The course of geriatric depression with "reversible dementia": a controlled study

OBJECTIVE: The goals of this longitudinal investigation were 1) to study the rate of development of irreversible dementia in elderly depressed patients with a dementia syndrome that subsided after improvement of depression and 2) to compare it with that of depressed, never-demented patients. METHOD: The subjects were 57 elderly patients consecutively hospitalized for major depression. At entry into the study, 23 subjects also met criteria for "reversible dementia," while 34 were without dementia. After a systematic clinical evaluation, the subjects were followed up at approximately yearly intervals for an average of 33.8 months. RESULTS: Irreversible dementia developed significantly more frequently in the depressed group with reversible dementia (43%) than in the group with depression alone (12%). Survival analysis showed that the group with reversible dementia had a 4.69-times higher chance of having developed dementia at follow-up than the patients with depression alone. No clinical characteristics at entry into the study were found to discriminate the subjects who developed irreversible dementia during the follow-up period from those who remained nondemented. CONCLUSIONS: These findings suggest that geriatric depression with reversible dementia is a clinical entity that includes a group of patients with early-stage dementing disorders. Therefore, identification of a reversible dementia syndrome is an indication for a thorough diagnostic workup and frequent follow-ups in order to identify treatable neurological disorders.     

Dislocations of the upper extremity in children

Traumatic dislocations and subluxations of the upper extremity in children have been surveyed. The elbow joint is most commonly dislocated and is dislocated more frequently in children than in adults. Severe neurovascular injury may be associated with dislocation of this joint. The most common subluxation is that of the radial head, secondary to a "pulled elbow." Otherwise dislocations and subluxations of the upper extremity are uncommon in children, apparently because of the relative weakness of the epiphyseal plate. Most of these injuries are the result of predictable indirect forces. Principles of reduction and immobilization are based on the unique anatomic structure of the joint involved and the known anatomic disruption resulting from the trauma.     

Comparative analysis of experimental performance and stability of sensorless induction motor drives

This paper compares the experimental performance of three flux and speed observers for speed-sensorless induction motor drives and discusses the cause of their differences. The small signal analysis using the linearized model is carried out to analyze stability. Three methods are generally accepted to be representative candidates for high sensorless performance, namely: 1) rotor-flux model reference adaptive system (MRAS); 2) torque-current MRAS; and 3) adaptive nonlinear flux observer. Many other sensorless methods improved these methods. The paper discusses baseline conditions for the experiments and the stability analysis, which include matched load inertia, specified speed estimator dynamics, and sensorless operation within a speed control loop. For the comparison tests in the paper, the speed estimation dynamics of the methods are the same; this is important for parameter sensitivity. The paper concentrates on the low-speed performance, and all results shown are under sensorless speed control.     

Compact beam expander with linear gratings

Novel compact beam expanders that could be useful for applications such as providing light to flat panel displays are presented. They are based on a planar configuration in which three spatially linear gratings are recorded on one transparent substrate, so as to expand a narrow incoming beam in two dimensions. We present the design and recording procedures along with results, showing a relatively uniform intensity of the wide output beam. Such expanders can serve for illuminating flat panel displays.     

Effects of foam on ocean surface microwave emission inferred from radiometric observations of reproducible breaking waves

WindSat, the first satellite polarimetric microwave radiometer, and the NPOESS Conical Microwave Imager/Sounder both have as a key objective the retrieval of the ocean surface wind vector from radiometric brightness temperatures. Available observations and models to date show that the wind direction signal is only 1-3 K peak-to-peak at 19 and 37 GHz, much smaller than the wind speed signal. In order to obtain sufficient accuracy for reliable wind direction retrieval, uncertainties in geophysical modeling of the sea surface emission on the order of 0.2 K need to be removed. The surface roughness spectrum has been addressed by many studies, but the azimuthal signature of the microwave emission from breaking waves and foam has not been adequately addressed. Recently, a number of experiments have been conducted to quantify the increase in sea surface microwave emission due to foam. Measurements from the Floating Instrumentation Platform indicated that the increase in ocean surface emission due to breaking waves may depend on the incidence and azimuth angles of observation. The need to quantify this dependence motivated systematic measurement of the microwave emission from reproducible breaking waves as a function of incidence and azimuth angles. A number of empirical parameterizations of whitecap coverage with wind speed were used to estimate the increase in brightness temperatures measured by a satellite microwave radiometer due to wave breaking in the field of view. These results provide the first empirically based parameterization with wind speed of the effect of breaking waves and foam on satellite brightness temperatures at 10.8, 19, and 37 GHz.     

Characterization of the radical trapping activity of a novel series of cyclic nitrone spin traps

alpha-Phenyl-tert-butyl nitrone (PBN) is a nitrone spin trap, which has shown efficacy in animal models of oxidative stress, including stroke, aging, sepsis, and myocardial ischemia/reperfusion injury. We have prepared a series of novel cyclic variants of PBN and evaluated them for radical trapping activity in vitro. Specifically, their ability to inhibit iron-induced lipid peroxidation in liposomes was assessed, as well as superoxide anion (O2(-.)) and hydroxyl radical ((.)OH) trapping activity as determined biochemically and using electron spin resonance (ESR) spectroscopy. All cyclic nitrones tested were much more potent as inhibitors of lipid peroxidation than was PBN. The unsubstituted cyclic variant MDL 101,002 was approximately 8-fold more potent than PBN. An analysis of the analogs of MDL 101,002 revealed a direct correlation of activity with lipophilicity. However, lipophilicity does not solely account for the difference between MDL 101,002 and PBN, inasmuch as the calculated octanol/water partition coefficient for MDL 101,002 is 1.01 as compared to 1.23 for PBN. This indicated the cyclic nitrones are inherently more effective radical traps than PBN in a membrane system. The most active compound was a dichloro analog in the seven-membered ring series (MDL 104,342), which had an IC50 of 26 mum, which was 550-fold better than that of PBN. The cyclic nitrones were shown to trap (.)OH with MDL 101,002 being 20 25 times more active than PBN as assessed using 2-deoxyribose and p-nitrosodimethylaniline as substrates, respectively. Trapping of (.)OH by MDL 101,002 was also examined by using ESR spectroscopy. When Fenton's reagent was used, the (.)OH adduct of MDL 101,002 yielded a six-line spectrum with hyperfine coupling constants distinct from that of PBN. Importantly, the half-life of the adduct was nearly 5 min, while that of PBN is less than 1 min at physiologic pH. MDL 101,002 also trapped the O2(-.) radical to yield a six-line spectrum with coupling constants very distinct from that of the (.)OH adduct. In mice, the cyclic nitrones ameliorated the damaging effects of oxidative stress induced by ferrous iron injection into brain tissue. Similar protection was not afforded by the lipid peroxidation inhibitor U74006F, thus implicating radical trapping as a unique feature in the prevention of cell injury. Together, the in vivo activity, the stability of the nitroxide adducts, and the ability to distinguish between trapping of (.)OH and O2(-.) suggest the cyclic nitrones to be ideal reagents for the study of oxidative cell injury.