Challenges Based on Antiplasmodial and Antiviral Activities of 7-Chloro-4-aminoquinoline Derivatives

We report the structural functionalization of the terminal amino group of N¹-(7-chloroquinolin-4-yl) butane-1,4-diamine, leading to a series of 7-chloro-4-aminoquinoline derivatives, and their evaluation as potent anti-malarial and anti-viral agents. Some compounds exhibited promising anti-malarial effects against the Plasmodium falciparum 3D7 (chloroquine-sensitive) and Dd2 (chloroquine-resistant) strains. In addition, these compounds were assayed in vitro against influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Compound 5 h , bearing an N-mesityl thiourea group, displayed pronounced anti-infectious effects against malaria, IAV, and SARS-CoV-2. These results provide new insights into drug discovery for the prevention or treatment of malaria and virus co-infection.     

Pretreatment with fine bubbles for effective zinc ion precipitation and removal from zinc electroplating wastewater

Heavy metals such as zinc are widely used in plating plants for the processing of material surfaces; therefore, an adequate wastewater treatment is required afterwards to comply with wastewater regulations. However, the presence of chemicals such as degreasing agents in the wastewater generated from the plating process inhibits the formation of hydroxides, thereby making treatment of wastewater and compliance with the stipulated regulations difficult. Herein, the effects of fine bubbles on oil cleaning and wastewater treatment were investigated for developing an alternative cleaning technology to degreasing agents. The concentration of fine bubbles significantly affected the oil cleaning. The fine bubbles demonstrated remarkable cleaning of highly viscous oil, which was difficult to remove using pure water. The high cleaning effect of fine bubbles on oil was achieved because of the hydrophobic interaction of the bubbles. Furthermore, a decrease in cleaning effect was observed for samples with uneven shapes, which was attributed to the difficulty in penetration of fine bubbles in materials with irregularities. Furthermore, fine bubble cleaning exhibited better efficiency for wastewater treatment than degreaser cleaning. Therefore, fine bubble cleaning is speculated to be an excellent cleaning technology with high oil cleaning effectiveness and improved wastewater treatability.