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51.
Role of primate medial vestibular nucleus in long-term adaptive plasticity of vestibuloocular reflex
1. Fifteen hundred and thirty cells were recorded in the medial vestibular nucleus (MVN) of alert monkeys whose vestibuloocular reflex (VOR) had been adapted to one of two kinds of spectacles. The "high-gain" sample was recorded from monkeys that had worn 2.0 x telescopic spectacles; the gain of the VOR in the dark (eye velocity divided by head velocity) was greater than 1.5. The "low-gain" sample was recorded from monkeys that had worn goggles providing a visual field that was fixed with respect to the freely turning head; the gain of the VOR was less than 0.4. 2. Cells showing modulation of firing rate related to imposed head velocity were grouped into four categories: pure vestibular (10), vestibular-plus-saccade (10), vestibular-plus-position (10), and vestibular-plus-head/body (24). Sensitivity to head velocity was measured from averaged responses to sinusoidal, 0.4-Hz whole-body oscillation in the horizontal plane. Almost all cells (98%) having increased firing during ipsilateral head rotation received inputs from the horizontal semicircular canals. Conversely, 82% of cells having increased firing during contralateral head rotation received inputs from the vertical canals. 3. There were no statistically significant differences in resting discharge rate, phase shift, or sensitivity to head velocity between the high- and low-gain samples of any of the cell types. Nonetheless, there was a consistent tendency, evident in all the functionally defined cell groups, for the sensitivity to be about 20% greater in the high-gain samples. However, this difference is small by comparison with the fourfold difference in VOR gain. 4. Detailed scrutiny of the response properties of individual cells suggested that the small differences in sensitivity reflect small changes distributed throughout the population, rather than large and potentially significant changes within a small sub-population. 5. Our data indicate that large, adaptive changes in the gain of the VOR are accompanied by only minor changes in the vestibular sensitivity and no changes in the phase shift or resting discharge rates of cells in the MVN. It remains possible that large changes in vestibular sensitivity occurred in cells we did not sample or in subgroups we could not identify. We argue that this is unlikely and that the major changes underlying VOR plasticity occur after the first central synapse in the VOR pathways. 相似文献
52.
FA Jakobiec SL Trokel D Aron-Rosa T Iwamoto D Doyon 《Canadian Metallurgical Quarterly》1980,98(10):1814-1820
Four patients (aged 5, 8, 14, and 51 years at initial manifestation) with isolated eosinophilic granulomas of the orbital frontal bone displayed short symptomatic periods (two weeks to three months) and some combination of erythema of the lids, a soft, palpable anterior orbital mass, periorbital pain, and osteolytic bone lesions on roentgenography. The bone lesions roentgenographically exhibited irregular, serrated, and sclerotic margins, distinguishing them from the more oval appearance of dermoid cysts. Electron microscopy performed in one case disclosed the presence of Langerhans' granules in the cytoplasm of the histiocytes, indicating that the orbital disease is a mild form of "histiocytosis X" and a benign proliferation of a specific kind of histiocyte--the Langerhans' cell. On follow-up (two to 20 years), after incomplete curettage of two lesions coupled with low doses of postoperative radiotherapy, there was reconstitution of the bone defects, whereas more extensive surgery performed on the other two patients resulted in permanent but subclinical bone defects. 相似文献
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54.
Survey of Motion Planning Literature in the Presence of Uncertainty: Considerations for UAV Guidance
This paper provides a survey of motion planning techniques under uncertainty with a focus on their application to autonomous guidance of unmanned aerial vehicles (UAVs). The paper first describes the primary sources of uncertainty arising in UAV guidance and then describes relevant practical techniques that have been reported in the literature. The paper makes a point of distinguishing between contributions from the field of robotics and artificial intelligence, and the field of dynamical systems and controls. Mutual and individual contributions for these fields are highlighted providing a roadmap for tackling the UAV guidance problem. 相似文献
55.
The ongoing integration of Information Technology (IT) into various areas of our lives has led to a plethora of digital products and services. To survive competition in the long run, these offerings not only have to keep up with constant technological developments, but also have to adapt from a business point of view. Managers of these digital businesses have to especially focus on the design and evolution of their business’ revenue mechanisms to ensure the viability of their offerings. The related decisions are not trivial, as managers have to be aware of the relevant contextual factors and have to react quickly to changes in the environment. This paper proposes a viability theory for digital businesses described by 17 propositions that may guide managers in the design of revenue mechanisms and thereby support the evolution as well as the viability of a digital business. 相似文献
56.
低剂量率γ射线杀伤肿瘤细胞机制的实验研究 总被引:4,自引:0,他引:4
用60Co源以1Gy/min剂量率照射Hela细胞,剂量分别为1、2、5、10、15Gy.用AnnexinV和PI双染法观察凋亡细胞形态;DNA梯形条带证实凋亡存在;克隆形成分析细胞增殖能力.结果显示:(1)Hela细胞凋亡率随照射剂量和时间的增加呈上升趋势,照射后168h组各剂量点凋亡率高于其他各时间组.2Gy以下时凋亡率改变不大,达5Gy时凋亡率显著增加,且达峰值(72.57±2.04)%(P<0.001).(2)早期凋亡细胞,PS外翻,胞膜呈绿色荧光圈.凋亡晚期出现Annexin V-FITC及PI染色均阳性的外绿内红的细胞图像.坏死细胞则为红色.(3)凋亡细胞碎片呈"梯状"条带.(4)1Gy/min的剂量率照射,剂量为2-15Gy,克隆形成率由(58.95±0.36)%降至(1.67±0.35)%(P<0.001).表明低剂量率γ射线照射可诱导Hela细胞凋亡,其凋亡率与照射剂量相关,在5Gy时凋亡率最高. 相似文献
57.
58.
The change of operating parameters above threshold of (Ga, Al)As injection lasers with aging time was calculated assuming a uniform mode of degradation mechanism with temperature-dependent degradation rates. In the calculation, the degradation rate for the threshold current was assumed to be temperature dependent, but not explicitly dependent on aging time and pumping current. Optical output power was kept constant during aging. The calculated time variation of laser parameters predicts a runaway after an initial slow rise. The mathematical model thus provides the means to correlate time-to-failure data with initial degradation rates and permits the evaluation of the influence of various laser parameters on lifetime. A selected group of laser diodes were aged at 80 °C under the conditions specified by the model. Degradation rates for the threshold current varied between4 times 10^{-5} and5 times 10^{-4} h-1. These would extrapolate to lifetimes in excess of 10 000 h at the elevated temperature for half of the diodes in reasonable agreement with experimental values obtained by others. 相似文献
59.
浅谈土壤源热泵系统的发展及其应用 总被引:1,自引:0,他引:1
概述了土壤源热泵系统的特点,阐述了土壤源热泵技术在国内外的发展、研究现状,最后介绍了土壤源热泵技术在发展中面临的问题及在制冷空调中的广阔应用前景。 相似文献
60.