Polyphosphoester‐based paclitaxel complexes

We demonstrated a feasible approach for the preparation of a biodegradable, water soluble polyphosphoester based paclitaxel complex. Applying poly(hydroxyoxyethylene phosphate) which contains both a strong proton accepting P?O group and a proton donating P? OH group, paclitaxel has been physically immobilized onto the polymer via H‐bonding. The water soluble complex contained 16.7 wt % paclitaxel and more than 4000 times increased drug solubility was achieved. The polymer‐drug complex formed nanosized aggregates that were characterized by dynamic light scattering. Intravenous injection of poly(hydroxyoxyethylene phosphate) in rats at a dose of 1000 mg/kg did not induce any clinical signs or body weight gain reduction. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42772.     

Fabrication of Langmuir-Blodgett films using amphiphilic peptides

To introduce self-organization ability of transmembrane proteins into Langmuir (L) and Langmuir-Blodgett (LB) techniques, we focused on "amphiphilic peptide" (AP) which is composed of two distinct hydrophilic and hydrophobic domains. Three types of APs of different average hydropathies were used to prepare the AP/lipid mixed L and LB films. According to the circular dichroism spectra, the secondary structures of APs were not uniform but were a mixture of alpha-helix, beta-strand and random coil. The fraction of alpha-helix was higher for lower hydropathy AP. The interaction between AP and lipid in the L film and the structure of the LB film were also depended on the APs used.     

Design, Synthesis, and Catalysis of Bio-inspired Immobilized Metallocomplex Catalyst

Novel immobilized metallocomplex catalyst based on bio-inspired concept has been developed. The allyl functional group in the anionic chelating ligand reacts with thiols to give the linker for immobilization. The immobilization of the chelating ligand onto amorphous silica supports results in the isolated metal-binding sites giving the coordinatively unsaturated metal center. The biomimetic iron complex-immobilized silica exhibits the catalysis for olefin epoxidation with aqueous H₂O₂ at ambient temperature.     

Use of biased neighborhood structures in multiobjective memetic algorithms

In this paper, we examine the use of biased neighborhood structures for local search in multiobjective memetic algorithms. Under a biased neighborhood structure, each neighbor of the current solution has a different probability to be sampled in local search. In standard local search, all neighbors of the current solution usually have the same probability because they are randomly sampled. On the other hand, we assign larger probabilities to more promising neighbors in order to improve the search ability of multiobjective memetic algorithms. In this paper, we first explain our multiobjective memetic algorithm, which is a simple hybrid algorithm of NSGA-II and local search. Then we explain its variants with biased neighborhood structures for multiobjective 0/1 knapsack and flowshop scheduling problems. Finally we examine the performance of each variant through computational experiments. Experimental results show that the use of biased neighborhood structures clearly improves the performance of our multiobjective memetic algorithm.     

Numerical evaluation of the ill-posedness of eddy current problems to size real cracks

This study evaluates whether or not eddy current testing is applicable to the sizing of cracks that appear in a general structure. Two 10 mm thick specimens with artificial stress corrosion cracking are prepared, eddy current testing is performed to gather eddy current signals that result from cracking, and numerical inversions are performed to evaluate the maximum depths of the cracking. The inversions estimate the depths of the cracks are 0.8 and 1.6 mm. Although the simulated signals agree well with the measured ones, destructive tests reveal that the true depths are 1.27 and 2.58 mm. Another numerical simulation is conducted to discuss the ill-posedness of the inverse problem of sizing crack depths from eddy current signals. The simulation simply models a crack as a rectangular region with a constant length and uniform conductivity inside and calculates the eddy current signals of 1024 cracks having variety of depths, widths, and conductivities. Analyzing the results of the simulation reveal that information contained in conventional single-frequency eddy current tests is not sufficient to size conductive cracks in a general sense.     

Properties of Nitrogen-Containing Yttria—Alumina—Silica Melts and Glasses

The viscosity and solubility of nitrogen in Y₂O₃–Al₂O₃–SiO₂ melts have been systematically examined. The effects of nitrogen content on viscosity for Y-Al-Si-O-N melts and on Vickers hardness of oxynitride glasses also have been examined. Although the viscosity of Y₂O₃–Al₂O₃–SiO₂ melts was decreased, the solubility of nitrogen into the melts was increased with increased Y₂O₃ content. These results indicated that the yttrium ion behaved as a network modifier. Therefore, the structural units for viscous flow became small, and the amount of nonbridging oxygen increased in the melts when the Y₂O₃ content increased. The viscosity of Y-Al-Si-O-N melts and Vickers hardness of oxynitride glasses remarkably increased with increased nitrogen content. These results suggested that the substitution of nitrogen for oxygen in the melts may have led to a high average coordination of nonmetal atoms and that the increased cross-linking produced a more rigid glass network.     

Electrostatic Cleaning System for Removing Lunar Dust Adhering to Space Suits

Removing lunar dust adhering to astronaut space suits is critically important for long-term lunar exploration. We are developing an automatic cleaning system that uses electrostatic force. It employs an alternating electrostatic field that forms a barrier on the surface of fabrics. In this study, we applied single-phase rectangular voltage to parallel wire electrodes stitched into the insulating fabric of space suits. By applying mechanical vibration and operating the system in a vacuum, we realized high performance: the cleaning rate exceeded 80%. Flicking out particles smaller than 10?μm in diameter that were trapped between fibers was difficult, but this system can perform preliminary space suit cleaning and save precious time for astronauts on the moon.     

Enhancements of eddy current testing techniques for quantitative nondestructive testing of key structural components of nuclear power plants

In this paper, studies on upgrade of eddy current testing (ECT) techniques for inspection of stress corrosion cracks (SCC) in key structural components of a nuclear power plant are reported. Access and scanning vehicle (robot), advanced probes for steam generator (SG) tube inspection, developments and evaluations of new ECT probes for welding joint, and ECT-based crack sizing technique are described, respectively. Based on these techniques, it is demonstrated that ECT can play as a supplement of ultrasonic testing (UT) for the quantitative inspection of welding zone. It is also proved in this work that new ECT sensors are efficient even for inspection of a stainless steel plate as thick as 15 mm.     

Application of eddy current inversion technique to the sizing of defects in Inconel welds with rough surfaces

This paper evaluates the applicability of eddy current inversion techniques to the sizing of defects in Inconel welds with rough surfaces. For this purpose, a plate Inconel weld specimen, which models the welding of a stub tube in a boiling water nuclear reactor is fabricated, and artificial notches machined into the specimen. Eddy current inspections using six different eddy current probes are conducted and efficiencies were evaluated for the six probes for weld inspection. It is revealed that if suitable probes are applied, an Inconel weld does not cause large noise levels during eddy current inspections even though the surface of the weld is rough. Finally, reconstruction of the notches is performed using eddy current signals measured using the uniform eddy current probe that showed the best results among the six probes in this study. A simplified configuration is proposed in order to consider the complicated configuration of the welded specimen in numerical simulations. While reconstructed profiles of the notches are slightly larger than the true profiles, quite good agreements are obtained in spite of the simple approximation of the configuration, which reveals that eddy current testing would be an efficient non-destructive testing method for the sizing of defects in Inconel welds.