Synthesis,characterization, and thermal degradation kinetics of the copolymer poly(4‐methoxybenzyl methacrylate‐co‐isobornyl methacrylate)

A copolymer of 4‐methoxybenzyl methacrylate and isobornyl methacrylate was synthesized by atom transfer radical polymerization. The structure of poly(4‐methoxybenzyl methacrylate‐co‐isobornyl methacrylate) was confirmed by means of Fourier transform infrared, ¹H‐NMR, and ¹³C‐NMR techniques. The molecular weight distribution values of the copolymer were determined with gel permeation chromatography. The number‐average molecular weight and polydispersity index values of poly(4‐methoxybenzyl methacrylate‐co‐isobornyl methacrylate) were found to be 12,500 and 1.5, respectively. The kinetics of the thermal degradation of the copolymer was investigated with thermogravimetric analysis at different heating rates. The activation energy values obtained with the Kissinger, Flynn–Wall–Ozawa, and Tang methods were determined to be 166.38, 167.54, and 167.47 kJ/mol, respectively. Different integral and differential methods were used, and the results were compared with these values. Doyle approximation was also used for comparing the experimental results to master plots. An analysis of the experimental results suggested that the reaction mechanism was an R₁ deceleration type in the conversion range studied. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

A study on the optical properties of three‐armed polystyrene and poly(styrene‐b‐isobutyl methacrylate)

Atom transfer radical polymerization (ATRP) of three‐armed polystyrene[PS] and poly(styrene‐b‐isobutyl methacrylate)[PS‐b‐PiBμMA] were accomplished using an initiator with tri‐active C‐Br end group function and cuprous (I) bromide/2,2′‐bipyridyne catalytic system. The characterization obtained by FT‐IR, ¹H‐NMR, and GPC techniques. The average molecular weight and polydispersity of PS and PS‐b‐PiBμMA were determined as 19,800, 29,300 and as 1.37 and 1.15, respectively, which indicates that the constant concentration of growing chains are present throughout the polymerization. The refractive index and extinction coefficient of the samples were determined in the visible range as a function of wavelength. The refractive index dispersion curves of the thin films were fitted by the Cauchy‐Sellmeier model. The width of localized states (E_u) values changed inversely with optical band gaps (E_g) of the films. While the calculated E_u values of films for initiator, PS and PS‐b‐PiBμMA were determined as 2.72, 2.98, and 2.94 eV, the E_g values were determined as 3.43; 3.11, and 3.16 eV, respectively. The dispersion parameters of thin films were determined. These parameters changed in the investigated wavelength ranges. POLYM. ENG. SCI., 2009. © 2009 Society of Plastics Engineers     

Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential (TRP) channels, purinergic receptor (P2Y), and mitogen-activated protein kinase (MAPK) signaling play a crucial role in the pathogenesis of neuropathic pain. Withametelin (WMT), a potential Phytosteroid isolated from datura innoxa, exhibits remarkable neuroprotective properties. The present investigation was designed to explore the effect of withametelin on VCR-induced neuropathic pain and its underlying molecular mechanism. Initially, the neuroprotective potential of WMT was confirmed against hydrogen peroxide (H₂O₂)-induced PC12 cells. To develop potential candidates for neuropathic pain treatment, a VCR-induced neuropathic pain model was established. Vincristine (75 μg/kg) was administered intraperitoneally (i.p.) for 10 consecutive days (day 1–10) for the induction of neuropathic pain. Gabapentin (GBP) (60 mg/kg, i.p.) and withametelin (0.1 and 1 mg/kg i.p.) treatments were given after the completion of VCR injection on the 11th day up to 21 days. The results revealed that WMT significantly reduced VCR-induced pain hypersensitivity, including mechanical allodynia, cold allodynia, and thermal hyperalgesia. It reversed the VCR-induced histopathological changes in the brain, spinal cord, and sciatic nerve. It inhibited VCR-induced changes in the biochemical composition of the myelin sheath of the sciatic nerve. It markedly downregulated the expression levels of TRPV1 (transient receptor potential vanilloid 1); TRPM8 (Transient receptor potential melastatin 8); and P2Y nociceptors and MAPKs signaling, including ERK (Extracellular Signal-Regulated Kinase), JNK (c-Jun N-terminal kinase), and p-38 in the spinal cord. It suppressed apoptosis by regulating Bax (Bcl2-associated X-protein), Bcl-2 (B-cell-lymphoma-2), and Caspase-3 expression. It considerably attenuated inflammatory cytokines, oxidative stress, and genotoxicity. This study suggests that WMT treatment suppressed vincristine-induced neuropathic pain by targeting the TRPV1/TRPM8/P2Y nociceptors and MAPK signaling.     

