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排序方式: 共有1162条查询结果,搜索用时 15 毫秒
51.
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Fbia D. Lobo de S Steffen Backert Praveen K. Nattramilarasu Soraya Mousavi Geoffrey I. Sandle Stefan Bereswill Markus M. Heimesaat Jrg-Dieter Schulzke Roland Bücker 《International journal of molecular sciences》2021,22(16)
Infections by the zoonotic foodborne bacterium Campylobacter jejuni (C. jejuni) are among the most frequent causes of bacterial gastroenteritis worldwide. The aim was to evaluate the relationship between epithelial barrier disruption, mucosal immune activation, and vitamin D (VD) treatment during C. jejuni infection, using intestinal epithelial cells and mouse models focused on the interaction of C. jejuni with the VD signaling pathway and VD treatment to improve C. jejuni-induced barrier dysfunction. Our RNA-Seq data from campylobacteriosis patients demonstrate inhibition of VD receptor (VDR) downstream targets, consistent with suppression of immune function. Barrier-preserving effects of VD addition were identified in C. jejuni-infected epithelial cells and IL-10−/− mice. Furthermore, interference of C. jejuni with the VDR pathway was shown via VDR/retinoid X receptor (RXR) interaction. Paracellular leakiness of infected epithelia correlated with tight junction (TJ) protein redistribution off the TJ domain and apoptosis induction. Supplementation with VD reversed barrier impairment and prevented inhibition of the VDR pathway, as shown by restoration of transepithelial electrical resistance and fluorescein (332 Da) permeability. We conclude that VD treatment restores gut epithelial barrier functionality and decreases bacterial transmigration and might, therefore, be a promising compound for C. jejuni treatment in humans and animals. 相似文献
53.
David Wenger Wolfgang Polifke Eberhard Schmidt-Ihn Tarek Abdel-Baset Steffen Maus 《International Journal of Hydrogen Energy》2009
In recent years, significant research and development efforts were spent on hydrogen storage technologies with the goal of realizing a breakthrough for fuel cell vehicle applications. This article scrutinizes design targets and material screening criteria for solid state hydrogen storage. Adopting an automotive engineering point of view, four important, but often neglected, issues are discussed: 1) volumetric storage capacity, 2) heat transfer for desorption, 3) recharging at low temperatures and 4) cold start of the vehicle. The article shall help to understand the requirements and support the research community when screening new materials. 相似文献
54.
CMDE has been successfully applied in several industrial projects, including telecommunication services, supply-chain management, bioinformatics, logistics, and healthcare. In all these cases, agility at the customer, user, and application level proved key to aligning and linking business and IT. We now expect an additional boost when integrating this approach into a processor project-management environment that oversees development and evolution. This environment will include deadline management and progress reports, automatically informing all relevant parties when certain actions are required, managing different versions and product lines, and automatically steering the build and quality-management process. Perhaps not surprisingly, the development of this management environment proved to be a prime application of CMDE. 相似文献
55.
Uwe Weigmann Knut Deimer Christian Leininger Ludwig Turba Steffen Jurran 《e & i Elektrotechnik und Informationstechnik》2002,119(11):a19-a19
Firmen&ProdukteDehn Austria
überspannungs-schutz in der Telekommunikation 相似文献56.
With its strong emphasis on modularization, service-oriented computing radically alters the way business processes are modeled, realized, and maintained. Domain-specific services virtualize complex functions of the underlying business applications so that they can be loosely coupled to form transorganizational processes. This level of abstraction fosters agility and lessens traditional provider dependence. Service-oriented design has long driven the development of the telecommunications infrastructure and applications, especially intelligent network services. Applying the same principles of domain specificity, visualization, loose coupling, and seamless vertical integration to business processes has the potential to lead to a new generation of personalized, secure, and highly available Web services 相似文献
57.
Steffen Jørgensen Author Vitae Author Vitae Georges Zaccour Author Vitae 《Automatica》2006,42(8):1349-1355
The paper considers a problem of how to minimize advertising costs to sell seats for a particular event, for instance, a sports game, a rock concert or a ballet performance. We take into consideration a word-of-mouth effect, which means that people buying a ticket tell their friends about it, so that advertising is unnecessary to inform those people.The problem is one of optimal control and the number of seats sold and the advertising effort of the organizers are the state and control variables, respectively. We show that, besides being dependent on the cost and revenue parameters, the optimal advertising policy is also affected by the length of the planning period and the relation between the number of seats and the total number of potential attendees. 相似文献
58.
Disruptions like the breakdown of machines or delays in the delivery of materials cause generated production plans to be useless, at least in some parts. A new planning approach for coping with this uncertainty caused by disruptions is presented. Planning steps that are described by properties, preconditions and consequences are used for material requirements planning and scheduling. If their preconditions are satisfied in a certain state of environment, planning steps will be applicable. The consequences of planning steps change the state of environment. Each customer order establishes a goal of a new planning problem to be achieved by applying planning steps. Plan execution concerns all planning steps applicable in a certain state of environment. In choosing among applicable planning steps and among available resources the flexibility of plan execution is preserved. 相似文献
59.
DK Ball GA Surveyor JR Diehl CL Steffen M Uzumcu MA Mirando DR Brigstock 《Canadian Metallurgical Quarterly》1998,59(4):828-835
60.