Effects of solute elements on hardening and microstructural evolution in neutron-irradiated and thermally-aged reactor pressure vessel model alloys

Nanometer-sized Cu-enriched solute clusters containing Mn, Ni, and Si atoms are considered as the primary embrittling feature in reactor pressure vessel steels. In order to understand the effects of solute atoms Mn, Ni, and Si on hardening and cluster formation, reactor pressure vessel model alloys FeCu, FeCuSi, FeCuNi, and FeCuNiMn were irradiated at 290 °C in a research reactor. Thermal ageing at 450 °C was also carried out to compare with the results in the neutron irradiation. The addition of Mn resulted in larger hardening and higher cluster number density in both thermal ageing and neutron irradiation. In FeCu0.8NiMn alloy, the size distribution of Cu-enriched clusters formed in 62-h thermal ageing (almost peak hardening) was very similar to that formed in the neutron irradiation, indicating they are on a similar growing stage. But the average Ni and Mn composition in clusters formed in neutron irradiation was higher. A good linear relationship between hardening and the square root of cluster volume fraction for both neutron irradiation and thermal ageing data was found.     

Molecular weight distribution of carrageenans studied by a combined gel permeation/inductively coupled plasma (GPC/ICP) method

Degraded carrageenan (known as poligeenan, molecular weight: 20kDa to 30kDa) causes ulcerative colitis in experimental animals. In this paper, the molecular weight distributions of 29 samples of food-grade refined carrageenans were studied by high performance liquid gel permeation chromatography (GPC) directly connected to vacuum-ultraviolet inductively coupled plasma-atomic emission spectrometry (ICP) (GPC/ICP) as well as GPC/refractive index (RI) detection. All samples of food-grade carrageenan had a major broad peak of high molecular weight which eluted at around 6.5min in both RI and ICP mode (sulphur and carbon), and each sample of them had no obvious peak of poligeenan (the detection limit was about 5%). The number average molecular weights of these carrageenans ranged from 193 kDa to 324kDa, and the weight average molecular weights ranged from 453kDa to 652kDa based on RI data. Some samples had a few minor peaks which eluted around 10-12min. These peaks came from ionic sulphate, sucrose or glucose. It was considered that if the data-sampling programme was improved, the GPC/ICP system would become a more powerful technique for evaluation of carrageenan samples containing ionic substances and sugar.     

Influence of Ni and Co on methanogenic activity and the amounts of coenzymes involved in methanogenesis

The requirement of Ni²⁺ and Co²⁺ addition on methanogenic activity and the coenzymes involved in methanogenesis were investigated in anaerobic continuous cultivation with synthetic wastewater using acetate as the sole carbon source. Addition of Ni²⁺ and Co²⁺ to the synthetic wastewater drastically increased the maximum dilution rate of the cultivation. The concentrations of coenzymes F₄₃₀ and corrinoids in the biomass increased to 0.62 μmol-Ni/g-VSS and 0.67 μmol-Co/g-VSS, respectively with the increase of the dilution rate. Methanogenic activity of the culture broth also increased with an increase of dilution rate. However, without addition of Ni²⁺ and Co²⁺, F₄₃₀ and corrinoids were not detected in the biomass and methanogenic activity was only a trace level at a dilution rate of 0.025 d⁻¹. When the amounts of Ni²⁺ and Co²⁺ added at a dilution rate of 0.6 d⁻¹ were lowered in steps, the concentrations of F₄₃₀ and corrinoids in the biomass and methanogenic activity decreased with decreasing amounts of Ni²⁺ and Co²⁺ added. These results suggest that Ni²⁺ and Co²⁺ were required for the methane-producing reactions via increases of coenzymes F₄₃₀ and corrinoids.     

Leptolstatin from Streptomyces sp. SAM1595, a new gap phase-specific inhibitor of the mammalian cell cycle. II. Physico-chemical properties and structure

Leptolstatin, a product from Streptomyces sp. SAM1595, is a gap phase-specific inhibitor of the mammalian cell cycle. Physico-chemical properties and spectrometric analyses showed that the structure of leptolstatin is (2Z,6E,8Z,12E,14E,22E)-19,24-dihydro xy-8,10,14,16,18,20,22-heptamethyl-17-oxo-2 , 6,8,12,14,22-tetracosahexaen-5-olide.     

