A ladder to human-comparable intelligence: an empirical metric

ABSTRACT

The field of Artificial General Intelligence needs a simple and understandable measure of progress to aid in passing the difficult Turing Test. The proposed Ladder Metric introduces a sequence of levels that intelligent agents must climb in order to reach the final, Turing indistinguishable, level. Just like the Turing test, the levels can only be defined in terms of general properties and behaviour rather than specific operational requirements. To track the progress and make comparisons one must climb and determine the achieved rung of the proposed ladder.     

Performance of the Fourier rebinning algorithm for PET with large acceptance angles

In order to assess the present situation of schistosomiasis in the Zona da Mata Sul, Pernambuco State, Brazil, a study was conducted in the following phases: origin, historical and temporal evolution, and basic determinants of this health/disease process; critical assessment of comprehensive intervention programs implemented by the State in the region since 1970; and a case study in 17 counties, representing 1,424 communities and 485,200 inhabitants, and Brazil's second most endemic region based on prevalence rates for schistosomiasis. Temporal series over a 14-year period were used to analyze results of intervention programs. Conclusions were: a) current positivity rates are higher than those observed in the early 1980s; b) the programs' strategy focused almost exclusively on mass treatment, thus allowing for reinfestation and occurrence of new cases; c) proposals such as the PCDEN (Program for Control of Endemic Diseases in the Northeast) aimed at decentralization to the municipal level in the 1990s were not effectively implemented, helping to leave this persistent endemic out of control.     

Algorithms and tools for the preprocessing of LC-MS metabolomics data

Metabolomics encompasses the study of small molecules in a biological sample. Liquid Chromatography coupled with Mass Spectrometry (LC-MS) profiling is an important approach for the identification and quantification of metabolites from complex biological samples. The amount and complexity of data produced in an LC-MS profiling experiment demand automatic tools for the preprocessing, analysis, and extraction of useful biological information. Data preprocessing—a topic that covers noise filtering, peak detection, deisotoping, alignment, identification, and normalization—is thus an active area of metabolomics research. Recent years have witnessed development of many software for data preprocessing, and still there is a need for further improvement of the data preprocessing pipeline. This review presents an overview of selected software tools for preprocessing LC-MS based metabolomics data and tries to provide future directions.     

Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry

Data processing and identification of unknown compounds in comprehensive two-dimensional gas chromatography combined with time-of-flight mass spectrometry (GC×GC/TOFMS) analysis is a major challenge, particularly when large sample sets are analyzed. Herein, we present a method for efficient treatment of large data sets produced by GC×GC/TOFMS implemented as a freely available open source software package, Guineu. To handle large data sets and to efficiently utilize all the features available in the vendor software (baseline correction, mass spectral deconvolution, peak picking, integration, library search, and signal-to-noise filtering), data preprocessed by instrument software are used as a starting point for further processing. Our software affords alignment of the data, normalization, data filtering, and utilization of retention indexes in the verification of identification as well as a novel tool for automated group-type identification of the compounds. Herein, different features of the software are studied in detail and the performance of the system is verified by the analysis of a large set of standard samples as well as of a large set of authentic biological samples, including the control samples. The quantitative features of our GC×GC/TOFMS methodology are also studied to further demonstrate the method performance and the experimental results confirm the reliability of the developed procedure. The methodology has already been successfully used for the analysis of several thousand samples in the field of metabolomics.     

The Influence of Modulated Slotted Synthetic Jet on the Bypass of Hump

This paper deals with the influence of phase modulated synthetic jet on the aerodynamics of the hump in a closed test section Of the Eiffel-type wind tunnel. Three experimental methods of measurement techniques of this phenomenon were used： the pressure profile using the Kiel total pressure probe, the velocity profile using the CTA （constant temperature anemometry） probe and the visualization of the flow field using the hot film and the thermo camera, The experimental results with and without the influence of the synthetic jet were compared, as well the impact of the phase shift of the neighbouring synthetic jets. As a reference case, the flow around the hump without the influence of the synthetic jet was selected. The results of the measurement are presented in figures and compared.     

Equivalent pulse parameters for electroporation

Electroporation-based applications require the use of specific pulse parameters for a successful outcome. When recommended values of pulse parameters cannot be set, similar outcomes can be obtained by using equivalent pulse parameters. We determined the relations between the amplitude and duration/number of pulses resulting in the same fraction of electroporated cells. Pulse duration was varied from 150 ns to 100 ms, and the number of pulses from 1 to 128. Fura 2-AM was used to determine electroporation of cells to Ca(2+). With longer pulses or higher number of pulses, lower amplitudes are needed for the same fraction of electroporated cells. The expression derived from the model of electroporation could describe the measured data on the whole interval of pulse durations. In a narrower range (0.1-100 ms), less complex, logarithmic or power functions could be used instead. The relation between amplitude and number of pulses could best be described with a power function or an exponential function. We show that relatively simple two-parameter power or logarithmic functions are useful when equivalent pulse parameters for electroporation are sought. Such mathematical relations between pulse parameters can be important in planning of electroporation-based treatments, such as electrochemotherapy and nonthermal irreversible electroporation.     

