with multiple exostoses. Images of 3D-CT, which were performed using the integrated 3D software of the CT system, showed the exact shapes and locations of the individual tumors around the knee joint in comparison with the surgical findings and resected specimen. 3D-spiral CT images of multiple exostoses would be useful for the planning of surgical procedure.     

Pathway for Ca2+ influx into cells by trichosporin-B-VIa, an alpha-aminoisobutyric acid-containing peptide, from the fungus Trichoderma polysporum

Trichosporin (TS) -B-VIa, a fungal alpha-aminoisobutyric acid (Aib) -containing peptide consisting of 19 amino acid residues and a phenylalaninol, produced both 45Ca2+ influx into bovine adrenal chromaffin cells and catecholamine secretion from the cells. The secretion induced by TS-B-VIa at lower concentrations (2-5 microM) was completely dependent on the external Ca2+, while that induced by TS-B-VIa at higher concentrations (10-30 microM) was partly independent of the Ca2+. The concentration-response curves (2-5 microM) for the TS-B-VIa-induced Ca2+ influx and secretion correlated well. The TS-B-VIa (at 5 microM) -induced secretion was not antagonized by diltiazem, a blocker of L-type voltage-sensitive Ca2+ channels. The treatment of fura-2-loaded C6 glioma cells with TS-B-VIa (2-5 microM) led to an increase in the intracellular free Ca2+ concentration ([Ca2+]i) in a concentration-dependent manner but the stimulatory effects of TS-B-VIa on [Ca2+]i were only slightly observed in Ca(2+)-free medium, indicating that TS-B-VIa causes Ca2+ influx from the external medium into the C6 cells. The TS-B-VIa-induced increase in [Ca2+]i in the C6 cells was not antagonized by diltiazem and by SK&F 96365, a novel blocker of receptor-mediated Ca2+ entry. High K+ increased neither [Ca2+]1 in the C6 cells nor Mn2+ influx into the cells, while TS-B-VIa increased Mn2+ influx. Also in other non-excitable cells, bovine platelets, similar results were obtained. These results strongly suggest that the mechanism of Ca2+ influx by TS-B-VIa at the lower concentrations is distinct from the event of Ca2+ influx through receptor-operated or L-type voltage-sensitive Ca2+ channels in both excitable cells (the chrornaffin cells) and non-excitable cells (the C6 cells and the platelets) and that TS-B-VIa per se may form Ca(2+)-permeable ion channels in biological membranes. On the other hand, the peptide at the higher concentrations seems to damage cell membranes.     

Arterial ketone body ratio and its modification by PGE1 in elderly patients during gastrectomy

Breeding studies are reported of a previously undescribed hereditary retinal degeneration identified in the Siberian Husky breed of dog. This disorder clinically resembles the previously reported autosomal recessive canine hereditary retinal degenerations collectively termed progressive retinal atrophy (PRA). However, the pedigree of the propositus, a male Siberian Husky, exhibited an X-linked pattern of transmission. This dog was outcrossed to three phenotypically normal female laboratory Beagles and two of their F1 daughters were bred to a phenotypically normal male Beagle, producing affected males in the F2 generation. Subsequent inbreedings produced further affected males and affected females as well. X-linked transmission was established by exclusion of alternative modes of inheritance and, consequently, the disease has been termed X-linked progressive retinal atrophy (XLPRA). This is the first reported X-linked retinal degeneration in an animal. Because of the many similarities of PRA in dogs to retinitis pigmentosa (RP) in humans, this new disease may not only represent the first animal model of X-linked RP (XLRP) but may well be a true homolog of one of the XLRP loci (RP2, RP3, RP6). It is the first retinal degeneration in dogs that can be assigned to an identified canine chromosome, and the first for which linkage mapping offers a realistic approach to proceed by positional cloning towards identifying the responsible gene locus.