Motion analysis of a tripod parallel mechanism

A tripod parallel mechanism consists of three links of fixed length and a rigid platform, and these are connected by revolute joints. The platform can achieve sixdegrees-of-freedom (6-DOF) motion by the coordinated movement of the bottom ends of the three links on a horizontal plane. This mechanism has advantages over the more common six extendible parallel manipulators. It has a much larger work space and a simple structure. In this article, we show that the vector analysis for this tripod parallel mechanism and the derivation of the positions of the three bottom ends of the links in an arbitrary attitude of platform can be found by inverse kinematics and the conditions of geometrical constraint. Then, by a numerical simulation, the trajectories of the bottom ends of the three links are shown.     

A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes

We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF. ICSAT is structurally most closely related to the previously cloned ICSBP, a member of the IFN regulatory factor (IRF) family of proteins that binds to interferon consensus sequences (ICSs) found in many promoters of the IFN-regulated genes. Among T-cell lines investigated, ICSAT was abundantly expressed in human T-cell leukemia virus type 1 (HTLV-1)-infected T cells. When the HTLV-1 tax gene was expressed or phorbol myristake acetate-A23187 stimulation was used, ICSAT expression was induced in Jurkat cells which otherwise do not express ICSAT. When the binding of ICSAT to four different ICSs was tested, the relative differences in binding affinities for those ICSs were determined. To study the functional role of ICSAT, we performed cotransfection experiments with the human embryonal carcinoma cell line N-Tera2. ICSAT was demonstrated to possess repressive function over the gene activation induced by IFN stimulation or by IRF-1 cotransfection. Such repressive function is similar to that seen in IRF-2 or ICSBP. However, we have found that ICSAT has a different repressive effect from that of IRF-2 or ICSBP in some IFN-responsive reporter constructs. These results suggest that a novel mechanism of gene regulation by "differential repression" is used by multiple members of repressor proteins with different repressive effects on the IFN-responsive genes.     

Socializing artifacts as a half mirror of the mind

In the near future, our life will normally be surrounded with fairly complicated artifacts, enabled by the autonomous robot and brain–machine interface technologies. In this paper, we argue that what we call the responsibility flaw problem and the inappropriate use problem need to be overcome in order for us to benefit from complicated artifacts. In order to solve these problems, we propose an approach to endowing artifacts with an ability of socially communicating with other agents based on the artifact-as-a-half-mirror metaphor. The idea is to have future artifacts behave according to the hybrid intention composed of the owner’s intention and the social rules. We outline the approach and discuss its feasibility together with preliminary work.

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Two-stage nuclear demagnetization refrigerator

Two-stage nuclear demagnetization has been performed using PrCu₆ and Cu as coolants. The Cu nuclear stage reached temperatures as low as 10 K with a rate of temperature rise of less than a few K/h. The corresponding conduction electron temperature is estimated to be less than 50 K. A nuclear orientation thermometer of Al ⁵⁴Mn has been successfully used to measure temperatures down to 10 K.Supported by the Japan Society for the Promotion of Science.     

Dynamic alternation of primate response properties during trial-and-error knowledge updating

Humans and animals seek appropriate solutions to novel problems through trial-and-error (TE) actions and observation of their outcomes. Once an individual has obtained the knowledge (rule) to solve a problem, knowledge-based (KB) actions may be applied in a stereotypical manner. Solutions can thus be based on TE or KB actions. To characterize this learning process at the behavioral level, we developed a new cognitive task for a laboratory monkey (Macaca fuscata) to perform. In this task, a search array consisting of six elements of different colors was presented, one of which was the behaviorally relevant target. The target color was changed unpredictably with no instruction or signal, requiring the monkey to use a TE search strategy to find the target color. We found that once the monkey identified the relevant color by chance after a color change, correct performance increased in a step-like manner and at the same time, other response properties (reaction time and color-choice tendency) also changed discontinuously. These step-like alternations in behavioral performance may be attributed to the subject’s switching between TE and KB search strategies in the two phases. The present study has therefore provided behavioral evidence for the timing and manner of switching between search strategies during the process of updating knowledge.     