Point-in-polygon tests for geometric buffers

The point-in-polygon problem is often encountered in geographical information systems. The algorithms usually work on polygons defined by straight edges. In some situations, however, polygons containing circular arcs are applied. In geographical information systems these polygons are usually considered as geometric buffers, geodesic offsets, or geodesic parallels. This paper presents three algorithms suitable for providing information about the containment of a point in geometric buffers: the Ray-crossing method, the Cell-Based Algorithm and the Approximate approach. An extensive experimental section allows the reader to select the most efficient algorithm for practical problems.     

Iterative tomographic image reconstruction using Fourier-based forward and back-projectors

Iterative image reconstruction algorithms play an increasingly important role in modern tomographic systems, especially in emission tomography. With the fast increase of the sizes of the tomographic data, reduction of the computation demands of the reconstruction algorithms is of great importance. Fourier-based forward and back-projection methods have the potential to considerably reduce the computation time in iterative reconstruction. Additional substantial speed-up of those approaches can be obtained utilizing powerful and cheap off-the-shelf fast Fourier transform (FFT) processing hardware. The Fourier reconstruction approaches are based on the relationship between the Fourier transform of the image and Fourier transformation of the parallel-ray projections. The critical two steps are the estimations of the samples of the projection transform, on the central section through the origin of Fourier space, from the samples of the transform of the image, and vice versa for back-projection. Interpolation errors are a limitation of Fourier-based reconstruction methods. We have applied min-max optimized Kaiser-Bessel interpolation within the nonuniform FFT (NUFFT) framework and devised ways of incorporation of resolution models into the Fourier-based iterative approaches. Numerical and computer simulation results show that the min-max NUFFT approach provides substantially lower approximation errors in tomographic forward and back-projection than conventional interpolation methods. Our studies have further confirmed that Fourier-based projectors using the NUFFT approach provide accurate approximations to their space-based counterparts but with about ten times faster computation, and that they are viable candidates for fast iterative image reconstruction.     

Evaluation of Uncertainties Associated with Geocoding Techniques

Abstract:   Spatial databases contain geocoded data. Geocoded data play a major role in numerous engineering applications such as transportation and environmental studies where geospatial information systems (GIS) are used for spatial modeling and analysis as they contain spatial information (e.g., latitude and longitude) about objects. The information that a GIS produces is impacted by the quality of the geocoded data (e.g., coordinates) stored in its database. To make appropriate and reasonable decisions using geocoded data, it is important to understand the sources of uncertainty in geocoding. There are two major sources of uncertainty in geocoding, one related to the database that is used as a reference data set to geocode objects and one related to the interpolation technique used. Factors such as completeness, correctness, consistency, currency, and accuracy of the data in the reference database contribute to the uncertainty of the former whereas the specific logic and assumptions used in an interpolation technique contribute to the latter. The primary purpose of this article is to understand uncertainties associated with interpolation techniques used for geocoding. In doing so, three geocoding algorithms were used and tested and the results were compared with the data collected by the Global Positioning System (GPS). The result of the overall comparison indicated no significant differences between the three algorithms .     

X-ray residual stress measurement in metallic and ceramic plasma sprayed coatings

Processing-induced residual stresses play an important role in the production and performance of thermally sprayed coatings. Their precise determination is a key to influence the coating properties by modification of process variables and to understand the processing-structure-property relationship. Among various methods for residual stress measurement, x-ray diffraction holds a specific position as being non-destructive, phase distinctive, localized, and applicable for real parts. The sin² ω methods is commonly applied for bulk materials as well as coatings. However, the results are often reported without sufficient experimental details and the method is used in its simplified form without justification of certain assumptions. In this investigation, the sin² ω x-ray diffraction method was used to measure residual macrostress in plasma sprayed metallic (nickel, NiCrAlY, and molybdenum) and ceramic (ZrO₂ + 8% Y₂O₃) coatings. Reproducibility of the method was tested and the assumptions allowing its use are discussed and experimentally verified. For nickel coatings, a comparison with hole drilling and neutron diffraction measurements is presented. The influence of processing factors such as deposition temperature and coating thickness is studied and the results are discussed.