Selective adsorption of bilirubin by macroporous poly(glycidyl methacrylate-co-divinylbenzene) beads

Macroporous glycidyl methacrylate (GMA)-divinylbenzene (DVB) copolymer beads have been synthesized and the adsorption of bilirubin, albumin and other serum components were studied. The beads composed of DVB/GMA in the weight ratio of 75/25 provide an excellent bilirubin adsorption ability. When the surface of the beads was previously coated with albumin, discriminating adsorption of the bilirubin in the serum was attained and the adsorption of albumin was depressed. In addition, when the coated albumin was crosslinked with glutaraldehyde, the excellent bilirubin adsorption ability was maintained, however, an adsorption of albumin from the serum occurred.     

Immunocytochemical localization of aromatase-containing neurons in the rat brain during pre- and postnatal development

This article discusses the existence of both spouse abuse and child abuse within families. Recent research suggests that practitioners have often missed the coexistence of these problems within their caseloads. Practice implications for both domestic violence service providers and child welfare professionals are outlined. Recommendations for changes in assessment procedures, treatment planning, and implementation are made.     

Average Bond Dissociation Energies of Fullerene

Average carbon-carbon bond dissociation energy of buckminsterfullerene C₆₀ is estimated to be 106.87 kcal/mol by using experimentally determined thermochemical data. With a few assumptions this value was converted to the following bond-specific dissociation energies for fullerenes in general: 112.04 kcal/mol for 6/6 type bond, and 104.88 for 5/6 type. Similarly an average value of 60.34 kcal/mol was assigned to 5/5 type bond.     

Preparation of an activity-inhibiting monoclonal antibody against human placental aromatase cytochrome P450

We produced a murine monoclonal antibody (MAb) to human placental aromatase cytochrome P450. This MAb, designated MAb3-2C2, was selected on its ability to suppress aromatase activity. The specificity of this MAb was assessed by selective immunoprecipitation of 125I-labeled aromatase cytochrome P450 as well as by the identification of a 55-kDa protein, which was enriched and purified by immunoaffinity chromatography on a MAb-coupled Sepharose 4B column. The MAb was able to suppress both human placental and ovarian microsomal aromatase. Species differences of aromatase were recognized by MAb3-2C2 on the basis of differential immunosuppression of aromatase activity. The antibody had no effect on non-aromatase cytochrome P450s. MAb3-2C2 gave negative results with human placental aromatase P450 in the Western blot analysis. The data presented indicate that MAb3-2C2 is specific for aromatase cytochrome P450 and that its epitope is located in a fragile tertiary conformation of the enzyme, thus making it capable of sensitively affecting catalysis.     

Thermal oxidative deterioration and its prevention in Nd-Fe-B series plastic magnets

Thermal oxidative behaviour of Nd-Fe-B series magnetic powders and effects of surface treatment of the powders with polyacrylonitrile (PAN) and coupling agents on thermal oxidation were examined by thermal analysis (thermogravimetric and differential thermal). In addition, plastic magnets were prepared with magnetic powders (untreated, pre-oxidized and PAN treated) and nylon 12 and their magnetic properties were compared. Oxidation of the magnetic powders easily occurred and weight gain started at 100 °C and suddenly increased at 280 °C. Thermal oxidation of the magnetic powders greatly deteriorated the magnetic properties of the plastic magnets. The surface treatment of the powders was found to be effective for the prevention of the oxidation, especially when treated with PAN, and provided thermally stable plastic magnets.     

Syntheses and characterizations of copolymers of dicyanoquinone methides with α-acetoxystyrenes

Summary 7,7-Dicyanoquinone methides (1a-b) copolymerized spontaneously with substituted -acetoxystyrenes (2a-b) in benzene at 60 °C to give alternating copolymers (poly(1a-b-co-2a-b)) with the molecular weights of 8–60×10⁴ in 42–66% yields. When these copolymers were heated under nitrogen, they eliminated acetic acid quantitatively at around 200 °C to be converted to the copolymers (poly(3a-d)) with olefinic bonds, which were characterized by infrared and nuclear magnetic resonance spectroscopy. Alternating copolymers and the corresponding copolymers with olefinic bonds were amorphous, and capable of being cast from their chloroform solutions into transparent, tough films.     

Solution and solid-state polymerizations of substituted p-quinodimethanes and p-quinone methides

This article describes the polymerization behavior of electron-accepting and electron-donating p-quinonoid monomers such as substituted p-quinodimethanes and p-quinone methides in solutions and solid states. In the solution polymerizations, the electron-accepting substituted p-quinodimethanes and p-quinone methides with same substituents such as cyano, ester, and sulfonyl groups at the exocyclic positions are not homopolymerizable, but copolymerizable with donor monomers like styrene in an alternating fashion. Their spontaneous polymerizations with donor monomers have been explained with the bond-forming initiation mechanism. The substituted p-quinodimethanes with ester groups are a first example to show an amphoteric behavior in alternating copolymerizations. Some electron-accepting substituted p-quinodimethanes and p-quinone methides with different substituents such as cyano, ester, acyl, alkylthio, and/or phenyl groups are homopolymerizable, and an anionic polymerization initiated with a butyllithium initiator proceeded in a living manner. Equilibrium polymerization behavior have been found in their radical homopolymerizations, and on the basis of the thermodynamic parameters determined for their polymerizations, it has been concluded that homopolymerizabilities of the electron-accepting substituted p-quinodimethanes and p-quinone methides are determined exclusively by a steric hindrance effect arising from the substituents at the exocyclic positions. A new concept for the radical alternating copolymerization have been proposed on the basis of the change in modes (random and alternating copolymerizations) for their copolymerizations with styrene and the cross-propagation step analysis by linear free energy relationship. The polymerizations of the electron-donating substituted p-quinodimethanes take place only in the presence of oxygen molecules. In the solid-state polymerizations, some electron-accepting substituted p-quinodimethanes with same ester substituents polymerized topochemically in vacuo, and the strict requirements of topochemical polymerization for substituted p-quinodimethane and p-quinone methide monomers have been determined on the basis of their crystallographic data. Topochemical alternating copolymerization with molecular oxygen in solid state was discovered for the first time.