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排序方式: 共有891条查询结果,搜索用时 15 毫秒
31.
Takahiro Kochi Masahito Shimizu Tomohiko Ohno Atsushi Baba Takafumi Sumi Masaya Kubota Yohei Shirakami Hisashi Tsurumi Takuji Tanaka Hisataka Moriwaki 《International journal of molecular sciences》2013,14(7):14700-14711
Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared to the control WKY rats. Serum levels of angiotensin-II, the active product of the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and hyperleptinemia and exhibited an increase in adipose tissue. The development of AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared to WKY normotensive rats. Furthermore, induction of oxidative stress and exacerbation of inflammation were observed in the colonic mucosa and systemically in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation, which might be associated with activation of the renin-angiotensin system. 相似文献
32.
Na-oyoshi Iwasaki Takanori Miyake Eriko Yagasaki Toshimitsu Suzuki 《Catalysis Today》2006,111(3-4):391-397
Attention has been increasingly paid to the partial oxidation of lower alkanes to synthesis gas, due to its intrinsic energy saving process. We studied the partial oxidation of ethane (POE) on Co loaded on various supports. The POE performance varied as follows: Y2O3, CeO2, ZrO2, La2O3 SiO2, Al2O3, TiO2 > MgO. Comparing Y2O3 and CeO2, the carbon deposition during the POE was negligible on CeO2 and therefore CeO2 was the most preferable support. By changing space velocity and O2 partial pressure, reaction mechanism of POE was studied and it was revealed that two-step mechanism was prevailing; combustion of ethane to H2O and CO2 and subsequent reforming of ethane with H2O and CO2 to synthesis gas. Co/CeO2 catalyst exhibited high and stable catalytic activity for 10 h; high ethane conversion of 18% (maximum ethane conversion 20% at O2/C2H6 = 0.2) with H2 and CO selectivities of 93 and 84%, respectively. 相似文献
33.
We have applied scanning tunnelling microscopy (STM) to the study of two proteins: pseudoazurin and apo-pseudoazurin. Both proteins adsorbed onto a Au (1 1 1) surface are visible to STM individually, forming into layers and multilayers, with currents from about 55 to 600 pA. The images reproduce well the expected dimensions laterally but not in the z direction. The apparent height of the proteins varies with the voltage polarity, being higher at negative sample voltages. The bias also affects their shape. Negative sample voltages of more than 1.5 V orient the proteins present on a gold terrace in parallel rows. The layer of water adsorbed on surfaces in ambient conditions can be related to our results to explain the reduced z dimensions, the asymmetry with the voltage polarity and the alignment of proteins at voltages more negative than -1.5 V. 相似文献
34.
T Taoka S Iwasaki H Uchida A Fukusumi H Nakagawa K Kichikawa K Takayama T Yoshioka M Takewa H Ohishi 《Canadian Metallurgical Quarterly》1998,22(4):514-517
Rifampicin synoviorthesis has been empirically used for the treatment of haemophilic synovitis for some time. This paper reports on the experience of three Latin American centers with this treatment and compares it with radioactive synoviorthesis results. Chemical synoviorthesis with rifampicin is best indicated in younger patients (< 15 years) and small joint (ankles and elbows). 相似文献
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36.
Primary biliary cirrhosis associated with cholangiocarcinoma 总被引:1,自引:0,他引:1
37.
Suppression of mode competition in a LiNdP4 O12 (LNP) laser is reported. The stabilization of the oscillating modes was achieved with a quartz quarter-wave plate placed within an optical resonator without any external modulation. 相似文献
38.
Linear elastic fracture mechanics, which has been applied to fragile substances and successfully used for studying the brittle fracture of metallic materials, was utilized to gain an understanding of the fracture phenomena of sea ice.The present paper reports the first results of investigations into the fracture-toughness value of sea ice, which was analyzed experimentally as a function of strain rate on the basis of the stress-intensity-factor concept.The fracture toughness, KIC, of sea ice, which was measured by an in-situ three-point bending test on notched specimens, shows almost constant value if the strain rate is less then 10?3 s?1 and decreases with increasing strain rate if the strain rate exceeds 10?3 s?1. KIC data show considerably less scatter than existing data such as the compressive, tensile and flexural strengths.It was confirmed in the present study that the linear elastic-fracture-mechanics concept is effective for analyzing the fracture phenomena of sea ice. Moreover, the KIC value was shown to be closely related to sea-ice structures (e.g. the size of crack-like flaws such as brine cells).It is also suggested that the fracture-toughness test might prove to be a standard testing method to obtain the sea-ice strength, since once K1C and crack-like flaw sizes are determined, the less-scattered critical-fracture stress can be calculated. 相似文献
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