Detection of new spider toxins from a Nephilengys borbonica venom gland using on-line mu-column HPLC continuous flow (FRIT) FAB LC/MS and MS/MS

The Morris water maze is frequently used to screen mutant mice generated by gene targeting. Targeted ES-cells are often derived from 129/Sv or BALB/c mice, known as poor swimming navigation learners. After mating the founders with C57BL/6 mice, the F2 or F3 hybrid generation is typically used for behavioral testing. In hybrid 129/Sv x C57BL/6 mice, a modification of the betaAPP gene entails impaired swimming navigation learning. This is readily detected despite behavioral variability, because wild-type 129/Sv x C57BL/6 hybrids outperform either of the parental strains and provide a control sample with good baseline performance. However, after backcrossing to the 129/Sv(ev) strain, the mutation effects are no longer detectable, masked by the very poor performance of wild-type 129/Sv(ev) mice. We conclude that F2 and F3 generations of 129/Sv x C57BL/6 crosses provide a suitable genetic background for behavioral testing of transgenic mice, provided that the samples are large enough to compensate for genetic and epigenetic variability and provided that normal performance in the control group is verified by comparison against a large database of mice tested under identical conditions. Creating congenic lines by backcrossing to an inbred strain is unlikely to enhance the sensitivity of the Morris test. Backcrossing to 129/Sv(ev) may even reduce it.     

A 20 Gbps inductorless CMOS optical receiver for short-distance VCSEL-based 850 nm optical links

This paper presents a circuit design and experimental results for a 20 Gbps CMOS inductorless optical receiver, a transimpedance amplifier (TIA) and a limiting amplifier, for a vertical-cavity surface emitting laser based 850 nm optical link. The proposed optical receiver apply a power supply noise canceling technique, an additional path from the power supply to the TIA output to generate a reversed phase signal that reduces the power supply noise, and bandwidth enhancement circuit design that dose not require internal inductors. The simulation results shows a power supply rejection ratio of ?96.6 dB at 10 MHz, a total gain of $82.8\,\hbox{dB}\Upomega$ and a ?3 dB bandwidth of 15.5 GHz. A test chip fabricated in 90 nm CMOS technology and demonstrated with a PIN photo-diode, a bandwidth of 17 GHz and a responsibility of 0.53 A/W. The measurement results show a 25 % eye opening and an input sensitivity of ?7.1 dBm at a bit error rate of 10^?12 with a 2⁹ ? 1 pseudo-random test pattern at 20 Gbps. The core circuit of the optical receiver occupies only an area of 0.02 mm².     

Preparation of Bi0.5Sb1.5Te3 Thermoelectric Materials by Pulse-Current Sintering Under Cyclic Uniaxial Pressure

The effects of applying cyclic uniaxial pressure during the pulse-current sintering process on the crystal alignment and thermoelectric properties of p-type Bi_0.5Sb_1.5Te₃ were investigated. Sintering was performed at 673 K using pulse-current heating under 70 MPa or 100 MPa of cyclic uniaxial pressure. x-Ray diffraction patterns and electron backscattered diffraction analyses showed that application of the cyclic uniaxial pressure enhanced crystal grain orientation. The texture consisted of flattened crystal grains stacked in the thickness direction of the sintered materials. The hexagonal c-plane strongly tended to align in the direction perpendicular to the uniaxial pressure. Owing to the crystal alignment, the Hall mobility in the direction perpendicular to the uniaxial pressure became larger than that of equivalent samples prepared with a constant uniaxial pressure. As a result of the increase in Hall mobility, the resistivity of the material was decreased while the equivalent Seebeck coefficient was maintained and the power factor was improved.     

A 0.11 μm CMOS technology featuring copper and very low k interconnects with high performance and reliability

This paper describes a 0.11 μm CMOS technology with high-reliable copper (Cu) and very low k (VLK) (k<2.7) interconnects for high-performance and low-power applications of a 0.13 μm generation. Aggressive design rules, 0.11 μm gate transistor and 2.2 μm² six-transistor SRAM cell are realized by using KrF 248 nm lithography, optical proximity effect correction, and gate-shrink techniques. Eight-level interconnects are fabricated with seven level of Cu/VLK interconnect and one level of Al/SiO₂ interconnect. Drain current of 0.67 and 0.28 mA/μm are realized for nMOSFET and pMOSFET with 0.11 μm gate, respectively. Propagation delay of two input NAND with the Cu/VLK interconnect is estimated. The delay is improved by more than 70%, compared to 0.18 μm CMOS technology with Cu/FSG interconnects. Functional 288 kbit SRAM circuit is demonstrated with 2.2 μm² cell and Cu/VLK interconnect.