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排序方式: 共有428条查询结果,搜索用时 15 毫秒
31.
Nobuyoshi Ohno Sobahan Mia Kazuo Masuhara Kentaro Sonoda Yuji Yamashita Yoshitaka Tamura 《摩擦学汇刊》2013,56(5):722-730
The tribological properties of a new and unique thermoreversible gel lubricant (TR gel lube) were investigated. TR gel lube, which includes 10–40% of amide-type gelling agent in base fluid, is able to repeatedly alter or convert phase from gel state to liquid state at the melting point of the gelling agent. High-pressure rheological tests were performed in order to characterize the behavior of base oil and TR gel lube as a function of pressure and temperature. The effect of TR gel lube on ball bearing fatigue life was carried out by systematic tests using thrust ball bearings. The results of L 10 life tests of TR gel lube showed a longer life than the conventional greases. This result was investigated from the oil film formation. It was found that the gelling agent played a key role in the lubricating properties. Some mechanisms such as adsorbed film formation and solid-like formation are proposed. 相似文献
32.
Damage and replication checkpoint control in fission yeast is ensured by interactions of Crb2, a protein with BRCT motif, with Cut5 and Chk1 总被引:1,自引:0,他引:1
Y Saka F Esashi T Matsusaka S Mochida M Yanagida 《Canadian Metallurgical Quarterly》1997,11(24):3387-3400
Fission yeast Cut5/Rad4 plays a unique role in the genome maintenance as it is required for replication, replication checkpoint, and normal UV sensitivity. It is unknown, however, how Cut5 protein is linked to other checkpoint proteins, and what part it plays in replication and UV sensitivity. Here we report that Cut5 interacts with a novel checkpoint protein Crb2 and that this interaction is needed for normal genome maintenance. The carboxyl terminus of Crb2 resembles yeast Rad9 and human 53BP1 and BRCA1. Crb2 is required for checkpoint arrests induced by irradiation and polymerase mutations, but not for those induced by inhibited nucleotide supply. Upon UV damage, Crb2 is transiently modified, probably phosphorylated, with a similar timing of phosphorylation in Chk1 kinase, which is reported to restrain Cdc2 activation. Crb2 modification requires other damage-sensing checkpoint proteins but not Chk1, suggesting that Crb2 acts at the upstream of Chk1. The modified Crb2 exists as a slowly sedimenting form, whereas Crb2 in undamaged cells is in a rapidly sedimenting structure. Cut5 and Crb2 interact with Chk1 in a two-hybrid system. Moreover, moderate overexpression of Chk1 suppresses the phenotypes of cut5 and crb2 mutants. Cut5, Crb2, and Chk1 thus may form a checkpoint sensor-transmitter pathway to arrest the cell cycle. 相似文献
33.
SG Ellis H Tamai M Nobuyoshi K Kosuga A Colombo DR Holmes C Macaya CL Grines PL Whitlow HJ White J Moses PS Teirstein PW Serruys JA Bittl MR Mooney TM Shimshak PC Block R Erbel 《Canadian Metallurgical Quarterly》1997,96(11):3867-3872
BACKGROUND: Coronary artery bypass surgery (CABG) has been considered the therapy of choice for patients with unprotected left main (ULMT) coronary stenoses. Selected single-center reports suggest that the results of percutaneous intervention may now approach those of CABG. METHODS AND RESULTS: To assess the results of percutaneous ULMT treatment from a wide variety of experienced interventional centers, we requested data on consecutive patients treated after January 1, 1994, from 25 centers. One hundred seven patients were identified who were treated either electively (n=91) or for acute myocardial infarction (n=16). Of patients treated electively, 25% were considered inoperable, and 27% were considered high risk for bypass surgery. Primary treatment included stents (50%), directional atherectomy (24%), and balloon angioplasty (20%). Follow-up was 98.8% complete at 15+/-8 months. Results varied considerably, depending on presentation and treatment. For patients with acute myocardial infarction, technical success was achieved in 75%, and survival to hospital discharge was 31%. For elective patients, technical success was achieved in 98.9%, and in-hospital survival was strongly correlated with left ventricular ejection fraction (P=.003). Longer-term event (death, infarction, or bypass surgery) -free survival was correlated with ejection fraction (P<.001) and was inversely related to presentation with progressive or rest angina (P<.001). Surgical candidates with ejection fractions > or = 40% had an in-hospital survival of 98% and a 9-month event-free survival of 86+/-5%, whereas patients with ejection fractions < 40% had 67% and 22+/-12% in-hospital and 9-month event-free survivals, respectively. Nine hospital survivors (10.6%) experienced cardiac death within 6 months of hospital discharge. CONCLUSIONS: While results for selected patients appear promising, until early post-hospital discharge cardiac death can be better understood and minimized, percutaneous revascularization of ULMT stenosis should not be considered an alternative to bypass surgery for most patients. When percutaneous revascularization of ULMT is required, directional atherectomy and stenting appear to be the preferred techniques, and follow-up angiography 6 to 8 weeks after treatment is probably advisable. 相似文献
34.
