Divergent prolactin and pituitary-adrenal activity in rats selectively bred for different dopamine responsiveness

The present study explores the significance of brain dopamine phenotype for individual variation in the neuroendocrine stress response of the rat. For this purpose, we used two Wistar rat lines previously selected for high or low responsiveness of the dopamine system to apomorphine using the gnawing response as the selection criterion. Systemic administration of the drug evoked in apomorphine-susceptible (apo-sus) rats a vigorous gnawing response, whereas apomorphine-unsusceptible (apo-unsus) rats did not gnaw under these conditions. These two rat lines represent individuals displaying extreme differences in gnawing behavior that otherwise coexist in a normal Wistar population. In this study basal and stress-induced hypothalamic-pituitary-adrenal activity and PRL release were measured in chronically cannulated, freely moving rats that endured a conditioned emotional response. Tyrosine hydroxylase messenger RNA (mRNA), corticosteroid receptor mRNA, and in vivo retention of [3H]corticosterone were measured in rat brain sections using in situ hybridization and in vivo autoradiography. The result show that 1) apo-sus rats had a markedly reduced PRL response to stress compared to apo-unsus animals, whereas basal levels were not significantly different. A12 dopaminergic neurons in the arcuate nucleus expressed significantly higher levels of tyrosine hydroxylase mRNA in apo-sus rats, suggesting that the reduced stress-induced PRL release could be due to an increased inhibitory control by dopaminergic neurons; 2) in apo-sus rats, stress resulted in a sustained elevation of ACTH and free corticosterone levels, whereas the total corticosterone levels were not different between the two rat lines; 3) under basal morning conditions, apo-sus rats had significantly higher plasma ACTH, but, in contrast, lower free corticosterone than apo-unsus rats; total plasma corticosterone levels were not different; 4) the basal evening ACTH level was elevated in apo-sus rats; after removal of the adrenals in the morning, this increased ACTH level in apo-sus rats persisted into the afternoon 6 h postadrenalectomy; and 5) hippocampal mineralocorticoid (MR), but not glucocorticoid (GR), receptor capacity for the ligand comparable between the groups; the MR of apo-sus rats displayed an increased retention of [3H]corticosterone in all hippocampal cell fields measured 24 h adrenalectomy; MR and GR mRNA in hippocampus as well as GR mRNA in the paraventricular nucleus were not significantly different in the two rat lines. In conclusion, the data suggest a common genetic background for individual variation in stress responsiveness and dopamine phenotype. High dopamine reactivity is linked to a reduced PRL and an increased ACTH response after stress. These high dopamine responders display a hyporesponsive adrenal cortex and corticosteroid feedback resistance associated with altered brain corticosteroid receptor properties.     

移动式小型X线机综合防护装置

本文介绍一种移动式小型 X 线机综合防护装置。该装置把便于运输的部件、防护隔屏及暗室融为一体,为 X 线工作者、被检者和被检者提供了较好的防护。本文介绍一种移动式小型 X 线机综合防护装置。现将其基本构造和防护效果简介如下:     

Miscibility of polyamide-6 and polystyrene functionalized with sulfonic acid groups

Polyamide-6 (PA-6) and sulfonated polystyrene (SPS) interact strongly in solution. Thus, solution blends of PA-6 and SPS (sulfonation levels from 0 to 12.3 mol%) in m-cresol form clear, hazy, or gelled solutions–depending on the ratio of amide (A) to sulfonic acid (S) groups (A/S). NMR studies show that the S groups interact with the nitrogen of the amides, most probably through the transfer of the sulfonic acid protons. During melt blending, the addition of SPS to the PA-6 leads to a torque rise because of strong interactions. The glass transition temperatures of the components in the melt blended samples shift towards each other as the sulfonation level of the SPS increases, indicating enhanced miscibility. The analysis of the extracted PA-6 from thee blends, however, shows that it is degraded at processing temperatures (250°C), owing to some residual water and the catalytic activity of the sulfonic acid groups. The extent of the PA-6 degradation is inversely related to the A/S ratio. Each sulfonic acid group causes between one and two chain scissions of the PA-6. In blends with high A/S ratios, the degradation of the PA-6 is minimal; yet considerable dispersion of the SPS can be achieved, as evidenced by scanning electron micrographs of the fracture surfaces.     

Blends of polyurethane carboxylates with styrene vinylpyridinium copolymers

This is a continuation of an ongoing investigation of miscibility enhancement via ionic interactions in urethane-styrene blends. The present study deals with a polyurethane which contains in the hard segments pendant carboxylate groups neutralized by ammonium ions while the polystyrene contains pendant vinyl pyridinium methyl iodide groups. Miscibility of the styrene is seen with the hard segments of the urethane because of ion pair/ion pair interactions. Methanol extraction raises the T_g because it eliminates low molecular weight components, without removing the microions.     