Dimethyl Fumarate Induces Apoptosis via Inhibition of NF-κB and Enhances the Effect of Paclitaxel and Adriamycin in Human TNBC Cells

Triple-negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes. Recently, the activation of NF-κB, which is involved in the growth and survival of malignant tumors, has been demonstrated in TNBC, suggesting that NF-κB may serve as a new therapeutic target. In the present study, we examined whether dimethyl fumarate (DMF), an NF-κB inhibitor, induces apoptosis in TNBC cells and enhances the apoptosis-inducing effect of paclitaxel and adriamycin. Cell survival was analyzed by the trypan blue assay and apoptosis assay. Protein detection was examined by immunoblotting. The activation of NF-κB p65 was correlated with poor prognosis in patients with TNBC. DMF induced apoptosis in MDA-MB-231 and BT-549 cells at concentrations that were non-cytotoxic to the normal mammary cell line MCF-10A. Furthermore, DMF inhibited NF-κB nuclear translocation and Survivin, XIAP, Bcl-xL, and Bcl-2 expression in MDA-MB-231 and BT-549 cells. Moreover, DMF enhanced the apoptosis-inducing effect of paclitaxel and adriamycin in MDA-MB-231 cells. These findings suggest that DMF may be an effective therapeutic agent for the treatment of TNBC, in which NF-κB is constitutively active. DMF may also be useful as an adjuvant therapy to conventional anticancer drugs.     

Local structure,glass transition,structural relaxation,and crystallization of functional oxide glasses investigated by Mössbauer spectroscopy and DTA

This review paper summarizes early Mössbauer and DTA studies of different oxide glasses containing small amounts of iron (III) or tin (IV) as the probe. A lot of valuable information of the atomic level has been obtained about the role of nonbridging oxygen (NBO), network former (NWF), network modifier (NWM), local network structure, glass transition, structural relaxation, crystallization, etc. Introduction of alkali oxide into iron (III)-containing oxide glass causes a marked decrease in glass transition temperature (T_g) amounting to 100 °C and a concordant decrease in quadrupole splitting (Δ) of Fe^III, which reflects decreased distortion of NWF–oxygen polyhedra and formation of NBO. By contrast, introduction of non-alkali oxide into oxide glass causes an increase in T_g amounting to more than 100 °C and a concordant increase in Δ, reflecting increased distortion of NWF–oxygen polyhedra in highly cross-linked network. These experimental results led to a discovery of “T_g-Δ rule”, which was consistent with the “conformer model” proposed for polymers by Matsuoka and Quan. Debye temperatures (θ_D) obtained by low-temperature Mössbauer measurements proved to be useful to determine short- and long-range structures of glass and glass ceramics. Isothermal annealing of vanadate glasses at temperatures higher than T_g or crystallization temperature (T_c) causes a “tunable” decrease in DC-resistivity from the order of MΩ cm to Ω cm. Introduction of metal oxide with a narrow bandgap (E_g) is highly effective to increase the conductivity after the annealing. It was proved that “structural relaxation” of NWF–oxygen polyhedra and resultant decrease in the activation energy (E_a) for conduction are responsible for the improved conductivity. Heat treatment of IR-transmitting aluminate, gallate, and tellurite glasses at temperatures higher than T_g or T_c revealed that crystallization was triggered by the cleavage of NWF–oxygen bonds. These findings will contribute to the development of functional glass and glass ceramics such as smart glass and eco-friendly glass.

     

Route guidance by a car navigation system based on augmented reality

Car navigation systems play a prominent role in road traffic safety and traffic regulation. However, it is necessary to improve the route guidance of car navigation systems so that they accurately and quickly recognize small differences in location. Thus, to increase the ease of understanding and safety of car navigation systems, navigation systems based on augmented reality have been proposed for providing guidance at road intersections. We are currently developing a car navigation system based on augmented reality, called AR‐Navi. We investigated designs for the display of road intersection guidance that can be easily understood even when limited information is available and proposed a “best shot” display method that does not use moving images. In addition, we implemented a prototype system that includes these methods and conducted driving experiments on public roads to evaluate the ease of understanding and safety of AR‐Navi. Using the evaluation results, we confirmed that the ease of understanding and safety is similar in the case of AR‐Navi and CG‐Navi. We also clarified the characteristics of AR‐Navi. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 180(2): 43–54, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22278