Melatonin for Neonatal Encephalopathy: From Bench to Bedside

Neonatal encephalopathy is a leading cause of morbidity and mortality worldwide. Although therapeutic hypothermia (HT) is now standard practice in most neonatal intensive care units in high resource settings, some infants still develop long-term adverse neurological sequelae. In low resource settings, HT may not be safe or efficacious. Therefore, additional neuroprotective interventions are urgently needed. Melatonin’s diverse neuroprotective properties include antioxidant, anti-inflammatory, and anti-apoptotic effects. Its strong safety profile and compelling preclinical data suggests that melatonin is a promising agent to improve the outcomes of infants with NE. Over the past decade, the safety and efficacy of melatonin to augment HT has been studied in the neonatal piglet model of perinatal asphyxia. From this model, we have observed that the neuroprotective effects of melatonin are time-critical and dose dependent. Therapeutic melatonin levels are likely to be 15–30 mg/L and for optimal effect, these need to be achieved within the first 2–3 h after birth. This review summarises the neuroprotective properties of melatonin, the key findings from the piglet and other animal studies to date, and the challenges we face to translate melatonin from bench to bedside.     

Denoising of arterial spin labeling data: wavelet-domain filtering compared with Gaussian smoothing

Purpose  

To investigate a wavelet-based filtering scheme for denoising of arterial spin labeling (ASL) data, potentially enabling reduction of the required number of averages and the acquisition time.     

Technical note an evaluation of water corrosivity of the river tigris at Baghdad

A series of experiments was carried out on different samples of tap water abstracted from the Baghdad water supply network in order to observe the effect of water on supply pipes, either scale forming or corrosive. This experimental investigation on the corrosive effect of the city of Baghdad tap water showed that the water can be classified as corrosive according to the Ryznar index, while the Langelier index showed that the water has the ability to form scale on the pipes. However, personal field observation indicated that the water is corrosive to the pipes and to the network appurtenance. Other findings are reported herein.     

FPGA Based Implementation and Comparison of Beamformers for CDMA2000

For the integration of smart antennas into third generation code division multiple access (CDMA) base stations, it still remains as a challenging task to implement smart antenna algorithms on programmable processors. In this paper, we study implementations of some CDMA compatible beamforming algorithms, namely least mean square (LMS), constant modulus (CM), and space code correlator (SCC) algorithms, using Xilinx??s Virtex family FPGAs. This study exhibits feasibility of implementing even simple, practical, and computationally small algorithms based on today??s most powerful FPGA technologies. 16 and 32 bits floating point implementations of the algorithms are investigated using both Virtex II and Virtex IV FPGAs. CDMA2000 reverse link baseband signal format is used in the signal modeling. Randomly changing fading and Direction-of-arrivals (DOAs) of multipaths are considered as a channel condition. The implementation results in terms of beamforming accuracy, FPGA resource utilization, weight vector computation time, and DOA estimation error are presented. Beamformer weight vectors using LMS and CM can be computed within less than 20 ??s on Virtex II FPGA and 10 ??s on Virtex IV FPGA, and using SCC it can be achieved within less than 22 ??s on Virtex IV FPGA. These results show that FPGAs provide approximately 500 times faster speed in implementations than our previous work with DSPs.     

Construction safety issues in Gaza Strip

Safety is considered a critical problem in developed and developing countries. The author examines the causes of accidents on building sites and the safety procedures used by local contractors in Gaza Strip. A wide range of recommendations are necessary if hazards are to be eliminated and accidents reduced. Recommendations include a suitable training programme, supervisory methods for product quality and working conditions on site, improved working conditions, a safety regulatory framework including a safety institution, standards, and penalties. La securite est consideree comme un probleme critique dans les pays industrialises et dans les pays en developpement. L'auteur examine les causes des accidents sur les chantiers de construction dans la Bande de Gaza ainsi que les procedures de securite appliquees par les entreprises locales. Pour eliminer les dangers et reduire le nombre d'accidents, il conviendrait de formuler de nombreuses recommandations portant, notamment, sur un programme de formation approprie, des methodes de suivi de la "qualito produits" et de supervision des conditions de travail sur les chantiers. Il faudrait d'ailleurs ameliorer ces conditions et definir un cadre de reglementation en matiere de securite comprenant, entre autres, la creation d'un institut de la securite, l'elaboration de normes et la mise en place d'un mecanisme de penalites.     

Sliding mode control of a bioreactor

In this paper, sliding mode control (SMC) of a bioreactor is considered and is compared with PID control. The magnitude of the error in SMC is found to be lower than that in PID control. Moreover, the magnitudes of cells and nutrients were very close to the selected reference values in SMC, whereas they were quite different in PID control. Overall, SMC was more robust against disturbances and had better performance than PID control.