An efficient phishing webpage detector

Phishing attack is growing significantly each year and is considered as one of the most dangerous threats in the Internet which may cause people to lose confidence in e-commerce. In this paper, we present a heuristic method to determine whether a webpage is a legitimate or a phishing page. This scheme could detect new phishing pages which black list based anti-phishing tools could not. We first convert a web page into 12 features which are well selected based on the existing normal and fishing pages. A training set of web pages including normal and fishing pages are then input for a support vector machine to do training. A testing set is finally fed into the trained model to do the testing. Compared to the existing methods, the experimental results show that the proposed phishing detector can achieve the high accuracy rate with relatively low false positive and low false negative rates.     

The influence of micronised particulates on the aerosolisation properties of pressurised metered dose inhalers

A fundamental study of the interactions between binary particulate formulations in HFA-based pressurised metered dose inhaler (pMDI) systems was undertaken. Differences in the surface energetics of lactose, mannitol and sibenadet hydrochloride were observed, which could be related to the degree of particle adhesion/cohesion, the sedimentation rate and the aerosolisation performance of formulations containing different mixtures of these components. In general, lactose was shown to be the most cohesive material and readily formed coarse aggregates with sibenadet hydrochloride which sedimented rapidly. This had the greatest effect on aerosolisation performance at high-lactose concentrations (and low-sibenadet hydrochloride concentrations), where heavily agglomerated particles were observed in collected samples of the emitted aerosol. A model, relating the adhesive and cohesive forces between the components in these systems has been proposed, which satisfactorily describes these phenomena. Furthermore, although the more energetic systems were shown to result in significantly decreased aerosol performance, the through-life performance was enhanced.     

Right ventricular strain and volume analyses through deep learning-based fully automatic segmentation based on radial long-axis reconstruction of short-axis cine magnetic resonance images

Magnetic Resonance Materials in Physics, Biology and Medicine - We propose a deep learning-based fully automatic right ventricle (RV) segmentation technique that targets radially reconstructed...     

A Data Classification Method for Inconsistency and Incompleteness Detection in Access Control Policy Sets

Access control policies may contain anomalies such as incompleteness and inconsistency, which can result in security vulnerabilities. Detecting such anomalies in large sets of complex policies automatically is a difficult and challenging problem. In this paper, we propose a novel method for detecting inconsistency and incompleteness in access control policies with the help of data classification tools well known in data mining. Our proposed method consists of three phases: firstly, we perform parsing on the policy data set; this includes ordering of attributes and normalization of Boolean expressions. Secondly, we generate decision trees with the help of our proposed algorithm, which is a modification of the well-known C4.5 algorithm. Thirdly, we execute our proposed anomaly detection algorithm on the resulting decision trees. The results of the anomaly detection algorithm are presented to the policy administrator who will take remediation measures. In contrast to other known policy validation methods, our method provides means for handling incompleteness, continuous values and complex Boolean expressions. In order to demonstrate the efficiency of our method in discovering inconsistencies, incompleteness and redundancies in access control policies, we also provide a proof-of-concept implementation.     

Synthesis of short-channeled amino-functionalized SBA-15 and its beneficial applications in base-catalyzed reactions

Amino-functionalized-SBA-15 catalysts with nanostructured hexagonal platelet morphologies were synthesized directly by using microwave synthesis from the hydrolysis and co-condensation of aminopropyltriethoxysilane (APTES) and sodium metasilicate under a strong acidic condition with the Pluronic P123 triblock copolymer as a structure-directing agent. The amino-functionalized-SBA-15 catalysts were proven by SEM and TEM techniques to have very short channels in the range of 200–300 nm perpendicular to the hexagonal platelet morphologies. These short-channeled catalysts were proven to be effective heterogeneous catalysts in liquid-phase reactions such as Knoevenagel and Claisen-Schmidt condensations as well as in Henry reaction. They exhibited greatly improved catalytic activities over the typical fibrous type SBA-15 catalyst having long channels. Obviously, the easy diffusion and rapid mass transfer of substrate into the short channel mesopores played important roles in the significant improvement in the catalytic activities.     

The influence of user interaction and participation in social media on the consumption intention of niche products

Social media may be particularly adept at promoting niche products because of the tendency of consumers to participate in generating reviews and discussing such products, thereby raising interest in them. In this study, we investigate how patterns of user interaction in discussing a niche cultural product may influence participation levels, which in turn enhance consumption intentions. We show that higher levels of participation can indeed enhance consumption intention. Furthermore, interaction patterns with high inclusiveness and betweenness centralization may enhance participation levels, whereas out-degree centralization and core-periphery have a detrimental influence. Implications for research and practice are discussed.