Intricate interplay may exist between pre-mRNA splicing and the cell division cycle, and fission yeast Dsk1 appears to play a role in such a connection. Previous genetic analyses have implicated Dsk1 in the regulation of chromosome segregation at the metaphase/anaphase transition. Yet, its protein sequence suggests that Dsk1 may function as a kinase specific for SR proteins, a family of pre-mRNA splicing factors containing arginine-serine repeats. Using an in vitro system with purified components, we showed that Dsk1 phosphorylated human and yeast SR proteins with high specificity. The Dsk1-phosphorylated SF2/ASF protein was recognized strongly by a monoclonal antibody (mAb104) known to bind the in vivo phosphoepitope shared by SR proteins, indicating that the phosphorylation sites resided in the RS domain. Moreover, the fission yeast U2AF65 homolog, Prp2/Mis11 protein, was phosphorylated more efficiently by Dsk1 than by a human SR protein-specific kinase, SRPK1. Thus, these in vitro results suggest that Dsk1 is a fission yeast SR protein-specific kinase, and Prp2/Mis11 is likely an in vivo target for Dsk1. Together with previous genetic data, the studies support the notion that Dsk1 may play a role in coordinating pre-mRNA splicing and the cell division cycle. 相似文献
35.
Nobuko Onozawa-Komatsuzaki Masatoshi Yanagida Takashi Funaki Kazuyuki Kasuga Kazuhiro Sayama Hideki Sugihara 《Inorganic chemistry communications》2009,12(12):1212-1215
A new ruthenium(II)–polypyridine complex (1) having a 2,6-bis(4-carboxyquinolin-2-yl)pyridine ligand was synthesized as a sensitizer for dye-sensitized solar cells (DSCs). This complex exhibited remarkable light-harvesting properties in the near-IR region. DSCs sensitized with 1 showed a 35% incident photon-to-current conversion efficiency (IPCE) at 900 nm. 相似文献
36.
Selective copper CVD technique involving hydrogen reduction of hexafluoro acetylacetonate copper has been used to fill vias
for fabricating double-level copper interconnect structure. The surface morphology of selectively deposited copper on copper
substrate of the via bottom depends strongly on via opening process. A two-step via opening process consisting of an reactive
ion etching of the insulating interlayer and a wet removal of the interlayer metal results in smooth copper plug formation
by CVD. Double-level copper interconnect structures have been fabricated using this technique and a via resistance as low
as 100 mΩ has been obtained for a 1 μ diameter via. 相似文献
37.
Tatsuki Kitayama Nobutaka Fujimoto Takatsune Yanagida Koichi Hatada 《Polymer International》1994,33(2):165-170
Polymerization of methyl methacrylate (MMA) by isotactic poly(methyl methacrylate) (PMMA) living anion, prepared with t-C4H9MgBr in toluene at ?60°C, was carried out at ?78°C in the presence of trialkylaluminiums (R3Al; R = CH3, C2H5, and n-C4H9) to obtain a stereoblock PMMA, isotactic PMMA-block-syndiotactic PMMA. Among the R3Als, (CH3)3Al gave most effectively the steroblock PMMA with narrow molecular weight distribution. The fraction of rr triad in the syndiotactic PMMA block increased with increase in the ratio of Al/Mg and reached about 76% at a ratio of Al/Mg ≥ 6. The method was also used to prepare stereoblock copolymer comprising isotactic PMMA block and syndiotactic block of butyl methacrylate. Stereocomplex formation and solution viscosity of the stereoblock PMMA were also studied. 相似文献
38.
K Hashimoto C Azuma Y Tokugawa T Nobunaga TA Aki Y Matsui T Yanagida H Izumi F Saji Y Murata 《Canadian Metallurgical Quarterly》1997,28(7):862-865
An unusual clinical presentation of a patient with neuronal intestinal dysplasia is presented. A 46-year-old male noted a palpable mass in the right lower quadrant of his abdomen for two months. A computed axial tomographic scan showed a thickened wall of the cecum with a tumor-like appearance. The excised specimen consisted of a mass caused by the thickened, edematous wall of the dilated cecum and appendix. The wall of the cecum and appendix measured up to 2.5 and 0.8 cm, respectively, in thickness. Microscopic studies showed extensive hyperplasia and hypertrophy of the ganglia and nerve plexuses and hypertrophy of the muscularis propria, consistent with neuronal intestinal dysplasia. 相似文献
39.
40.
Seigo Ito Takayuki Kitamura Yuji Wada Shozo Yanagida 《Solar Energy Materials & Solar Cells》2003,76(1):3-13
A chemical dispersing technique for preparing a coating paste of TiO2 nanoparticles is disclosed to fabricate mesoporous electrodes for dye-sensitized TiO2 solar cells. The suspension of TiO2 (P-25) powder was stirred in aqueous nitric acid at 80°C, and then evaporated to dryness, giving the nitric acid-adsorbed P-25 powder. The coating paste was obtained by mixing the nitric acid-adsorbed P-25 with PEG (Mw 20,000) as a porosity-controlling agent and cellulosic polymer as a thickener. The mesoporous TiO2 films were fabricated on conducting glasses by repetitive coating and calcined at 500°C (30 min). The TiO2 film obtained by the five times repetitive coating (20 μm thickness) resulted in the 1.4 times higher energy conversion efficiency of the dye-sensitized solar cells than that of the one time coating TiO2 film (Voc=690 mV, Jsc=12.2 mA/cm2, the fill FACTOR=0.71 and η=6.0%). 相似文献