Transdermal Absorption of Zidovudine from Ethanol-Isopropyl Myristate Mixed System and Influence of Probenecid on It in Rats

Transdermal absorption of zidovudine (AZT) from an ethanol-isopropyl myristate (IPM) mixed system was examined in rats. For comparison of bioavailability (BA) after topical applications, 0.25 ml of the ethanol/IPM system containing 40% ethanol and 60 mM AZT was applied as a standard formulation. Values of the area under the plasma concentration-time curves of AZT for 8 hr (AUC_0-8), as indices of BA, following application of various formulations were compared with that of the standard formulation. Then the influence of content of the drug and ethanol, and application volume of the system was evaluated. BA was effectively improved only when the total amount of ethanol applied on the skin was increased. On the other hand, simultaneous transdermal application of AZT and probenecid increased the AU_0-8, of AZT without necessitating the increase in ethanol content in the formulation. In addition, coadministered probenecid improved cerebrospinal fluid/plasma concentration ratio of AZT.     

智能测温仪表的研究与实现

文章介绍了一种以8098单片机为核心、以铂铑一铂为测温元件研制的智能化测温仪表，它与传统的接触式温度传感器相比具有价格低、性能高、应用范围广、人机界面好等特点。     

Using a Three-Phase Deterministic Model for the Columnar-to-Equiaxed Transition

In order to overcome the limitations of previous columnar-to-equiaxed (CET) models, which neglect melt convection and the movement of free equiaxed grains, this article presents a three-phase deterministic CET model. With appropriated multiphase volume-averaging approaches, it is possible to account for nucleation and growth of equiaxed grains ahead of a growing columnar front, the influence of melt convection, and grain sedimentation, and the occurrence of a CET in a casting of engineering scale. Special modeling assumptions ensure that both CET mechanisms, namely, “hard” and “soft” blocking, are tackled. It is highly recommended that both mechanisms should be considered, especially in the situation where grain sedimentation and melt convection are present. Although the current model incorporates almost all the physical variables relevant to a CET event, under special condition of a one-dimensional case, the model still reproduces the results of Hunt’s classical CET approach. This article is based on a presentation made in the symposium entitled “Solidification Modeling and Microstructure Formation: In Honor of Prof. John Hunt,” which occurred March 13–15, 2006, during the TMS Spring Meeting in San Antonio, Texas, under the auspices of the TMS Materials Processing and Manufacturing Division, Solidification Committee.     

中小城镇住宅消防设施现状及建设管理探索

通过对西部某小城市的住宅消防设施建设和管理现状的调查 ,反映了占西部绝大部分城市面积的中小城镇的住宅消防设施十分令人担忧的现状 ,分析了造成这一现状的原因 ,提出了解决这一问题的建设管理思路     

房地产开发企业会计核算问题探讨

本文就房地产开发企业会计核算的现状及特点进行了分析,并提出了完善房地产开发企业会计核算规范的对策。     

观赏草在庭园中的设计与应用

观赏草以其灵动的景观特质，草类特有的自然色调，飘逸的质感越来越受到设计师们的青睐，用于焦点、绿蒿、花镜、镶边均有不凡的表现，虽为草类，却有着灌木的功能。     

董公馆：嫁接之美

董公馆是一个6层楼的公寓，依山而建，业主将他交到设计师手里，让他在这基础上活活变出一个精美的“公馆”。     

Analysis of dinosaur samples by nuclear microscopy

Several dinosaur bone and eggshell fossil samples unearthed at different sites in China were analyzed by means of nuclear microscopy. Concentrations and distributions of elements such as Na, Mg, Al, P, S, Ca, Cr, Mn, Fe, Cu, Zn, As, Br, Sr, Y, Ce, Pb and U, etc. were obtained for each sample. The results of quantitative PIXE and RBS analyses show unusually high concentrations of U and Ce in several samples obtained from a period near the K-T boundary (between Cretaceous and Tertiary periods, 65 million years ago), suggesting that some form of environmental pollution could be the cause of dinosaur extinction.     

透水性沥青面层材料设计新法及应用

本文提出了一种根据主骨料空隙率设计透水性面层沥青混合料级配的新方法，根据这一方法设计的透水性沥青面层具有良好的路面使用功能，应用前景广阔。     

专家系统在化工中的应用进展

本文综述了近年来专家系统在化工领域的应用状况，并指出今后的发展趋势。