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71.
We present a multidisciplinary design optimization method for the profile and structural reinforcement layout of a ram‐air kite rib. The aim is to minimize the structural elastic energy and to maximize the traction power of a ram‐air kite used for airborne wind energy generation. Because of the large deformations occurring during flight, a fluid‐structure interaction (FSI) routine is included in the optimization, which determines the actual deformed rib geometry and its corresponding aerodynamic characteristics. A qualitative comparison between FSI inclusion and exclusion in the optimization is given. Discrepancies in airfoil profile and structural layout are observed. 相似文献
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Anaerobic methane oxidation and aerobic methane production in an east African great lake (Lake Kivu) 总被引:1,自引:0,他引:1
Fleur A.E. Roland Cédric Morana François Darchambeau Sean A. Crowe Bo Thamdrup Jean-Pierre Descy Alberto V. Borges 《Journal of Great Lakes research》2018,44(6):1183-1193
We investigated CH4 oxidation in the water column of Lake Kivu, a deep meromictic tropical lake with CH4-rich anoxic deep waters. Depth profiles of dissolved gases (CH4 and N2O) and a diversity of potential electron acceptors for anaerobic CH4 oxidation (NO3?, SO42?, Fe and Mn oxides) were determined during six field campaigns between June 2011 and August 2014. Denitrification measurements based on stable isotope labelling experiments were performed twice. In addition, we quantified aerobic and anaerobic CH4 oxidation, NO3? and SO42? consumption rates, with and without the presence of an inhibitor of SO42?-reducing bacteria activity. Aerobic CH4 production was also measured in parallel incubations with the addition of an inhibitor of aerobic CH4 oxidation. The maximum aerobic and anaerobic CH4 oxidation rates were estimated to be 27?±?2 and 16?±?8?μmol/L/d, respectively. We observed a difference in the relative importance of aerobic and anaerobic CH4 oxidation during the rainy and the dry season, with a greater role for aerobic oxidation during the dry season. Lower anaerobic CH4 oxidation rates were measured in presence of molybdate in half of the measurements, suggesting the occurrence of linkage between SO42? reduction and anaerobic CH4 oxidation. NO3? consumption and dissolved Mn production rates were never high enough to sustain the measured anaerobic CH4 oxidation, reinforcing the idea of a coupling between SO42? reduction and CH4 oxidation in the anoxic waters of Lake Kivu. Finally, significant rates (up to 0.37?μmol/L/d) of pelagic CH4 production were also measured in oxygenated waters. 相似文献
77.
法国海洋冲浪博物馆探索大海与海浪及其在休闲产业、科学和生态方面所扮演的重要角色。设计方案由斯蒂文·霍尔建筑师事务所与索朗·法比亚合作完成。2005年,在与安瑞科·米拉莱斯/贝娜蒂塔·塔格利亚布、布罗谢特·拉宇斯·普埃约、伯纳德·屈米和让·米歇尔·维尔莫特工作室的角逐中获得胜利,赢得国际竞赛大奖。建筑形式来源于"天空下"/"大海下"的空间理念。"天空下"的凹形体量成为主要的户外广场"海洋世界"的一大特色。广场朝向天空和大海开放,视野向远方无限扩展。凹形的结构天花板形成"大海下"的展览空间。 相似文献
78.
Andreas Zehnsdorf Norman Stock Juliane Richter Michael Blumberg Roland A. Müller 《化学,工程师,技术》2016,88(8):1138-1144
There is increasing interest worldwide in the decentralized treatment of gray water. Since ground‐level areas are generally costly, gray‐water treatment can also be carried out using helophyte mats on the roofs of buildings as an alternative. Alongside the water treatment itself, this process also has a positive effect on the indoor climate in the building. In a test carried out under realistic conditions, it was shown that a helophyte mat with a root‐layer depth of 0.1 m and with hydraulic loads per unit up to 15 L m?2d?1 is suitable for treating typical gray water from a residential building. 相似文献
79.
Identification and Structure–Activity Relationship Studies of Small‐Molecule Inhibitors of the Methyllysine Reader Protein Spindlin1 下载免费PDF全文
Dr. Dina Robaa Dr. Tobias Wagner Chiara Luise Dr. Luca Carlino Joel McMillan Dr. Ralf Flaig Prof. Dr. Roland Schüle Prof. Dr. Manfred Jung Prof. Dr. Wolfgang Sippl 《ChemMedChem》2016,11(20):2327-2338
The methyllysine reader protein Spindlin1 has been implicated in the tumorigenesis of several types of cancer and may be an attractive novel therapeutic target. Small‐molecule inhibitors of Spindlin1 should be valuable as chemical probes as well as potential new therapeutics. We applied an iterative virtual screening campaign, encompassing structure‐ and ligand‐based approaches, to identify potential Spindlin1 inhibitors from databases of commercially available compounds. Our in silico studies coupled with in vitro testing were successful in identifying novel Spindlin1 inhibitors. Several 4‐aminoquinazoline and quinazolinethione derivatives were among the active hit compounds, which indicated that these scaffolds represent promising lead structures for the development of Spindlin1 inhibitors. Subsequent lead optimization studies were hence carried out, and numerous derivatives of both lead scaffolds were synthesized. This resulted in the discovery of novel inhibitors of Spindlin1 and helped explore the structure–activity relationships of these inhibitor series. 相似文献
80.
4‐Biphenylalanine‐ and 3‐Phenyltyrosine‐Derived Hydroxamic Acids as Inhibitors of the JumonjiC‐Domain‐Containing Histone Demethylase KDM4A 下载免费PDF全文
Dr. Ludovica Morera Dr. Martin Roatsch Michael C. D. Fürst Dr. Inga Hoffmann Dr. Johanna Senger Mirjam Hau Dr. Henriette Franz Prof. Dr. Roland Schüle Prof. Dr. Markus R. Heinrich Prof. Dr. Manfred Jung 《ChemMedChem》2016,11(18):2063-2083
Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathology of several human cancers. We found that a previously reported hydroxamate‐based histone deacetylase (HDAC) inhibitor (SW55) was also able to weakly inhibit this demethylase with an IC50 value of 25.4 μm . Herein we report the synthesis and biochemical evaluations, with two orthogonal in vitro assays, of a series of derivatives of this lead structure. With extensive chemical modifications on the lead structure, also by exploiting the versatility of the radical arylation with aryldiazonium salts, we were able to increase the potency of the derivatives against KDM4A to the low‐micromolar range and, more importantly, to obtain demethylase selectivity with respect to HDACs. Cell‐permeable derivatives clearly showed a demethylase‐inhibition‐dependent antiproliferative effect against HL‐60 human promyelocytic leukemia cells. 相似文献