Polyester composites reinforced with noncrimp stitched glass fabrics: Experimental characterization of composites and investigation on the interaction between glass fiber and polyester matrix

The primary purpose of the study was to investigate the anisotropic behavior of different noncrimp stitched fabric reinforced polyester composites. The effects of geometric variables on composite structural integrity and strength are illustrated. Hence, tensile, three‐point bending flexural and short beam shear tests were conducted up to failure on specimens strengthened with different layouts of fibrous plies in noncrimp stitched fabric. The remark, based on the observations while tensile testing, is that the stress–strain curves of polyester based composites were linear in the direction of fibers. However, in the matrix dominated orientations nonlinear relation between the stress and the strain was observed. Another aim of the present work was to investigate the interaction between glass fiber and polyester matrix. The experiments, in conjunction with scanning electron photomicrographs of fractured surfaces of composites, were interpreted in an attempt to explain the interaction between glass fiber and polyester and were interpreted in an attempt to explain the instability of polyester resin–glass fiber interfaces. It was concluded that the polymer was either deposited between adjacent fibers or as widely separated islands on the fiber surface. Infrared spectra of the cured polyester and its glass fiber composite were obtained by Fourier transform infrared spectroscopy. POLYM. COMPOS., 2008. © 2007 Society of Plastics Engineers     

SPH with the multiple boundary tangent method

In this article, we present an improved solid boundary treatment formulation for the smoothed particle hydrodynamics (SPH) method. Benchmark simulations using previously reported boundary treatments can suffer from particle penetration and may produce results that numerically blow up near solid boundaries. As well, current SPH boundary approaches do not properly treat curved boundaries in complicated flow domains. These drawbacks have been remedied in a new boundary treatment method presented in this article, called the multiple boundary tangent (MBT) approach. In this article we present two important benchmark problems to validate the developed algorithm and show that the multiple boundary tangent treatment produces results that agree with known numerical and experimental solutions. The two benchmark problems chosen are the lid‐driven cavity problem, and flow over a cylinder. The SPH solutions using the MBT approach and the results from literature are in very good agreement. These solutions involved solid boundaries, but the approach presented herein should be extendable to time‐evolving, free‐surface boundaries. Copyright © 2008 John Wiley & Sons, Ltd.     

A Novel High Content Angiogenesis Assay Reveals That Lacidipine,L-Type Calcium Channel Blocker,Induces In Vitro Vascular Lumen Expansion

Angiogenesis is a critical cellular process toward establishing a functional circulatory system capable of delivering oxygen and nutrients to the tissue in demand. In vitro angiogenesis assays represent an important tool for elucidating the biology of blood vessel formation and for drug discovery applications. Herein, we developed a novel, high content 2D angiogenesis assay that captures endothelial morphogenesis’s cellular processes, including lumen formation. In this assay, endothelial cells form luminized vascular-like structures in 48 h. The assay was validated for its specificity and performance. Using the optimized assay, we conducted a phenotypic screen of a library containing 150 FDA-approved cardiovascular drugs to identify modulators of lumen formation. The screening resulted in several L-type calcium channel blockers being able to expand the lumen space compared to controls. Among these blockers, Lacidipine was selected for follow-up studies. We found that the endothelial cells treated with Lacidipine showed enhanced activity of caspase-3 in the luminal space. Pharmacological inhibition of caspase activity abolished the Lacidipine-enhancing effect on lumen formation, suggesting the involvement of apoptosis. Using a Ca²⁺ biosensor, we found that Lacipidine reduces the intracellular Ca²⁺ oscillations amplitude in the endothelial cells at the early stage, whereas Lacidipine blocks these Ca²⁺ oscillations completely at the late stage. The inhibition of MLCK exhibits a phenotype of lumen expansion similar to that of Lacidipine. In conclusion, this study describes a novel high-throughput phenotypic assay to study angiogenesis. Our findings suggest that calcium signalling plays an essential role during lumen morphogenesis. L-type Ca²⁺ channel blockers could be used for more efficient angiogenesis-mediated therapies.     

NEURAL MODELS FOR THE BROADSIDE-COUPLED V-SHAPED MICROSHIELD COPLANAR WAVEGUIDES

This article presents a new approach based on multilayered perceptron neural networks (MLPNNs) to calculate the odd-and even-mode characteristic impedances and effective permittivities of the broadside-coupled V-shaped microshield coplanar waveguides (BC-VSMCPWs). Six learning algorithms, bayesian regulation (BR), Levenberg-Marquardt (LM), quasi-Newton (QN), scaled conjugate gradient (SCG), resilient propagation (RP), and conjugate gradient of Fletcher-Powell (CGF), are used to train the MLPNNs. The neural results are in very good agreement with the results reported elsewhere. When the performances of neural models are compared with each other, the best and worst results are obtained from the MLPNNs trained by the BR and CGF algorithms, respectively.     

Neonatal purpura fulminans due to homozygous protein C deficiency

All aspects of surgical decision making,--why, what, when, where, how and to whom--are being subjected to an increasingly accurate analysis. The principles of this analysis should form an essential part of the theoretical curriculum of all surgeons, young and old. Only by these means can the production of health benefits be maximized and the definitive goal of all surgical care be attained: the maximization of produced health benefits. This article provides a short outline of decision analysis in surgery.